Scientific evidence of plant with a rapid-onset and sustained antidepressant effect in a chronic model of depression: Mallotus oppositifolius
-
Kennedy K.E. Kukuia
,
Elvis O. Ameyaw
Abstract
Background:
One of the major drawbacks of current depression pharmacotherapy is the delay in symptom improvement, aside from the untoward side effects and lack of efficacy against refractory depression. This work therefore investigated a possible rapid-onset and sustained antidepressant effect of Mallotus oppositifolius.
Methods:
Onset of the antidepressant effect of hydroalcoholic extract from the leaves of M. oppositifolius was investigated using the open space swim test, a chronic depression model. The possible effects of the extract on cognitive dysfunction measured in the Morris water maze and weight gain were also investigated.
Results:
M. oppositifolius extract, after the first day of treatment, reversed the state of immobility in mice. This effect was sustained even after drug treatment was halted and the antidepressant effect verified in the tail suspension test. The extract also increased the total distance travelled by the mice and reversed the cognitive impairment induced by the depressed state but had no effect on weight variation.
Conclusions:
M. oppositifolius exhibits a rapid-onset and sustained antidepressant effect in mice.
Acknowledgments:
The authors would like to express their profound gratitude to Thomas Ansah and all technicians of the Department of Pharmacology, Kwame Nkrumah University of Science and Technology for their assistance.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: No funding organization played a role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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- Oxidative Stress
- Nephrotoxicity of sodium valproate and protective role of L-cysteine in rats at biochemical and histological levels
- Effect of protocatechuic acid on lipid profile and DNA damage in D-galactosamine-induced hepatotoxic rats
- Oral administration of green plant-derived chemicals and antioxidants alleviates stress-induced cellular oxidative challenge
- Phytotherapy
- Scientific evidence of plant with a rapid-onset and sustained antidepressant effect in a chronic model of depression: Mallotus oppositifolius
- Anxiolytic-like effect of the leaves of Pseudospondias microcarpa (A. Rich.) Engl. in mice
- Comparative phytochemical profiling of Clerodendrum infortunatum with some selected medicinal plants predominant in the Sub-Himalayan region of West Bengal
Articles in the same Issue
- Frontmatter
- Review
- Non-diabetic clinical applications of insulin
- Mini Review
- Monophasic action potential recordings: which is the recording electrode?
- Behavior and Neuroprotection
- Histamine H3 receptor antagonists display antischizophrenic activities in rats treated with MK-801
- Nephroprotective effect of β-sitosterol on N-diethylnitrosamine initiated and ferric nitrilotriacetate promoted acute nephrotoxicity in Wistar rats
- Reproduction
- Implication of caffeine consumption and recovery on the reproductive functions of adult male Wistar rats
- Cardiovascular Function
- Cosmic ray (neutron) activity and air pollution nanoparticles – cardiovascular disease risk factors – separate or together?
- Oxidative Stress
- Nephrotoxicity of sodium valproate and protective role of L-cysteine in rats at biochemical and histological levels
- Effect of protocatechuic acid on lipid profile and DNA damage in D-galactosamine-induced hepatotoxic rats
- Oral administration of green plant-derived chemicals and antioxidants alleviates stress-induced cellular oxidative challenge
- Phytotherapy
- Scientific evidence of plant with a rapid-onset and sustained antidepressant effect in a chronic model of depression: Mallotus oppositifolius
- Anxiolytic-like effect of the leaves of Pseudospondias microcarpa (A. Rich.) Engl. in mice
- Comparative phytochemical profiling of Clerodendrum infortunatum with some selected medicinal plants predominant in the Sub-Himalayan region of West Bengal
