Prevalence and risk factors of polycystic ovarian syndrome among an ethnically diverse overweight/obese adolescent population
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Jacqueline Maya
,
Janet Siegel
Abstract
Background
More remains to be known about polycystic ovary syndrome (PCOS) among overweight/obese adolescents across different ethnicities especially in regards to mental illness as an associated comorbidity.
Objective
To determine the prevalence of PCOS among overweight and obese adolescents and to evaluate known risk factors for PCOS in a diverse population.
Methods
Charts of patients at an Adolescent Clinic between April 1, 2016 and July 30, 2018 were filtered using: obese, overweight and body mass index (BMI) >85%. Charts were reviewed to identify the presence of PCOS using National Institutes of Health (NIH) criteria, race/ethnicity and known risk factors for PCOS [lipid, BMI, glycated hemoglobin (HA1c), blood pressure (BP)] and mental health conditions associated with PCOS (anxiety/depression and self-harm/suicidal ideation).
Results
Patients with PCOS were more likely to have elevated lipids (19.6% vs. 9.9%, p = 0.05), be obese (67.4% vs. 50.9%, p = 0.03), and have acanthosis nigricans (68.9% vs. 28.2%, p =< 0.001). PCOS was more common among non-Hispanic patients (77.9%) vs. Hispanic patients (57.8%). There was no difference in the prevalence of depression/anxiety (37% vs. 33%, respectively, p = 0.590) or self – harm/suicidal ideation (17% vs. 17%, p = 0.96) in patients with and without PCOS. In a logistic regression model, after adjusting for all demographics and clinical features, ethnicity, acanthosis nigricans and BMI were significant risk factors for PCOS.
Conclusion
Patients with PCOS are more likely to be obese, hyperlipidemic, have acanthosis nigricans and be of non-Hispanic ethnicity. However, there was no difference in the prevalence of depression/anxiety and self-harm/suicidal ideation among adolescents with or without PCOS.
Acknowledgment
Statistical Support Provided by the Department of Pediatrics-Icahn School of Medicine at Mount Sinai.
References
[1] Ding T, Hardiman PJ, Petersen I, Wang FF, Qu F, Baio G. The prevalence of polycystic ovary syndrome in reproductive-aged women of different ethnicity: a systematic review and meta-analysis. Oncotarget. 2017;8(56):96351–58.10.18632/oncotarget.19180Suche in Google Scholar PubMed PubMed Central
[2] Wang S, ALvero R. Racial and ethnic differences in physiology and clinical symptoms of polycystic ovary syndrome. Emin Reprod Med. 2013;31:365–9.10.1055/s-0033-1348895Suche in Google Scholar PubMed
[3] Ybarra M, Franco RR, Cominato L, Sampaio RB, Sucena da Rocha SM, Damiani D. Polycystic Ovary Syndrome among obese adolescents. Gynecol Endocrinol. 2017;34(1):45–8.10.1080/09513590.2017.1359250Suche in Google Scholar PubMed
[4] Mehta J, Kamdar V, Dumesic D. Phenotypic expression of polycystic ovary syndrome in south East Asian women. Obstet Gynecol Surv. 2013;68(3):228–34.10.1097/OGX.0b013e318280a30fSuche in Google Scholar PubMed
[5] Javed A, Chelvakumar G, Bonny AE. Polycystic ovary syndrome in adolescents: a review of past year evidence. Curr Opin Obstet Gynecol. 2016;28:373–80.10.1097/GCO.0000000000000301Suche in Google Scholar PubMed
[6] Lizneva D, Suturina L, Walker W, Brakta S, Gavrilova-Jordan L, Azziz R. Criteria, prevalence, and phenotypes of polycystic ovary syndrome. Fertil Steril. 2016;106:6–15.10.1016/j.fertnstert.2016.05.003Suche in Google Scholar PubMed
[7] Nur MM, Newman IN, Siqueira L. Glucose metabolism in overweight Hispanic adolescents with and without polycystic ovary syndrome. Pediatrics. 2009;124(3):e496–502.10.1542/peds.2008-2050Suche in Google Scholar PubMed
[8] Mani H, Davies M, Bodicoat DH, Levy MJ, Gray LJ, Howlett TA, et al. Clinical characteristics of polycystic ovary syndrome: investigating differences in White and South Asian women. Clin Endocrinol. 2015;83:542–9.10.1111/cen.12784Suche in Google Scholar PubMed
[9] Jedel E, Waern M, Gustafson D, Landen M, Eriksson E, Holm G, et al. Anxiety and depression symptoms in women with polycystic ovary syndrome compared with controls matched for body max index. Hum Reprod. 2010;25(2):450–6.10.1093/humrep/dep384Suche in Google Scholar PubMed
[10] Hollinrake E, Abreu A, Maifeld M, Van Voorhis BJ, Dokras A. Increased risk of depressive disorders in women with polycystic ovary syndrome. Fertil Steril. 2007;87(6):1369–76.10.1016/j.fertnstert.2006.11.039Suche in Google Scholar PubMed
[11] Brutocao C, Zaiem F, Alsawas M, Morrow AS, Murad HM, Javed A. Psychiatric disorders in women with polycystic ovary syndrome: a systematic review and meta-analysis. Endocrine. 2018;62:318–25.10.1007/s12020-018-1692-3Suche in Google Scholar PubMed
[12] Milsom SR, Nair SM, Ogilvie CM, Stewart JM, Merry SN. Polycystic ovary syndrome and depression in New Zealand adolescents. J Pediatr Adol Gynec. 2013;26:142–7.10.1016/j.jpag.2012.11.013Suche in Google Scholar PubMed
[13] Banba V. Update on screening, etiology, and treatment of dyslipidemia in children. J Clin. Endocrinol. 2014;99:3093–102.10.1210/jc.2013-3860Suche in Google Scholar PubMed
[14] Copeland KC, Silverstein J, Moore KR, Prazar GE, Raymer T, Shiffman RN, et al. Clinical practice guideline: management of newly diagnosed type 2 diabetes mellitus (T2DM) in children and adolescents. Pediatrics. 2013;131(2):364–82.10.1542/peds.2012-3494Suche in Google Scholar PubMed
[15] Zuckerbrot RA, Cheung A, Jensen PS, Stein RE, Laraque D. Guidelines for Adolescent Depression in Primary Care (GLAD-PC): Part I. Practice Preparation, Identification, Assessment, and Initial Management. Pediatrics. 2018;141(3):e20174081.10.1542/peds.2017-4081Suche in Google Scholar PubMed
[16] Gilbody S, Richards D, Brealey S, Hewitt C. Screening for depression in medical settings with the Patient Health Questionnaire (PHQ): a diagnostic meta-analysis. J Gen Intern Med. 2007;11:1596–602.10.1007/s11606-007-0333-ySuche in Google Scholar PubMed PubMed Central
[17] Manea L, Gilbody S, McMillan D. Optimal cut-off score for diagnosing depression with the Patient Health Questionnaire (PHQ-9): a meta-analysis. Can Med Assoc J. 2012;184(3):E191–6.10.1503/cmaj.110829Suche in Google Scholar PubMed PubMed Central
[18] Mossman SA, Luft MJ, Schroeder HK, Varney ST, Fleck DE, Barzman DH, et al. The Generalized Anxiety Disorder 7-itm (GAD-7) scale in adolescents with generalized anxiety disorder: signal detection and validation. Ann Clin Psychiatry. 2017;29(4):227–34A.Suche in Google Scholar
[19] Moran C, Tena G, Moran S, Ruiz P, Reyna R, Duque X. Prevalence of polycystic ovary. Gynecol Obstet Invest. 2010;69:274–80.10.1159/000277640Suche in Google Scholar PubMed
[20] Goodarzi MO, Quinones MJ, Azziz R, Rotter JI, Hsueh WA, Yang H. Polycystic ovary syndrome and related disorders in Mexican Women. Syndrome and related disorders in Mexican-Americans: prevalence and association with the severity of insulin resistance. Fertil Steril. 2005;83:766–9.10.1016/j.fertnstert.2005.03.051Suche in Google Scholar PubMed
[21] Rodin DA, Bano G, Bland JM, Taylor K, Nussey SS. Polycystic ovaries and associated metabolic abnormalities in Indian subcontinent Asian women. Clin Endocrinol. 1998;49:91–9.10.1046/j.1365-2265.1998.00492.xSuche in Google Scholar PubMed
[22] Yang AY, OShiro J, Ayers C, Auchus RJ. Influence of race/ethnicity on cardiovascular risk factors in polycystic ovary syndrome, the Dallas Heart Study. Clin Endocrinol. 2016;85(1):92–9.10.1111/cen.12986Suche in Google Scholar PubMed PubMed Central
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Artikel in diesem Heft
- Frontmatter
- Original Articles
- Necessity for redesigning premarital counseling classes based on marriage readiness from the perspective of adolescents and specialists: a need assessment based on the Bourich model and quadrant analysis
- Knowledge and attitude of Egyptian parents toward childhood mental disorders
- The association of resilience with health-related quality of life (HRQoL) in adolescent students
- Self-esteem and motivation with adherence of people living with HIV/AIDS (PLWHA) in Indonesia with antiretroviral therapy: a cross-sectional study
- Rethinking early childbearing in Indonesia: is it preceded by a premarital first birth?
- Effectiveness of different methods of health education on knowledge and attitude regarding palliative care among college students in urban Puducherry: a pre-post intervention study
- Prevalence and correlates of being bullied among adolescents in Indonesia: results from the 2015 Global School-based Student Health Survey
- Effect of acupressure on post tonsillectomy pain in adolescents: a randomized, single-blind, placebo-controlled trial study
- Perceived stress and coping strategies among undergraduate dental students – an institutional based study
- Effects of carrying school bags on cervical and shoulder posture in static and dynamic conditions in adolescent students
- Validation of the Arabic version of the Bergen Facebook Addiction Scale in Tunisian adolescents
- Determining predictors of change in sugar sweetened beverage consumption behaviour among university students in India
- Association between menstrual disorders and school absenteeism among schoolgirls in South Egypt
- The association between iron deficiency anemia and febrile seizure
- Experience of bullying among Bhutanese college students: implications for teacher formation programmes
- Does an association exist between socio-economic status and subjective physical, mental and social well-being among early adolescents?
- The effect of acceptance and commitment therapy on the mental health of students with an emotional breakdown
- Sleep quality and its effect on event related potential P300 in adolescents with and without sleep disturbances
- The effect of rational-emotive behavior therapy on anxiety and resilience in students
- The use of gadgets and their relationship to poor sleep quality and social interaction on mid-adolescents: a cross-sectional study
- Knowledge and attitude regarding reproductive and sexual health among school teachers: a descriptive survey
- Inadequate awareness of cervical cancer and its prevention among young women of Delhi, India: public health policy implications
- Prevalence and risk factors of polycystic ovarian syndrome among an ethnically diverse overweight/obese adolescent population
- Comparison of the effect of self-care education in a disaster with two student-centered and family-centered approaches to self-care in students
- The effect of life skills training with health literacy strategies on self-esteem and self-efficacy in female students during puberty
Artikel in diesem Heft
- Frontmatter
- Original Articles
- Necessity for redesigning premarital counseling classes based on marriage readiness from the perspective of adolescents and specialists: a need assessment based on the Bourich model and quadrant analysis
- Knowledge and attitude of Egyptian parents toward childhood mental disorders
- The association of resilience with health-related quality of life (HRQoL) in adolescent students
- Self-esteem and motivation with adherence of people living with HIV/AIDS (PLWHA) in Indonesia with antiretroviral therapy: a cross-sectional study
- Rethinking early childbearing in Indonesia: is it preceded by a premarital first birth?
- Effectiveness of different methods of health education on knowledge and attitude regarding palliative care among college students in urban Puducherry: a pre-post intervention study
- Prevalence and correlates of being bullied among adolescents in Indonesia: results from the 2015 Global School-based Student Health Survey
- Effect of acupressure on post tonsillectomy pain in adolescents: a randomized, single-blind, placebo-controlled trial study
- Perceived stress and coping strategies among undergraduate dental students – an institutional based study
- Effects of carrying school bags on cervical and shoulder posture in static and dynamic conditions in adolescent students
- Validation of the Arabic version of the Bergen Facebook Addiction Scale in Tunisian adolescents
- Determining predictors of change in sugar sweetened beverage consumption behaviour among university students in India
- Association between menstrual disorders and school absenteeism among schoolgirls in South Egypt
- The association between iron deficiency anemia and febrile seizure
- Experience of bullying among Bhutanese college students: implications for teacher formation programmes
- Does an association exist between socio-economic status and subjective physical, mental and social well-being among early adolescents?
- The effect of acceptance and commitment therapy on the mental health of students with an emotional breakdown
- Sleep quality and its effect on event related potential P300 in adolescents with and without sleep disturbances
- The effect of rational-emotive behavior therapy on anxiety and resilience in students
- The use of gadgets and their relationship to poor sleep quality and social interaction on mid-adolescents: a cross-sectional study
- Knowledge and attitude regarding reproductive and sexual health among school teachers: a descriptive survey
- Inadequate awareness of cervical cancer and its prevention among young women of Delhi, India: public health policy implications
- Prevalence and risk factors of polycystic ovarian syndrome among an ethnically diverse overweight/obese adolescent population
- Comparison of the effect of self-care education in a disaster with two student-centered and family-centered approaches to self-care in students
- The effect of life skills training with health literacy strategies on self-esteem and self-efficacy in female students during puberty
