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Modulation of self-organizing circuits at deforming membranes by intracellular and extracellular factors

  • Anastasiia Sokolova ORCID logo and Milos Galic ORCID logo EMAIL logo
Published/Copyright: January 12, 2023
Biological Chemistry
From the journal Biological Chemistry Volume 404 Issue 5

Abstract

Mechanical forces exerted to the plasma membrane induce cell shape changes. These transient shape changes trigger, among others, enrichment of curvature-sensitive molecules at deforming membrane sites. Strikingly, some curvature-sensing molecules not only detect membrane deformation but can also alter the amplitude of forces that caused to shape changes in the first place. This dual ability of sensing and inducing membrane deformation leads to the formation of curvature-dependent self-organizing signaling circuits. How these cell-autonomous circuits are affected by auxiliary parameters from inside and outside of the cell has remained largely elusive. Here, we explore how such factors modulate self-organization at the micro-scale and its emerging properties at the macroscale.

Keywords: cytoskeletal forces; extracellular matrix; membrane curvature; membrane lipids; membrane mechanics; self-organization
Corresponding author: Milos Galic, Institute of Medical Physics and Biophysics, University of Münster, Robert-Koch-Straße 31, 48149 Münster, Germany; and ‘Cells in Motion’ Interfaculty Centre, University of Münster, Röntgenstraße 16, 48149 Münster, German, E-mail:

Funding source: Interdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Münster

Award Identifier / Grant number: IZKF Ga3/016/21

Funding source: Deutsche Forschungsgemeinschaft

Award Identifier / Grant number: CRC1348/A06

Award Identifier / Grant number: CRC944/P22

Award Identifier / Grant number: GA-2268-4/1

Acknowledgments

We would thank the members of the Galic group for critical feedback on the manuscript.

  1. Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: The authors acknowledge funding from the CIM-IMRS graduate school Münster (to A.S.), the Medical Faculty of the University of Münster (to MG: IZKF Ga3/016/21), and the German Research Council (to MG: CRC944/P22, CRC1348/A06, GA-2268-4/1).

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Received: 2022-09-26
Accepted: 2022-12-16
Published Online: 2023-01-12
Published in Print: 2023-04-25

© 2022 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Highlight: Physiology and Dynamics of Cellular Microcompartments
  3. Highlight: on the past and the future of cellular microcompartments
  4. Nuclear redox processes in land plant development and stress adaptation
  5. The readily retrievable pool of synaptic vesicles
  6. Loss of respiratory complex I subunit NDUFB10 affects complex I assembly and supercomplex formation
  7. Modulation of self-organizing circuits at deforming membranes by intracellular and extracellular factors
  8. Computational resolution in single molecule localization – impact of noise level and emitter density
  9. Setting up a data management infrastructure for bioimaging
  10. Molecular insights into endolysosomal microcompartment formation and maintenance
  11. The role of lysosomes in lipid homeostasis
  12. Membrane damage and repair: a thin line between life and death
  13. Neuronal stress granules as dynamic microcompartments: current concepts and open questions
  14. Molecular determinants of protein half-life in chloroplasts with focus on the Clp protease system
  15. Neprilysin 4: an essential peptidase with multifaceted physiological relevance
  16. Determinants of synergistic cell-cell interactions in bacteria
  17. Drosophila collagens in specialised extracellular matrices
https://doi.org/10.1515/hsz-2022-0290
Keywords for this article
cytoskeletal forces; extracellular matrix; membrane curvature; membrane lipids; membrane mechanics; self-organization

Articles in the same Issue

  1. Frontmatter
  2. Highlight: Physiology and Dynamics of Cellular Microcompartments
  3. Highlight: on the past and the future of cellular microcompartments
  4. Nuclear redox processes in land plant development and stress adaptation
  5. The readily retrievable pool of synaptic vesicles
  6. Loss of respiratory complex I subunit NDUFB10 affects complex I assembly and supercomplex formation
  7. Modulation of self-organizing circuits at deforming membranes by intracellular and extracellular factors
  8. Computational resolution in single molecule localization – impact of noise level and emitter density
  9. Setting up a data management infrastructure for bioimaging
  10. Molecular insights into endolysosomal microcompartment formation and maintenance
  11. The role of lysosomes in lipid homeostasis
  12. Membrane damage and repair: a thin line between life and death
  13. Neuronal stress granules as dynamic microcompartments: current concepts and open questions
  14. Molecular determinants of protein half-life in chloroplasts with focus on the Clp protease system
  15. Neprilysin 4: an essential peptidase with multifaceted physiological relevance
  16. Determinants of synergistic cell-cell interactions in bacteria
  17. Drosophila collagens in specialised extracellular matrices
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