Anxiolytic-like effect of the leaves of Pseudospondias microcarpa (A. Rich.) Engl. in mice
-
Donatus Wewura Adongo
,
Priscilla Kolibea Mante
,
Elvis Ofori Ameyaw
Abstract
Background:
Pseudospondias microcarpa is a plant used for managing various diseases including CNS disorders. Previous studies showed sedative and anticonvulsant effects, suggesting possible anxiolytic activity. This study therefore assessed the anxiolytic effects of P. microcarpa hydroethanolic leaf extract (PME) in mice.
Methods:
In the present study, anxiolytic-like effect of the extract in behavioural paradigms of anxiety – the elevated plus maze (EPM), light/dark box (LDB), social interaction test and stress-induced hyperthermia (SIH) – was evaluated.
Results:
Mice treated with PME (30–300 mg kg−1, p.o.) exhibited anxiolytic-like activity similar to diazepam in all the anxiety models used. The extract increased open arm activity (p<0.05) in the EPM as well as increasing the time spent in the lit area in relation to the time spent in the dark area of the LDB. Sociability and preference for social novelty significantly (p<0.05–0.001) increased in mice treated with PME. In the SIH paradigm in mice, both PME and the benzodiazepine receptor agonist, diazepam, significantly (p<0.05) reduced the stress-induced increase in rectal temperature. The extract did not impair motor coordination and balance in the beam walk test.
Conclusions:
Results of the present study indicate that PME possesses anxiolytic-like effects in mice.
Acknowledgments:
We are grateful to Messrs Thomas Ansah, Gordon Darku, Prosper Akortia, Edmond Dery and Prince Okyere of the Department of Pharmacology for their technical assistance.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organisation(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2016 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Review
- Non-diabetic clinical applications of insulin
- Mini Review
- Monophasic action potential recordings: which is the recording electrode?
- Behavior and Neuroprotection
- Histamine H3 receptor antagonists display antischizophrenic activities in rats treated with MK-801
- Nephroprotective effect of β-sitosterol on N-diethylnitrosamine initiated and ferric nitrilotriacetate promoted acute nephrotoxicity in Wistar rats
- Reproduction
- Implication of caffeine consumption and recovery on the reproductive functions of adult male Wistar rats
- Cardiovascular Function
- Cosmic ray (neutron) activity and air pollution nanoparticles – cardiovascular disease risk factors – separate or together?
- Oxidative Stress
- Nephrotoxicity of sodium valproate and protective role of L-cysteine in rats at biochemical and histological levels
- Effect of protocatechuic acid on lipid profile and DNA damage in D-galactosamine-induced hepatotoxic rats
- Oral administration of green plant-derived chemicals and antioxidants alleviates stress-induced cellular oxidative challenge
- Phytotherapy
- Scientific evidence of plant with a rapid-onset and sustained antidepressant effect in a chronic model of depression: Mallotus oppositifolius
- Anxiolytic-like effect of the leaves of Pseudospondias microcarpa (A. Rich.) Engl. in mice
- Comparative phytochemical profiling of Clerodendrum infortunatum with some selected medicinal plants predominant in the Sub-Himalayan region of West Bengal
Articles in the same Issue
- Frontmatter
- Review
- Non-diabetic clinical applications of insulin
- Mini Review
- Monophasic action potential recordings: which is the recording electrode?
- Behavior and Neuroprotection
- Histamine H3 receptor antagonists display antischizophrenic activities in rats treated with MK-801
- Nephroprotective effect of β-sitosterol on N-diethylnitrosamine initiated and ferric nitrilotriacetate promoted acute nephrotoxicity in Wistar rats
- Reproduction
- Implication of caffeine consumption and recovery on the reproductive functions of adult male Wistar rats
- Cardiovascular Function
- Cosmic ray (neutron) activity and air pollution nanoparticles – cardiovascular disease risk factors – separate or together?
- Oxidative Stress
- Nephrotoxicity of sodium valproate and protective role of L-cysteine in rats at biochemical and histological levels
- Effect of protocatechuic acid on lipid profile and DNA damage in D-galactosamine-induced hepatotoxic rats
- Oral administration of green plant-derived chemicals and antioxidants alleviates stress-induced cellular oxidative challenge
- Phytotherapy
- Scientific evidence of plant with a rapid-onset and sustained antidepressant effect in a chronic model of depression: Mallotus oppositifolius
- Anxiolytic-like effect of the leaves of Pseudospondias microcarpa (A. Rich.) Engl. in mice
- Comparative phytochemical profiling of Clerodendrum infortunatum with some selected medicinal plants predominant in the Sub-Himalayan region of West Bengal
