Anti-inflammatory and antipyretic properties of Corchorus olitorius aqueous root extract in Wistar rats
-
Bamidele V. Owoyele
,
Modupe L. Alimi
Abstract
Background: This study was designed to provide information about the antipyretic and anti-inflammatory effects of Corchorus olitorius root.
Methods: Thirty male Wistar rats were divided into six groups of five animals each; the control and reference groups were administered normal saline (10 mL/kg) and indomethacin (5 mg/kg), respectively, whereas the remaining four groups were administered aqueous extract of C. olitorius at doses of 25, 50, 100, or 200 mg/kg, respectively. Pyrexia was induced by injecting 10 mL/kg of 20% (w/v) brewer’s yeast suspension into the dorsum of rats, whereas inflammation was induced through an injection of 0.1% carrageenan into the right hind paw of each rat and through a subcutaneous implantation of a 30-g sterilized cotton pellet into the groin of each rat.
Results: The results showed that C. olitorius root extract (p<0.05) decreased the elevated temperature after brewer’s yeast injection compared with the 17 h (pre-drug) temperature. In the inflammatory tests, the paw sizes and granuloma weights in the test groups were significantly (p<0.05) decreased compared with the control group.
Conclusions:Corchorus olitorius root is another good source of phytomedicine that can be used effectively to treat inflammation and pyrexia that accompany some diseases.
References
1. Axelrod YK, Diringer MN. Temperature management in acute neurologic disorders. Neurol Clin 2008;26:585.10.1016/j.ncl.2008.02.005Search in Google Scholar
2. Charles AD, Jeffrey AG. Fever and hyperthermia. In: Kasper DL, Braunwald E, Fauci AS, Hauser SL, Longo DL, Jameson JL, editors. Harrison’s manual of medicine, 16th ed. New York: McGraw Hill, 2008:105–9.Search in Google Scholar
3. Karakitsos D, Karabinis A. Hypothermia therapy after traumatic brain injury in children. N Engl J Med 2008;359:1179.10.1056/NEJMc081418Search in Google Scholar
4. Emdad H, Subhash CM, Gupta JK. Phytochemical screening and in-vivo antipyretic activity of the methanol leaf-extract of Bombax malabaricum DC (Bombacaceae). Trop J Pharmaceut Res 2011;10:55–60.10.4314/tjpr.v10i1.66541Search in Google Scholar
5. O’Byrne KJ, Dalgleish AG. Chronic immune activation and inflammation as the cause of malignancy. Br J Cancer 2001;85:473–83.10.1054/bjoc.2001.1943Search in Google Scholar
6. O’Byrne KJ, Dalgleish AG, Browning MJ, Steward WP, Harris AL. The relationship between angiogenesis and the immune response in carcinogenesis and the progression of malignant disease. Eur J Cancer 2000;36:151–69.10.1016/S0959-8049(99)00241-5Search in Google Scholar
7. Libby P. Inflammatory mechanisms: the molecular basis of inflammation and disease. Nutr Rev 2007;65:S140–6.10.1111/j.1753-4887.2007.tb00352.xSearch in Google Scholar
8. Paterson HM, Murphy TJ, Purcell EJ, Shelley O, Kriynovich SJ, Lien E, et al. Injury primes the innate immune system for enhanced Toll-like receptor reactivity. J Immunol 2003;171:1473–83.10.4049/jimmunol.171.3.1473Search in Google Scholar
9. Ferrero-Miliani L, Nielsen OH, Andersen PS, Girardin SE. Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1β generation. Clin Exp Immunol 2006;147:227–35.10.1111/j.1365-2249.2006.03261.xSearch in Google Scholar
10. Abbas AB, Lichtman Ah, editors. Ch.2 innate immunity. In: Basic immunology. Functions and disorders of the immune system, 3rd ed. Waltham, MA: Saunders (Elsevier), 2009.Search in Google Scholar
11. Dalgleish AG, O’Byrne KJ. Chronic immune activation and inflammation in the pathogenesis of AIDS and cancer. Adv Cancer Res 2002;84:231–76.10.1016/S0065-230X(02)84008-8Search in Google Scholar
12. Oboh G, Ademiluyi AO, Akinyemi AJ, Henle T, Saliu JA, Schwarzenbolz U. Inhibitory effect of polyphenol-rich extracts of jute leaf (Corchorus olitorius) on key enzyme linked to type 2 diabetes (a-amylase and aglucosidase) and hypertension (angiotensin I converting) in vitro. J Funct Food 2012;4:450–8.10.1016/j.jff.2012.02.003Search in Google Scholar
13. Madhu T. Bio-composites, an overview. Text Mag 2002:8–49.Search in Google Scholar
14. Gbadamosi IT, Alia AE, Okolosi O. In-vitro antimicrobial activities and nutritional assessment of roots of ten Nigerian vegetables. NY Sci J 2012;5:234–40.Search in Google Scholar
15. Das AK, Bag S, Sahu R, Dua TK, Sinha MK, Gangopadhyay M, et al. Protective effect of Corchorus olitorius leaves on sodium arsenite-induced toxicity in experimental rats. Food Chem Toxicol 2010:326–35.10.1016/j.fct.2009.10.020Search in Google Scholar PubMed
16. Zakaria ZA, Safarul M, Valsala R, Sulaiman MR, Fatimah CA, Somchit MN, et al. The influences of temperature and naloxone on the antinociceptive activity of Corchorus olitorius L. in mice. Naunyn-Schmiedeberg’s Arch Pharmacol 2005;372:55–62.10.1007/s00210-005-1089-8Search in Google Scholar PubMed
17. Zakaria, ZA, Somchi, MN, Zaiton, H, Mat-Jais AM, Sulaiman MR, Farah WO, et al. The in vitro antibacterial activity of Corchorus olitorius extracts. Int J Pharmacol 2006;2:213–5.10.3923/ijp.2006.213.215Search in Google Scholar
18. Dewanjee S, Sahu R, Karmakar S, Gangopadhyay M. Toxic effects of lead exposure in Wistar rats: involvement of oxidative stress and the beneficial role of edible jute (Corchorus olitorius) leaves. Food Chem Toxicol 2013;55:78–91.10.1016/j.fct.2012.12.040Search in Google Scholar PubMed
19. Laskar S, Majumdar SG, Basak B, Dey CD. Influence of jute (Corchorus olitorius) seed protein enriched diet on some enzymes and liver lipids of albino rats (Rattus norvegicus). Physiol Bohemoslov 1986;35:86–9.Search in Google Scholar
20. Tijani AY, Uguru MO, Salawu OA. Anti-pyretic, anti-inflammatory and anti-diarrhoeal properties of Faidherbia albida in rats. Afr J Biotechnol 2008;7:696–700.Search in Google Scholar
21. Winter CA, Risley EA, Nuss GW. Carrageen-induced oedema in hind paw of the rats – an assay for anti-inflammatory drugs. Proc Soc Exp Biol Med 1962;111:544–47.10.3181/00379727-111-27849Search in Google Scholar PubMed
22. Odeh M. The role of tumor necrosis factor-a in the pathogenesis of complicated Falciparum malaria. Cytokine 2001;14: 11–8.10.1006/cyto.2001.0845Search in Google Scholar PubMed
23. Kulander L, Pauksens K, Venge P. Soluble adhesion molecules, cytokines and cellular markers in serum in patients with acute infections. Scand J Infect Dis 2001;33:290–300.10.1080/003655401300077342Search in Google Scholar PubMed
24. Lehmann FS, Stalder GA. Hypothesis on the role of cytokines in peptic ulcer disease. Eur J Clin Invest 1998;28:511–9.10.1046/j.1365-2362.1998.00306.xSearch in Google Scholar PubMed
25. Gabriel AS, Ahnve S, Wretlind B, Martinsson A. IL-6 and IL-1 receptor antagonist instable angina pectoris and relation of IL-6 to clinical findings in acute myocardial infarction. J Int Med 2000;248:61–6.10.1046/j.1365-2796.2000.00701.xSearch in Google Scholar PubMed
26. Iwalewa EO, McGaw LJ, Naidoo V, Eloff JN. Inflammation: the foundation of diseases and disorders. A review of phytomedicines of South African origin used to treat pain and inflammatory conditions. Afr J Biotechnol 2007;6:2868–85.10.5897/AJB2007.000-2457Search in Google Scholar
27. Owoyele BV, Okoye OC, Dolor RO, Oloruntola OP, Soladoye AO. Analgesic, anti-inflammatory and antipyretic effects of the ethanol extract of Acalypha wilkesiana leaves in rats. Nig J Physiol Sci 2011;26:77–82.Search in Google Scholar
28. Junaid N, Vikas G, Prithviraj C, Pawan K. Anti-inflammatory and antipyretic activity of aleuritis moluccana leaves. Asian J Pharmaceut Clin Res 2010;3:35–7.Search in Google Scholar
29. Patra A, Jha S, Murthy PM, Vaibhav A, Chattopadhyay P, Panigrahi G, et al. Anti-inflammatory and antipyretic activities of Hygrophila spinosa T. Anders leaves (Acanthaceae). Trop J Pharmaceut Res 2009;8:133–7.10.4314/tjpr.v8i2.44521Search in Google Scholar
30. Akinyemi AI, Ogundare AO. Antibacterial properties of the leaf extracts of Anthocleista djalonensis A. Chev on some pathogenic organisms. Eur J Med Plants 2014;4:75–85.10.9734/EJMP/2014/4250Search in Google Scholar
©2015 by De Gruyter
Articles in the same Issue
- Frontmatter
- Behavior and Neuroprotection
- Evaluation of analgesic activity of levofloxacin in human experimental pain model
- Cardiovascular-Pulmonary Interactions
- Normal spirometric standards in young adult Indian population
- Oxidative Stress
- Antioxidant, antinociceptive and anti-inflammatory properties of the aqueous and ethanolic leaf extracts of Andrographis paniculata in some laboratory animals
- Geraniol attenuates oxidative stress by Nrf2 activation in diet-induced experimental atherosclerosis
- Comparative assessment of onion and garlic extracts on endogenous hepatic and renal antioxidant status in rat
- Hematological Profile
- Silver nanoparticles influenced rat serum metabolites and tissue morphology
- Inflammation
- Anti-inflammatory and antipyretic properties of Corchorus olitorius aqueous root extract in Wistar rats
- Evaluation of anti-inflammatory and analgesic activities and the phytochemical study of Astragalus arbusculinus gum in animal models
- Phytotherapy
- Effects of sub-acute methanol extract treatment of Calliandra portoricensis root bark on antioxidant defence capacity in an experimental rat model
- A hydro-ethanolic extract of Synedrella nodiflora (L.) Gaertn ameliorates hyperalgesia and allodynia in vincristine-induced neuropathic pain in rats
- In vitro assessment of anticholinesterase and NADH oxidase inhibitory activities of an edible fern, Diplazium esculentum
- Original Article
- Identification and evaluation of potentially inappropriate medications (PIMs) in hospitalized geriatric patients using Beers criteria
- Short Communication
- Nerve growth factor-induced myoprotection in C2C12 muscle cells is mediated by α9β1 integrin via release of PGE2
Articles in the same Issue
- Frontmatter
- Behavior and Neuroprotection
- Evaluation of analgesic activity of levofloxacin in human experimental pain model
- Cardiovascular-Pulmonary Interactions
- Normal spirometric standards in young adult Indian population
- Oxidative Stress
- Antioxidant, antinociceptive and anti-inflammatory properties of the aqueous and ethanolic leaf extracts of Andrographis paniculata in some laboratory animals
- Geraniol attenuates oxidative stress by Nrf2 activation in diet-induced experimental atherosclerosis
- Comparative assessment of onion and garlic extracts on endogenous hepatic and renal antioxidant status in rat
- Hematological Profile
- Silver nanoparticles influenced rat serum metabolites and tissue morphology
- Inflammation
- Anti-inflammatory and antipyretic properties of Corchorus olitorius aqueous root extract in Wistar rats
- Evaluation of anti-inflammatory and analgesic activities and the phytochemical study of Astragalus arbusculinus gum in animal models
- Phytotherapy
- Effects of sub-acute methanol extract treatment of Calliandra portoricensis root bark on antioxidant defence capacity in an experimental rat model
- A hydro-ethanolic extract of Synedrella nodiflora (L.) Gaertn ameliorates hyperalgesia and allodynia in vincristine-induced neuropathic pain in rats
- In vitro assessment of anticholinesterase and NADH oxidase inhibitory activities of an edible fern, Diplazium esculentum
- Original Article
- Identification and evaluation of potentially inappropriate medications (PIMs) in hospitalized geriatric patients using Beers criteria
- Short Communication
- Nerve growth factor-induced myoprotection in C2C12 muscle cells is mediated by α9β1 integrin via release of PGE2
