The significant role of educational status in PKU patients: the beneficial effect of psychological support in depression
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Kostas Iakovou
und
Kleopatra Schulpis
Abstract
Introduction
Classical Phenylketonuria (PKU) is a metabolic disease characterized by high phenylalanine (phe) levels in blood and brain. PKU patients are commonly treated with low phe diet supplemented with amino acid free formula. High Phe levels minimize brain tryptophan concentration, the pressure of serotonin, which is responsible for the appearance of depression symptoms. Both amino acids share the same pathway for entering CNS via BBB. Aimed to determine the effect of psychological support on different education status depressed PKU patients via adherence to their diet.
Methods
PKU patients (n = 110) were divided into groups according to their education status: Primary school, High school, University degree. All patients were tasted with a Patient Health Questionnaire (PHQ-9) standardized for Greek population. Psychological support was performed in every depressed patient ones per two weeks for three successive months under the same conditions. Phe blood levels were measured before psychological support and every 15–20 days till the end of the study.
Results
Only 2/110 (1.8%) participance had finished Primary school and were healthy. 72/110 (65.5%) High School, out of them 29 were depressed and 36/110 (32.7%) achieved a University degree, only 6 suffered from depression. High phe blood levels were measured in the depressed patients, which dropped near to normal after the end of their psychological support. Referring to depression symptoms, all participance except one presented amelioration of their mood.
Conclusions
Psychological support is beneficial on depressed PKU patients graduated with High School or University degree via adherence to their special diet.
References
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©2019 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
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- Frontmatter
- Editorial
- Pharmacology for obesity: perspectives of history
- Reviews
- Trends and risk factors of adolescent opioid abuse/misuse: understanding the opioid epidemic among adolescents
- The prevalence of neuropathy among type 1 diabetic adolescents in Iran: a systematic review and meta-analysis
- Original Articles
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- Occupational agricultural injuries among the preadolescent workers of West Bengal, India
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- Increased aggressive behavior among youth in the United States who have experienced multiple forms of victimization
- Knowledge and awareness of oral cancer and impact of pictorial warnings on the willingness to quit tobacco in young tobacco consumers in India
- The biopsychosocial condition of childhood cancer survivors in the transition towards adult care: a national survey from the joint pediatric and adult transition care group
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- Women’s reproductive health needs assessment questionnaire: development and validation
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- Will I, Wont I? Factors associated with self-reported prediction of future indulgence in intimate partner violence among adolescents in South India
- High-risk behaviors and demographic features: a cross-sectional study among Iranian adolescents
- Spiritual health: is it a determinant factor for preventing risky behaviors among university students?
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