Abstract
Introduction
Neuropathy is one of the most common complications of diabetes, which causes many problems for diabetic patients. Thus, the aim of the present study was to investigate the prevalence of neuropathy among type 1 diabetic adolescents by systematic review and meta-analysis.
Materials and methods
This study is a systematic review and meta-analysis, which reviewed articles published from 2001 to September 1, 2018. The search process was carried out in the Google Scholar search engine and domestic and international databases such as Magiran, SID, Iranmedex, IranDoc, Medlib, PubMed, Scopus, Science Direct, Springer, Wiley Online Library, Web of Science, Ebsco and Cochrane using Persian and English keywords based on MESH conformity. All the research steps were carried out by two members of the research team who were familiar with systematic reviews and meta-analysis data, using the software CMA. Analysis of meta-regression and the use of a random effects model were introduced and analyzed.
Findings
When a systematic search was carried out on the reviewed articles, five of them were included in the meta-analysis phase. The sample size was 484, and the prevalence of diabetic peripheral neuropathy (DPN) in type 1 diabetic patients was 28.2% [confidence interval (CI) = 19.5–39.1]. The findings of the meta-regression analysis showed that the DPN prevalence rate decreased with increasing age (Q = 5.77 p = 0.016), and the results of more recent studies showed an increase in the DPN incidence rate (Q = 20.62, p < 0.001).
Conclusion
The findings of the present study revealed that although the prevalence of neuropathy in diabetic adolescents was not high, the prevalence was significant. Considering the increasing prevalence of diabetes and its impact on the health status of patients, appropriate interventions should be conducted to prevent diabetes and subsequent diabetic neuropathy.
Funding source: Kermanshah University of Medical Sciences
Award Identifier / Grant number: 3006963
Funding statement: This article was approved by the Student research committee of Kermanshah University of Medical Sciences with the Project Code 3006963, Funder Id: 10.13039/501100005317. Therefore, the researchers are grateful to the center.
References
[1] Mohammadi M, Raiegan V, Akbar A, Mirzaei M, Zahednezhad H, Jalali R, et al. Prevalence of underweight in Iranian children: a systematic review and meta-analysis. Tehran Univ Med J. 2018;76(4):241–9.Suche in Google Scholar
[2] Moţăţăianu A, Maier S, Bajko Z, Voidazan S, Bălaşa R, Stoian A. Cardiac autonomic neuropathy in type 1 and type 2 diabetes patients. BMC Neurol. 2018;18(1):126.10.1186/s12883-018-1125-1Suche in Google Scholar PubMed PubMed Central
[3] Shohani M, Tavan H. Arbitrary use of insulin and its consequence. Iran J Public Health. 2018;47(8):1226–7.Suche in Google Scholar
[4] Cheraghi F, Mortazavi S, Shamsaei F, Moghimbeigi A. Effect of education on management of blood glucose in children with diabetes. J Nurs Educ. 2014;3(1):1–11.Suche in Google Scholar
[5] Esteghamati A, Larijani B, Aghajani MH, Ghaemi F, Kermanchi J, Shahrami A, et al. Diabetes in Iran: prospective analysis from first nationwide diabetes report of National Program for Prevention and Control of Diabetes (NPPCD-2016). Sci Rep. 2017;7(1):13461.10.1038/s41598-017-13379-zSuche in Google Scholar PubMed PubMed Central
[6] Papatheodorou K, Banach M, Edmonds M, Papanas N, Papazoglou D. Complications of diabetes. J Diabetes Res. 2015;2015. DOI: 10.1155/2015/189525.Suche in Google Scholar PubMed PubMed Central
[7] De Groot M, Anderson R, Freedland KE, Clouse RE, Lustman PJ. Association of depression and diabetes complications: a meta-analysis. Psychosom Med. 2001;63(4):619–30.10.1097/00006842-200107000-00015Suche in Google Scholar PubMed
[8] Robinson MÈ, Altenor K, Carpenter C, Bonnell R, Jean‐Baptiste E, von Oettingen J. High rates of ocular complications in a cohort of Haitian children and adolescents with diabetes. Pediatr Diabetes. 2018;19(6):1124–1130. DOI: 10.1111/pedi.12688.Suche in Google Scholar PubMed
[9] Feldman MA, Anderson LM, Shapiro JB, Jedraszko AM, Evans M, Weil LE, et al. Family-based interventions targeting improvements in health and family outcomes of children and adolescents with type 1 diabetes: a systematic review. Curr Diab Rep. 2018;18(3):15.10.1007/s11892-018-0981-9Suche in Google Scholar PubMed
[10] Moayeri A, Mohamadpour M, Mousavi SF, Shirzadpour E, Mohamadpour S, Amraei M. Fracture risk in patients with type 2 diabetes mellitus and possible risk factors: a systematic review and meta-analysis. Ther Clin Risk Manag. 2017;13:455–68.10.2147/TCRM.S131945Suche in Google Scholar PubMed PubMed Central
[11] Amraei M, Mohamadpour S, Sayehmiri K, Mousavi SF, Shirzadpour E, Moayeri A. Effects of vitamin D deficiency on incidence risk of gestational diabetes mellitus: a systematic review and meta-analysis. Front Endocrinol (Lausanne). 2018;9:7.10.3389/fendo.2018.00007Suche in Google Scholar PubMed PubMed Central
[12] Mutlu EK, Unver B, Taskiran H, Ozgen IT. An investigation of the foot ankle joint mobility, muscle strength, and foot structure in adolescent with type 1 diabetes. Int J Diabetes Dev Ctries. 2018;38(1):108–14.10.1007/s13410-017-0556-3Suche in Google Scholar
[13] Elbarbary NS, Ismail EAR, El‐Naggar AR, Hamouda MH, El‐Hamamsy M. The effect of 12 weeks carnosine supplementation on renal functional integrity and oxidative stress in pediatric patients with diabetic nephropathy: a randomized placebo‐controlled trial. Pediatr Diabetes. 2018;19(3):470–7.10.1111/pedi.12564Suche in Google Scholar PubMed
[14] Peng S, Li C, Sun X. Complications of diabetes diagnosed in children and adolescents. J Am Med Assoc. 2017;317(24):2552–3.10.1001/jama.2017.6223Suche in Google Scholar PubMed
[15] Olfatifar M, Karami M, Shokri P, Hosseini SM. Prevalence of chronic complications and related risk factors of diabetes in patients referred to the diabetes center of Hamedan Province. Sci J Hamadan Nurs Midwifery Fac. 2017;25(2):69–74.10.21859/nmj-25029Suche in Google Scholar
[16] Alvarado-Martel D, Velasco R, Sánchez-Hernández RM, Carrillo A, Nóvoa FJ, Wägner AM. Quality of life and type 1 diabetes: a study assessing patients’ perceptions and self-management needs. Patient Prefer Adherence. 2015;9:1315–23.10.2147/PPA.S87310Suche in Google Scholar PubMed PubMed Central
[17] Stahl-Pehe A, Lange K, Bächle C, Castillo K, Holl RW, Rosenbauer J. Mental health problems among adolescents with early-onset and long-duration type 1 diabetes and their association with quality of life: a population-based survey. PLoS One. 2014;9(3):e92473.10.1371/journal.pone.0092473Suche in Google Scholar PubMed PubMed Central
[18] Castellano-Guerrero A, Guerrero R, Relimpio F, Losada F, Mangas M, Pumar A, et al. Prevalence and predictors of depression and anxiety in adult patients with type 1 diabetes in tertiary care setting. Acta Diabetol. 2018;55:943–53.10.1007/s00592-018-1172-5Suche in Google Scholar PubMed
[19] Schram MT, Baan CA, Pouwer F. Depression and quality of life in patients with diabetes: a systematic review from the European Depression in Diabetes (EDID) research consortium. Curr Diabetes Rev. 2009;5(2):112–9.10.2174/157339909788166828Suche in Google Scholar PubMed PubMed Central
[20] Trotta D, Verrotti A, Salladini C, Chiarelli F. Diabetic neuropathy in children and adolescents. Pediatr Diabetes. 2004;5(1):44–57.10.1111/j.1399-543X.2004.00041.xSuche in Google Scholar PubMed
[21] Salvotelli L, Stoico V, Perrone F, Cacciatori V, Negri C, Brangani C, et al. Prevalence of neuropathy in type 2 diabetic patients and its association with other diabetes complications: the Verona Diabetic Foot Screening Program. J Diabetes Complications. 2015;29(8):1066–70.10.1016/j.jdiacomp.2015.06.014Suche in Google Scholar PubMed
[22] Kim SS, Won JC, Kwon HS, Kim CH, Lee JH, Park TS, et al. Prevalence and clinical implications of painful diabetic peripheral neuropathy in type 2 diabetes: results from a nationwide hospital-based study of diabetic neuropathy in Korea. Diabetes Res Clin Pract. 2014;103(3):522–9.10.1016/j.diabres.2013.12.003Suche in Google Scholar PubMed
[23] Louraki M, Katsalouli M, Kanaka-Gantenbein C, Kafassi N, Critselis E, Kallinikou D, et al. The prevalence of early subclinical somatic neuropathy in children and adolescents with Type 1 diabetes mellitus and its association with the persistence of autoantibodies to glutamic acid decarboxylase (GAD) and islet antigen-2 (IA-2). Diabetes Res Clin Pract. 2016;117:82–90.10.1016/j.diabres.2016.04.044Suche in Google Scholar PubMed
[24] Abbott CA, Malik RA, Ernest R, Kulkarni J, Boulton AJ. Prevalence and characteristics of painful diabetic neuropathy in a large community-based diabetes population in the UK. Diabetes Care. 2011:34:2220–4.10.2337/dc11-1108Suche in Google Scholar PubMed PubMed Central
[25] Hasani N, Khosrawi S, Hashemipour M, Haghighatiyan M, Javdan Z, Taheri MH, et al. Prevalence and related risk-factors of peripheral neuropathy in children with insulin-dependent diabetes mellitus. J Res Med Sci. 2013;18(2):132–6.Suche in Google Scholar
[26] Ghaemi N, Hasanabadi H, Ashrafzadeh F, Sarvari S, Rahimi H, Hashemian S. Peripheral neuropathy in children and adolescents with insulin-dependent diabetes mellitus. Iran J Child Neurol. 2018;12(2):83–90.Suche in Google Scholar
[27] Sobhani S, Asayesh H, Sharifi F, Djalalinia S, Baradaran HR, Arzaghi SM, et al. Prevalence of diabetic peripheral neuropathy in Iran: a systematic review and meta-analysis. J Diabetes Metab Disord. 2014;13(1):97.10.1186/s40200-014-0097-ySuche in Google Scholar PubMed PubMed Central
[28] Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med. 2009;151(4):264–9.10.7326/0003-4819-151-4-200908180-00135Suche in Google Scholar PubMed
[29] Von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP, et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. PLoS Med. 2007;4(10):e296.10.1097/EDE.0b013e3181577654Suche in Google Scholar PubMed
[30] Karamifar H, Mooadab M, Karamizadeh Z, Amirhakimi G. Evaluation of peripheral neuropathy in patients with type 1 diabetes mellitus by bedside scoring procedure. Iran J Pediatr. 2007;17(Suppl 1):54–60.Suche in Google Scholar
[31] Khorasani E. Prevalence of peripheral neuropathy and its related factors in diabetic children, Neishabour city, Iran. Int J Pediatr. 2018;6(12):8707–14.Suche in Google Scholar
[32] Olfatifar M, Karami M, Hosseini SM, shokri P. Prevalence of chronic complications and related risk factors of diabetes in patients referred to the diabetes center of Hamedan Province. Sci J Hamadan Nurs Midwifery Fac. 2017;25(2):69–74.10.21859/nmj-25029Suche in Google Scholar
[33] Kiani J, Moghimbeigi A, Azizkhani H, Kosarifard S. The prevalence and associated risk factors of peripheral diabetic neuropathy in Hamedan, Iran. Arch Iran Med. 2013;16(1):17–9.Suche in Google Scholar
[34] Khawaja N, Abu-Shennar J, Saleh M, Dahbour SS, Khader YS, Ajlouni KM. The prevalence and risk factors of peripheral neuropathy among patients with type 2 diabetes mellitus; the case of Jordan. Diabetol Metab Syndr. 2018;10(1):8.10.1186/s13098-018-0309-6Suche in Google Scholar PubMed PubMed Central
[35] Pop‐Busui R, Lu J, Lopes N, Jones TL. Prevalence of diabetic peripheral neuropathy and relation to glycemic control therapies at baseline in the BARI 2D cohort. J Peripher Nerv Syst. 2009;14(1):1–13.10.1111/j.1529-8027.2009.00200.xSuche in Google Scholar PubMed PubMed Central
[36] Bai J-W, Lovblom LE, Cardinez M, Weisman A, Farooqi MA, Halpern EM, et al. Neuropathy and presence of emotional distress and depression in longstanding diabetes: results from the Canadian study of longevity in type 1 diabetes. J Diabetes Complications. 2017;31(8):1318–24.10.1016/j.jdiacomp.2017.05.002Suche in Google Scholar PubMed
©2019 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Frontmatter
- Editorial
- Pharmacology for obesity: perspectives of history
- Reviews
- Trends and risk factors of adolescent opioid abuse/misuse: understanding the opioid epidemic among adolescents
- The prevalence of neuropathy among type 1 diabetic adolescents in Iran: a systematic review and meta-analysis
- Original Articles
- The relationship between spiritual health and health-promoting lifestyle among students
- Investigating the relationship between Islamic lifestyle and general health in adolescents
- Participation and attitudes towards gambling in Ghanaian youth: an exploratory analysis of risk and protective factors
- Effectiveness of acupressure on anxiety of children undergoing anesthesia
- Occupational agricultural injuries among the preadolescent workers of West Bengal, India
- Flourishing and academic engagement among adolescents with overweight and obesity
- Increased aggressive behavior among youth in the United States who have experienced multiple forms of victimization
- Knowledge and awareness of oral cancer and impact of pictorial warnings on the willingness to quit tobacco in young tobacco consumers in India
- The biopsychosocial condition of childhood cancer survivors in the transition towards adult care: a national survey from the joint pediatric and adult transition care group
- Is a smartphone application effective in improving physical activity among medical school students? Results from a quasi-experimental study
- Effect of education based on protection motivation theory on adolescents’ reproductive health self-care: a randomized controlled trial
- The range of normative surface skin temperature changes in adolescents: prospective multicenter study
- Women’s reproductive health needs assessment questionnaire: development and validation
- Factors influencing engagement in premarital sex among Vietnamese young adults: a qualitative study
- Dental treatment needs using a sociodental approach among south Indian youths: a cross-sectional study
- Will I, Wont I? Factors associated with self-reported prediction of future indulgence in intimate partner violence among adolescents in South India
- High-risk behaviors and demographic features: a cross-sectional study among Iranian adolescents
- Spiritual health: is it a determinant factor for preventing risky behaviors among university students?
- Adolescent’s psychological health in Iran
- The association between nutrition knowledge and adherence to a Mediterranean dietary pattern in Iranian female adolescents
- Socio-demographic differentials of cognitive development and nutrition among school children: evidence from the tribal areas of Jharkhand, India
- Parents to chronically ill adolescents have ambivalent views on confidential youth consultations – a mixed methods study
- Tooth wear patterns in subjects with class II division 1 and class II division 2 malocclusion
- Rate of weight gain as a predictor of readmission in adolescents with eating disorders
- Hydration status, total water intake and subjective feelings of adolescents living in a hot environment, during a typical school day
- Head and neck cancer awareness: a survey of young people in international communities
- The significant role of educational status in PKU patients: the beneficial effect of psychological support in depression
- The impact of arthritis on the educational and early work experiences of young people: a qualitative secondary analysis
- Short Communications
- The influences of stimulation mode and stimulus frequency on acoustic reflex latency (ARL) among young adults
- Improving recruitment and retention of adolescents and young adults with cancer in randomized controlled clinical trials
Artikel in diesem Heft
- Frontmatter
- Editorial
- Pharmacology for obesity: perspectives of history
- Reviews
- Trends and risk factors of adolescent opioid abuse/misuse: understanding the opioid epidemic among adolescents
- The prevalence of neuropathy among type 1 diabetic adolescents in Iran: a systematic review and meta-analysis
- Original Articles
- The relationship between spiritual health and health-promoting lifestyle among students
- Investigating the relationship between Islamic lifestyle and general health in adolescents
- Participation and attitudes towards gambling in Ghanaian youth: an exploratory analysis of risk and protective factors
- Effectiveness of acupressure on anxiety of children undergoing anesthesia
- Occupational agricultural injuries among the preadolescent workers of West Bengal, India
- Flourishing and academic engagement among adolescents with overweight and obesity
- Increased aggressive behavior among youth in the United States who have experienced multiple forms of victimization
- Knowledge and awareness of oral cancer and impact of pictorial warnings on the willingness to quit tobacco in young tobacco consumers in India
- The biopsychosocial condition of childhood cancer survivors in the transition towards adult care: a national survey from the joint pediatric and adult transition care group
- Is a smartphone application effective in improving physical activity among medical school students? Results from a quasi-experimental study
- Effect of education based on protection motivation theory on adolescents’ reproductive health self-care: a randomized controlled trial
- The range of normative surface skin temperature changes in adolescents: prospective multicenter study
- Women’s reproductive health needs assessment questionnaire: development and validation
- Factors influencing engagement in premarital sex among Vietnamese young adults: a qualitative study
- Dental treatment needs using a sociodental approach among south Indian youths: a cross-sectional study
- Will I, Wont I? Factors associated with self-reported prediction of future indulgence in intimate partner violence among adolescents in South India
- High-risk behaviors and demographic features: a cross-sectional study among Iranian adolescents
- Spiritual health: is it a determinant factor for preventing risky behaviors among university students?
- Adolescent’s psychological health in Iran
- The association between nutrition knowledge and adherence to a Mediterranean dietary pattern in Iranian female adolescents
- Socio-demographic differentials of cognitive development and nutrition among school children: evidence from the tribal areas of Jharkhand, India
- Parents to chronically ill adolescents have ambivalent views on confidential youth consultations – a mixed methods study
- Tooth wear patterns in subjects with class II division 1 and class II division 2 malocclusion
- Rate of weight gain as a predictor of readmission in adolescents with eating disorders
- Hydration status, total water intake and subjective feelings of adolescents living in a hot environment, during a typical school day
- Head and neck cancer awareness: a survey of young people in international communities
- The significant role of educational status in PKU patients: the beneficial effect of psychological support in depression
- The impact of arthritis on the educational and early work experiences of young people: a qualitative secondary analysis
- Short Communications
- The influences of stimulation mode and stimulus frequency on acoustic reflex latency (ARL) among young adults
- Improving recruitment and retention of adolescents and young adults with cancer in randomized controlled clinical trials