Nephrotoxicity of sodium valproate and protective role of L-cysteine in rats at biochemical and histological levels
-
Nahla S. El-Shenawy
and
Reham Z. Hamza
Abstract
Background:
This study investigated whether the combination of sodium valproate (SV) with L-cysteine (LC) can decrease the SV toxicity of kidneys. SV caused alternation in oxidative/antioxidant balance.
Methods:
Biochemical estimations included the determination of oxidative stress markers like thiobarbituric acid-reactive substances in kidney tissue, and enzymatic antioxidant activities such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase as well as total antioxidant capacity were evaluated in renal tissues. Creatinine and uric acid levels in the serum were also determined to assess kidney function. Pathological examination of the kidney was also performed.
Results:
Increasing the levels of lipid peroxidation and decreasing the enzymatic activity (SOD, CAT, and GPx) as well as total antioxidant capacity of rats was shown with different doses of SV. Impairment in renal function tests suggests a decreased glomerular filtration rate, as serum creatinine was elevated. Histopathological changes of kidney tissue treated with SV reveal the proximal and the distal convoluted tubules that show hydropic changes (small white vacuoles within the cytoplasm and the glomeruli show hypercellularity).
Conclusions:
The concurrent administration of LC with SV significantly had beneficial effects on the kidney and all the above parameters have been improved.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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©2016 Walter de Gruyter GmbH, Berlin/Boston
Articles in the same Issue
- Frontmatter
- Review
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- Monophasic action potential recordings: which is the recording electrode?
- Behavior and Neuroprotection
- Histamine H3 receptor antagonists display antischizophrenic activities in rats treated with MK-801
- Nephroprotective effect of β-sitosterol on N-diethylnitrosamine initiated and ferric nitrilotriacetate promoted acute nephrotoxicity in Wistar rats
- Reproduction
- Implication of caffeine consumption and recovery on the reproductive functions of adult male Wistar rats
- Cardiovascular Function
- Cosmic ray (neutron) activity and air pollution nanoparticles – cardiovascular disease risk factors – separate or together?
- Oxidative Stress
- Nephrotoxicity of sodium valproate and protective role of L-cysteine in rats at biochemical and histological levels
- Effect of protocatechuic acid on lipid profile and DNA damage in D-galactosamine-induced hepatotoxic rats
- Oral administration of green plant-derived chemicals and antioxidants alleviates stress-induced cellular oxidative challenge
- Phytotherapy
- Scientific evidence of plant with a rapid-onset and sustained antidepressant effect in a chronic model of depression: Mallotus oppositifolius
- Anxiolytic-like effect of the leaves of Pseudospondias microcarpa (A. Rich.) Engl. in mice
- Comparative phytochemical profiling of Clerodendrum infortunatum with some selected medicinal plants predominant in the Sub-Himalayan region of West Bengal
Articles in the same Issue
- Frontmatter
- Review
- Non-diabetic clinical applications of insulin
- Mini Review
- Monophasic action potential recordings: which is the recording electrode?
- Behavior and Neuroprotection
- Histamine H3 receptor antagonists display antischizophrenic activities in rats treated with MK-801
- Nephroprotective effect of β-sitosterol on N-diethylnitrosamine initiated and ferric nitrilotriacetate promoted acute nephrotoxicity in Wistar rats
- Reproduction
- Implication of caffeine consumption and recovery on the reproductive functions of adult male Wistar rats
- Cardiovascular Function
- Cosmic ray (neutron) activity and air pollution nanoparticles – cardiovascular disease risk factors – separate or together?
- Oxidative Stress
- Nephrotoxicity of sodium valproate and protective role of L-cysteine in rats at biochemical and histological levels
- Effect of protocatechuic acid on lipid profile and DNA damage in D-galactosamine-induced hepatotoxic rats
- Oral administration of green plant-derived chemicals and antioxidants alleviates stress-induced cellular oxidative challenge
- Phytotherapy
- Scientific evidence of plant with a rapid-onset and sustained antidepressant effect in a chronic model of depression: Mallotus oppositifolius
- Anxiolytic-like effect of the leaves of Pseudospondias microcarpa (A. Rich.) Engl. in mice
- Comparative phytochemical profiling of Clerodendrum infortunatum with some selected medicinal plants predominant in the Sub-Himalayan region of West Bengal
