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Identification and evaluation of potentially inappropriate medications (PIMs) in hospitalized geriatric patients using Beers criteria

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Veröffentlicht/Copyright: 7. Mai 2015
Journal of Basic and Clinical Physiology and Pharmacology
Aus der Zeitschrift Journal of Basic and Clinical Physiology and Pharmacology Band 26 Heft 4

Abstract

Background: The aim of the study was to identify and evaluate potentially inappropriate medication (PIM) in geriatric patients using Beers criteria and also to identify adverse drug events (ADEs) due to PIMs and various drug-drug interactions.

Methods: The medications in the prescriptions of patients above 60 years of age, their dosage regimen respective of their diagnosis were analyzed. Each medication was then checked with Beers list tables, and any medication if mentioned in the Beers list, was noted along with its strength of recommendation and quality of evidence. Any adverse drug event (ADE) due to PIM was identified. Causality of the events was assessed by Naranjo’s Scale. The number of drug-drug interactions per prescription and the severity of each interaction were also analyzed. The collected data from 200 subjects were subjected to statistical treatments using Statistical Package for Social Sciences (SPSS) software version 16.0 for WINDOWS.

Results: Based on the Beers criteria 2012, 106 out of 200 (53%) prescriptions had at least one PIM prescribed. A sum of 1690 medications was prescribed as a whole for the entire study subjects. Among which, 134 PIMs were identified. Most commonly prescribed PIMs were benzodiazepines (39, 19.5%), followed by sliding scale use of insulin (31, 15.5%), and prazosin at a rate of 11.5% (23). A total of 10 ADEs were identified during the study. The average number of drug interactions observed among total samples was found to be 3.0±6.0 with 0±5.0 serious interactions, 2±4.0 significant interactions requiring close monitoring, and 0±6.0 minor interactions.

Conclusions: The study shows high prevalence of prescribing PIMs in hospitalized elderly patients; PIM also caused incidence of ADEs; and serious drug-drug interactions were scarce among the patients.

Keywords: adverse drug events; Beers criteria; elderly; potentially inappropriate medications
Corresponding author: Dr. Chandrasekhar Dilip, Prof and Head, Department of Pharmacy Practice, Al Shifa college of Pharmacy, Poonthavanam P.0, Perinthalmanna, Kerala 679325, India, E-mail:

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Received: 2014-4-30
Accepted: 2015-2-12
Published Online: 2015-5-7
Published in Print: 2015-7-1

©2015 by De Gruyter

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  2. Behavior and Neuroprotection
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  4. Cardiovascular-Pulmonary Interactions
  5. Normal spirometric standards in young adult Indian population
  6. Oxidative Stress
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  10. Hematological Profile
  11. Silver nanoparticles influenced rat serum metabolites and tissue morphology
  12. Inflammation
  13. Anti-inflammatory and antipyretic properties of Corchorus olitorius aqueous root extract in Wistar rats
  14. Evaluation of anti-inflammatory and analgesic activities and the phytochemical study of Astragalus arbusculinus gum in animal models
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  16. Effects of sub-acute methanol extract treatment of Calliandra portoricensis root bark on antioxidant defence capacity in an experimental rat model
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  18. In vitro assessment of anticholinesterase and NADH oxidase inhibitory activities of an edible fern, Diplazium esculentum
  19. Original Article
  20. Identification and evaluation of potentially inappropriate medications (PIMs) in hospitalized geriatric patients using Beers criteria
  21. Short Communication
  22. Nerve growth factor-induced myoprotection in C2C12 muscle cells is mediated by α9β1 integrin via release of PGE2
https://doi.org/10.1515/jbcpp-2014-0054
Schlagwörter für diesen Artikel
adverse drug events; Beers criteria; elderly; potentially inappropriate medications

Artikel in diesem Heft

  1. Frontmatter
  2. Behavior and Neuroprotection
  3. Evaluation of analgesic activity of levofloxacin in human experimental pain model
  4. Cardiovascular-Pulmonary Interactions
  5. Normal spirometric standards in young adult Indian population
  6. Oxidative Stress
  7. Antioxidant, antinociceptive and anti-inflammatory properties of the aqueous and ethanolic leaf extracts of Andrographis paniculata in some laboratory animals
  8. Geraniol attenuates oxidative stress by Nrf2 activation in diet-induced experimental atherosclerosis
  9. Comparative assessment of onion and garlic extracts on endogenous hepatic and renal antioxidant status in rat
  10. Hematological Profile
  11. Silver nanoparticles influenced rat serum metabolites and tissue morphology
  12. Inflammation
  13. Anti-inflammatory and antipyretic properties of Corchorus olitorius aqueous root extract in Wistar rats
  14. Evaluation of anti-inflammatory and analgesic activities and the phytochemical study of Astragalus arbusculinus gum in animal models
  15. Phytotherapy
  16. Effects of sub-acute methanol extract treatment of Calliandra portoricensis root bark on antioxidant defence capacity in an experimental rat model
  17. A hydro-ethanolic extract of Synedrella nodiflora (L.) Gaertn ameliorates hyperalgesia and allodynia in vincristine-induced neuropathic pain in rats
  18. In vitro assessment of anticholinesterase and NADH oxidase inhibitory activities of an edible fern, Diplazium esculentum
  19. Original Article
  20. Identification and evaluation of potentially inappropriate medications (PIMs) in hospitalized geriatric patients using Beers criteria
  21. Short Communication
  22. Nerve growth factor-induced myoprotection in C2C12 muscle cells is mediated by α9β1 integrin via release of PGE2
Heruntergeladen am 18.4.2026 von https://www.degruyterbrill.com/document/doi/10.1515/jbcpp-2014-0054/html
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