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Ketamine and the core symptoms of autism

  • Theodore Kastner EMAIL logo , Kevin Walsh , Lisa Shulman , Farah Alam und Samuel Flood
Veröffentlicht/Copyright: 8. September 2015

Abstract

Autism or autism spectrum disorder (ASD) is a behavioral syndrome characterized by (a) persistent deficits in social communication and social interaction across multiple contexts and (b) restricted, repetitive patterns of behavior, interests or activities. However, the etiology of autism in most cases remains unknown. Ketamine, an N-Methyl-D-aspartate (NMDA) blocker, has been purported by some as a possible treatment for autism. This conclusion is premature. Here, we present a single case study in which a patient with a severe intellectual disability was said to have demonstrated a dramatic, albeit short-lived, remission of the core symptoms of autism following adventitious treatment with ketamine. Although this anecdote is encouraging, we argue that further analysis of ketamine as a treatment for autism is needed.


Corresponding author: Theodore Kastner, MD, MS, Albert Einstein College of Medicine, Department of Pediatrics, 1300 Morris Park Avenue, Bronx, NY 10461, USA, E-mail:

References

1. American Psychiatric Association. The diagnostic and statistical manual of mental disorders: DSM V. Arlington, VA: American Psychiatric Association, 2013.10.1176/appi.books.9780890425596Suche in Google Scholar

2. Rimland B, Baker SM. Brief report: alternative approaches to the development of effective treatments for autism. J Autism Dev Disord 1996;26:237–41.10.1007/BF02172019Suche in Google Scholar PubMed

3. Reichelt KL, Ekrem J, Scott H. Gluten, milk proteins and autism: dietary intervention effects on behavior and peptide secretion. J Appl Nutr 1990;42:1–11.Suche in Google Scholar

4. Beck G, Beck V. Unlocking the potential of secretin: information and questions for parents and physicians who want to learn more about secretin as its use is explored in autism and other disorders. San Diego, CA: Autism Research Institute, 1996.Suche in Google Scholar

5. Chez MG, Buchanan CP, Bagan BT, Hammer MS, McCarthy KS, Ovrutskaya I, et al. (2000). Secretin and autism: a two-part clinical investigation. J Autism Dev Disord 2000;30:87–94.Suche in Google Scholar

6. Dunn-Geier J, Ho HH, Auersperg E, Doyle D, Eaves L, Matsuba D, et al. The effect of secretin on children with autism: a randomized controlled trial. Dev Med Child Neurol 2000;42:796–802.10.1111/j.1469-8749.2000.tb00692.xSuche in Google Scholar

7. Roberts W, Weaver L, Brian J, Bryson S, Emelianova S, Griffiths AM, et al. Repeated doses of porcine secretin in the treatment of autism: a randomized, placebo-controlled trial. Pediatrics 2001;107:E71.10.1542/peds.107.5.e71Suche in Google Scholar PubMed

8. Nakako T, Murai T, Ikejiri M, Ishiyama T, Taiji M, Ikeda K. Effects of a dopamine D1 agonist on ketamine-induced spatial working memory dysfunction in common marmosets. Behav Brain Res 2013;249:109–15.10.1016/j.bbr.2013.04.012Suche in Google Scholar PubMed

9. Wink LK, O’Melia AM, Shaffer RC, Pedapati E, Friedmann K, Schaefer T, et al. Intranasal ketamine treatment in an adult with autism spectrum disorder. J Clin Psychiatry 2014;75:835–6.10.4088/JCP.13cr08917Suche in Google Scholar PubMed

10. Pollack A. Special k, a hallucinogen, raises hope and concerns as a treatment for depression. The New York Times, 9 Dec 2014, p. B1.Suche in Google Scholar

Received: 2015-3-21
Accepted: 2015-6-6
Published Online: 2015-9-8
Published in Print: 2016-2-1

©2016 by De Gruyter

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