A hydro-ethanolic extract of Synedrella nodiflora (L.) Gaertn ameliorates hyperalgesia and allodynia in vincristine-induced neuropathic pain in rats
-
Patrick Amoateng
,
Samuel Adjei
Abstract
Background: The hydro-ethanolic extract of Synedrella nodiflora (L.) Gaertn whole plant has demonstrated analgesic effects in acute pain models. The extract has also demonstrated anticonvulsant effects in murine models of experimental epilepsy. The present study illustrates an evaluation of the hydro-ethanolic extract of the plant for possible analgesic properties in hyperalgesia and allodynia associated with vincristine-induced neuropathy in rats.
Methods: Neuropathic pain was induced in Sprague-Dawley rats by injecting 100 μg/kg of vincristine sulphate on alternative days for 6 days (days 0, 2, 4, 8, 10 and 12). Vincristine-induced cold allodynia, mechanical hyperalgesia and thermal hyperalgesia were measured pre-vincristine administration and on days 15, 17 and 19 post-vincristine administration. The rats were then treated with S. nodiflora extract (SNE) (100, 300 and 1000 mg/kg), pregabalin (10, 30 and 100 mg/kg) and distilled water as vehicle daily for 5 days and pain thresholds were measured on alternate days for 3 days.
Results: SNE and pregabalin produced analgesic properties observed as increased paw withdrawal latencies to mechanical, tactile, cold water stimuli and thermal hyperalgesic tests during the 5 days of treatment.
Conclusions: The findings suggest that hydro-ethanolic extract of S. nodiflora possesses anti-hyperalgesic and anti-allodynic effects in vincristine-induced neuropathic pain in rats.
Acknowledgments
The authors wish to show their appreciation to Godfred Onso-Nyameye, David Osafo Owusu, Elvis Selase Nyaku and Emmanuel Botchwey for assisting in the laboratory work.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission. The funding organisation(s) played no role in the study design; in the collection, analysis and interpretation of data; in the writing of the report or in the decision to submit the report for publication.
Research funding: This research was supported by the International Foundation for Science, Stockholm, Sweden, through a grant (# F/5191-1) to Dr. Patrick Amoateng.
Employment or leadership: None declared.
Honorarium: None declared.
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©2015 by De Gruyter
Artikel in diesem Heft
- Frontmatter
- Behavior and Neuroprotection
- Evaluation of analgesic activity of levofloxacin in human experimental pain model
- Cardiovascular-Pulmonary Interactions
- Normal spirometric standards in young adult Indian population
- Oxidative Stress
- Antioxidant, antinociceptive and anti-inflammatory properties of the aqueous and ethanolic leaf extracts of Andrographis paniculata in some laboratory animals
- Geraniol attenuates oxidative stress by Nrf2 activation in diet-induced experimental atherosclerosis
- Comparative assessment of onion and garlic extracts on endogenous hepatic and renal antioxidant status in rat
- Hematological Profile
- Silver nanoparticles influenced rat serum metabolites and tissue morphology
- Inflammation
- Anti-inflammatory and antipyretic properties of Corchorus olitorius aqueous root extract in Wistar rats
- Evaluation of anti-inflammatory and analgesic activities and the phytochemical study of Astragalus arbusculinus gum in animal models
- Phytotherapy
- Effects of sub-acute methanol extract treatment of Calliandra portoricensis root bark on antioxidant defence capacity in an experimental rat model
- A hydro-ethanolic extract of Synedrella nodiflora (L.) Gaertn ameliorates hyperalgesia and allodynia in vincristine-induced neuropathic pain in rats
- In vitro assessment of anticholinesterase and NADH oxidase inhibitory activities of an edible fern, Diplazium esculentum
- Original Article
- Identification and evaluation of potentially inappropriate medications (PIMs) in hospitalized geriatric patients using Beers criteria
- Short Communication
- Nerve growth factor-induced myoprotection in C2C12 muscle cells is mediated by α9β1 integrin via release of PGE2
Artikel in diesem Heft
- Frontmatter
- Behavior and Neuroprotection
- Evaluation of analgesic activity of levofloxacin in human experimental pain model
- Cardiovascular-Pulmonary Interactions
- Normal spirometric standards in young adult Indian population
- Oxidative Stress
- Antioxidant, antinociceptive and anti-inflammatory properties of the aqueous and ethanolic leaf extracts of Andrographis paniculata in some laboratory animals
- Geraniol attenuates oxidative stress by Nrf2 activation in diet-induced experimental atherosclerosis
- Comparative assessment of onion and garlic extracts on endogenous hepatic and renal antioxidant status in rat
- Hematological Profile
- Silver nanoparticles influenced rat serum metabolites and tissue morphology
- Inflammation
- Anti-inflammatory and antipyretic properties of Corchorus olitorius aqueous root extract in Wistar rats
- Evaluation of anti-inflammatory and analgesic activities and the phytochemical study of Astragalus arbusculinus gum in animal models
- Phytotherapy
- Effects of sub-acute methanol extract treatment of Calliandra portoricensis root bark on antioxidant defence capacity in an experimental rat model
- A hydro-ethanolic extract of Synedrella nodiflora (L.) Gaertn ameliorates hyperalgesia and allodynia in vincristine-induced neuropathic pain in rats
- In vitro assessment of anticholinesterase and NADH oxidase inhibitory activities of an edible fern, Diplazium esculentum
- Original Article
- Identification and evaluation of potentially inappropriate medications (PIMs) in hospitalized geriatric patients using Beers criteria
- Short Communication
- Nerve growth factor-induced myoprotection in C2C12 muscle cells is mediated by α9β1 integrin via release of PGE2
