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Neprilysin 4: an essential peptidase with multifaceted physiological relevance

  • Annika Buhr , Ronja Schiemann and Heiko Meyer ORCID logo EMAIL logo
Published/Copyright: January 19, 2023
Biological Chemistry
From the journal Biological Chemistry Volume 404 Issue 5

Abstract

Neprilysins are highly conserved ectoenzymes that hydrolyze and thus inactivate signaling peptides in the extracellular space. Herein, we focus on Neprilysin 4 from Drosophila melanogaster and evaluate the existing knowledge on the physiological relevance of the peptidase. Particular attention is paid to the role of the neprilysin in regulating feeding behavior and the expression of insulin-like peptides in the central nervous system. In addition, we assess the function of the peptidase in controlling the activity of the sarcoplasmic and endoplasmic reticulum Ca2+ ATPase in myocytes, as well as the underlying molecular mechanism in detail.

Keywords: Drosophila melanogaster ; heart function; insulin signaling; metalloendopeptidase; peptide signaling; SERCA
Corresponding author: Heiko Meyer, Department of Biology/Chemistry, Zoology and Developmental Biology Section, Osnabruck University, Barbarastrasse 11, D-49076 Osnabruck, Germany; and Center for Cellular Nanoanalytics (CellNanOs), Barbarastrasse 11, D-49076 Osnabruck, Germany, E-mail:

Funding source: Deutsche Forschungsgemeinschaft

Award Identifier / Grant number: SFB 944 - P21

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: This research was funded by the German Research Foundation (SFB 944: Physiology and Dynamics of Cellular Microcompartments, P21, HM), and by a stipend from the Hans Mühlenhoff Foundation (RS).

  3. Conflict of interest statement: The authors declare no conflicts of interest regarding this article.

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Received: 2022-09-22
Accepted: 2022-12-27
Published Online: 2023-01-19
Published in Print: 2023-04-25

© 2023 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

  1. Frontmatter
  2. Highlight: Physiology and Dynamics of Cellular Microcompartments
  3. Highlight: on the past and the future of cellular microcompartments
  4. Nuclear redox processes in land plant development and stress adaptation
  5. The readily retrievable pool of synaptic vesicles
  6. Loss of respiratory complex I subunit NDUFB10 affects complex I assembly and supercomplex formation
  7. Modulation of self-organizing circuits at deforming membranes by intracellular and extracellular factors
  8. Computational resolution in single molecule localization – impact of noise level and emitter density
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  14. Molecular determinants of protein half-life in chloroplasts with focus on the Clp protease system
  15. Neprilysin 4: an essential peptidase with multifaceted physiological relevance
  16. Determinants of synergistic cell-cell interactions in bacteria
  17. Drosophila collagens in specialised extracellular matrices
https://doi.org/10.1515/hsz-2022-0286
Keywords for this article
Drosophila melanogaster; heart function; insulin signaling; metalloendopeptidase; peptide signaling; SERCA

Articles in the same Issue

  1. Frontmatter
  2. Highlight: Physiology and Dynamics of Cellular Microcompartments
  3. Highlight: on the past and the future of cellular microcompartments
  4. Nuclear redox processes in land plant development and stress adaptation
  5. The readily retrievable pool of synaptic vesicles
  6. Loss of respiratory complex I subunit NDUFB10 affects complex I assembly and supercomplex formation
  7. Modulation of self-organizing circuits at deforming membranes by intracellular and extracellular factors
  8. Computational resolution in single molecule localization – impact of noise level and emitter density
  9. Setting up a data management infrastructure for bioimaging
  10. Molecular insights into endolysosomal microcompartment formation and maintenance
  11. The role of lysosomes in lipid homeostasis
  12. Membrane damage and repair: a thin line between life and death
  13. Neuronal stress granules as dynamic microcompartments: current concepts and open questions
  14. Molecular determinants of protein half-life in chloroplasts with focus on the Clp protease system
  15. Neprilysin 4: an essential peptidase with multifaceted physiological relevance
  16. Determinants of synergistic cell-cell interactions in bacteria
  17. Drosophila collagens in specialised extracellular matrices
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