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Association of pro-inflammatory cytokines, inflammatory proteins with atherosclerosis index in obese male subjects

  • Farhad Alizadeh , Fariba Mirzaie Bavil , Rana Keyhanmanesh ORCID logo , Hajie Lotfi and Fariba Ghiasi EMAIL logo
Published/Copyright: January 3, 2023
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Hormone Molecular Biology and Clinical Investigation
From the journal Hormone Molecular Biology and Clinical Investigation Volume 44 Issue 2

Abstract

Objectives

Investigation the association of pro-inflammatory markers interleukin (IL)-1β and IL- 10 expression, serum levels of C-reactive protein (CRP), cyclooxygenase-2 (COX2), High-density lipoprotein (HDL), Apolipoprotein A1 (ApoA1), and ATP Binding Cassette Subfamily A Member 1 (ABCA1) inflammatory proteins with atherosclerosis index (homocysteine) in normal-weight and obese male subjects.

Methods

59 males including 30 obese (Body mass index (BMI) of ≥30 kg/m2) and 29 normal-weight (BMI of 18.5–24.9 kg/m2) were joined to this study. Plasma levels of IL-1β and IL-10 (pg/mL), CRP (pg/mL), COX-2 (ng/mL), APOA1 (mg/dL), ABCA1 (ng/mL), HDL, Cholesterol, and Triglyceride (TG) (mg/dL), and homocysteine (µmol/L) was measured. Association of these biomarkers with homocysteine was determined.

Results

Obese subjects had higher serum levels of IL10, IL1β, CRP, COX-2, TG, and cholesterol concentrations (all p<0.05 except IL-10 and cholesterol) and low levels of HDL, APOA1, and ABCA1 (non-significant differences) in comparison to normal-weight group. Homocysteine levels were high in obese men with no significant differences between the two groups. In obese subjects, homocysteine had a significant inverse correlation with APOA1, ABCA1, and HDL, and a strong and moderate positive correlation was found with CRP and TG levels, respectively.

Conclusions

High level of homocysteine and its correlation with inflammation proteins and markers in obese subjects appear to be contributed with atherosclerosis development.

Keywords: arthrosclerosis; homocysteine; inflammation cytokines; obese
Corresponding author: Dr. Fariba Ghiasi, Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; and Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Phone: +989143181498, E-mail:

Funding source: Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

Award Identifier / Grant number: 65834

  1. Research funding: This work was supported by Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran (65834).

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Declaring of the competing interest: We have no conflict of interest.

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Received: 2022-02-17
Accepted: 2022-07-19
Published Online: 2023-01-03

© 2022 Walter de Gruyter GmbH, Berlin/Boston

Articles in the same Issue

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  2. Letter to the Editor
  3. The role of gut microbiota in etiopathogenesis of long COVID syndrome
  4. Original Articles
  5. Risk factors and inflammatory markers in acute coronary syndrome-ST elevation myocardial infarction (STEMI)
  6. Association of pro-inflammatory cytokines, inflammatory proteins with atherosclerosis index in obese male subjects
  7. Exploration of meteorin-like peptide (metrnl) predictors in type 2 diabetic patients: the potential role of irisin, and other biochemical parameters
  8. Distinct urinary progesterone metabolite profiles during the luteal phase
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  11. Bambusa vulgaris leaves reverse mitochondria dysfunction in diabetic rats through modulation of mitochondria biogenic genes
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  13. The effects of endurance exercise and metformin on memory impairment caused by diabetes
  14. Exercise modulation in inflammation and metabolic hormonal disorders of COVID-19 to decrease risk factors in coronary heart disease
  15. The effect of co-administration of artemisinin and N-acetyl cysteine on antioxidant status, spermatological parameters and histopathology of testis in adult male mice
  16. Case Report
  17. Unilateral ovarian agenesis with ipsilateral tubal presence – report of a case
  18. Review Articles
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  20. Zuranolone and its role in treating major depressive disorder: a narrative review
https://doi.org/10.1515/hmbci-2022-0022
Keywords for this article
arthrosclerosis; homocysteine; inflammation cytokines; obese

Articles in the same Issue

  1. Frontmatter
  2. Letter to the Editor
  3. The role of gut microbiota in etiopathogenesis of long COVID syndrome
  4. Original Articles
  5. Risk factors and inflammatory markers in acute coronary syndrome-ST elevation myocardial infarction (STEMI)
  6. Association of pro-inflammatory cytokines, inflammatory proteins with atherosclerosis index in obese male subjects
  7. Exploration of meteorin-like peptide (metrnl) predictors in type 2 diabetic patients: the potential role of irisin, and other biochemical parameters
  8. Distinct urinary progesterone metabolite profiles during the luteal phase
  9. Promoter methylation levels of RASSF1 and ATIC genes are associated with lung cancer in Iranian patients
  10. Population status of selenium in Colombia and associated factors: a cross-sectional study
  11. Bambusa vulgaris leaves reverse mitochondria dysfunction in diabetic rats through modulation of mitochondria biogenic genes
  12. Increased expression of androgen receptor and PSA genes in LNCaP (prostate cancer) cell line due to high concentrations of EGCG, an active ingredient in green tea
  13. The effects of endurance exercise and metformin on memory impairment caused by diabetes
  14. Exercise modulation in inflammation and metabolic hormonal disorders of COVID-19 to decrease risk factors in coronary heart disease
  15. The effect of co-administration of artemisinin and N-acetyl cysteine on antioxidant status, spermatological parameters and histopathology of testis in adult male mice
  16. Case Report
  17. Unilateral ovarian agenesis with ipsilateral tubal presence – report of a case
  18. Review Articles
  19. Brown adipose tissue as an endocrine organ: updates on the emerging role of batokines
  20. Zuranolone and its role in treating major depressive disorder: a narrative review
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