Startseite Exploration of meteorin-like peptide (metrnl) predictors in type 2 diabetic patients: the potential role of irisin, and other biochemical parameters
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Exploration of meteorin-like peptide (metrnl) predictors in type 2 diabetic patients: the potential role of irisin, and other biochemical parameters

  • Yaser Khajebishak , Amir Hossein Faghfouri , Ali Soleimani , Sadra Madani und Laleh Payahoo EMAIL logo
Veröffentlicht/Copyright: 3. Oktober 2022
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Hormone Molecular Biology and Clinical Investigation
Aus der Zeitschrift Hormone Molecular Biology and Clinical Investigation Band 44 Heft 2

Abstract

Objectives

Meteorin-like peptide (Metrnl), the newly discovered adipokines involves in glucose and lipid metabolism and energy homeostasis. The aim of the present study was to explore the potential predictors of Metrnl by emphasizing the Irisin, glycemic indices, and lipid profile biomarkers in type 2 diabetic patients.

Methods

This cross-sectional study was carried out on 32 obese types 2 diabetic patients, 31 healthy obese, and 30 healthy normal weight people between August 2020 and March 2021. Serum Metrnl and Irisin, fasting blood glucose (FBS), fasting insulin (FI), fasting insulin (FI), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), HbA1c and eAG levels were measured in a standard manner. To assay insulin resistance and insulin sensitivity, the homeostatic model assessment insulin resistance (HOMA‐IR) and quantitative check index (QUICKI) model were used. Quantile regression analysis with the backward elimination method was used to explore predictors. The significant level was defined as p<0.05.

Results

Between variables entered into the model, only the group item showed to be the main predictor of Metrnl in type 2 diabetic patients. Besides, the serum level of Irisin was lower in diabetic patients, and a significant difference was detected between obese diabetic patients and the normal weight group (p=0.024).

Conclusions

Given the multi-causality of diabetes and also the possible therapeutic role of Metrnl in the management of type 2 diabetic patients’ abnormalities, designing future studies are needed to discover other predictors of Metrnl and the related mechanisms of Metrnl in the management of diabetes.

Keywords: Blood glucose; cholesterol; insulin; irisin; metrnl protein; triglycerides; type 2; diabetes mellitus
Corresponding author: Laleh Payahoo, Assistant Professor of Nutrition, Department of Nutrition and Food Sciences, Maragheh University of Medical Sciences, Maragheh, Iran, Phone: +984137276363, E-mail:

  1. Research funding: The regional ethics committee of the Maragheh University of Medical Sciences approved the protocol of the study with registered ethics number “IR.MARAGHEHPHC.REC.1398.029”.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Conflicts of interest: Authors declare that there is no conflict of interest.

  4. Informed consent: A written consent form was completed for each participant.

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Received: 2022-04-12
Accepted: 2022-08-21
Published Online: 2022-10-03

© 2022 Walter de Gruyter GmbH, Berlin/Boston

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https://doi.org/10.1515/hmbci-2022-0037
Schlagwörter für diesen Artikel
Blood glucose; cholesterol; insulin; irisin; metrnl protein; triglycerides; type 2; diabetes mellitus

Artikel in diesem Heft

  1. Frontmatter
  2. Letter to the Editor
  3. The role of gut microbiota in etiopathogenesis of long COVID syndrome
  4. Original Articles
  5. Risk factors and inflammatory markers in acute coronary syndrome-ST elevation myocardial infarction (STEMI)
  6. Association of pro-inflammatory cytokines, inflammatory proteins with atherosclerosis index in obese male subjects
  7. Exploration of meteorin-like peptide (metrnl) predictors in type 2 diabetic patients: the potential role of irisin, and other biochemical parameters
  8. Distinct urinary progesterone metabolite profiles during the luteal phase
  9. Promoter methylation levels of RASSF1 and ATIC genes are associated with lung cancer in Iranian patients
  10. Population status of selenium in Colombia and associated factors: a cross-sectional study
  11. Bambusa vulgaris leaves reverse mitochondria dysfunction in diabetic rats through modulation of mitochondria biogenic genes
  12. Increased expression of androgen receptor and PSA genes in LNCaP (prostate cancer) cell line due to high concentrations of EGCG, an active ingredient in green tea
  13. The effects of endurance exercise and metformin on memory impairment caused by diabetes
  14. Exercise modulation in inflammation and metabolic hormonal disorders of COVID-19 to decrease risk factors in coronary heart disease
  15. The effect of co-administration of artemisinin and N-acetyl cysteine on antioxidant status, spermatological parameters and histopathology of testis in adult male mice
  16. Case Report
  17. Unilateral ovarian agenesis with ipsilateral tubal presence – report of a case
  18. Review Articles
  19. Brown adipose tissue as an endocrine organ: updates on the emerging role of batokines
  20. Zuranolone and its role in treating major depressive disorder: a narrative review
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Heruntergeladen am 7.11.2025 von https://www.degruyterbrill.com/document/doi/10.1515/hmbci-2022-0037/pdf?lang=de
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