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Caenorhabditis elegans as a model to study sphingolipid signaling

  • Xinzhu Deng and Richard Kolesnick EMAIL logo
Published/Copyright: February 3, 2015

Abstract

Sphingolipid signaling in Caenorhabditis elegans is vital for sensing environmental change and effecting appropriate cellular response. Many molecular components in sphingolipid intermediary metabolism are conserved throughout evolution. Here we review use of C. elegans as a model system for conducting sphingolipid-based scientific investigation, which has helped us better understand vital roles these remarkable lipids play in human metabolism and disease.


Corresponding author: Richard Kolesnick, Laboratory of Signal Transduction, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, ZRC 1805, New York, NY 10065, USA, e-mail:

Acknowledgments

We gratefully appreciate the assistance of Joerg Thomas Hannich and Howard Riezman in writing the section describing structural differences between C. elegans and mammalian sphingolipids.

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Received: 2014-12-5
Accepted: 2015-1-26
Published Online: 2015-2-3
Published in Print: 2015-6-1

©2015 by De Gruyter

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