Association between vitamin D deficiency and prevalence of metabolic syndrome in female population: a systematic review

Nazila Fathi Maroufi; Pourya Pezeshgi; Zohreh Mortezania; Pirouz Pourmohammad; Reyhaneh Eftekhari; Mahmood Moradzadeh; Vahid Vahedian; Mohammad Nouri

doi:10.1515/hmbci-2020-0033

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Article

Association between vitamin D deficiency and prevalence of metabolic syndrome in female population: a systematic review

Nazila Fathi Maroufi , Pourya Pezeshgi , Zohreh Mortezania , Pirouz Pourmohammad , Reyhaneh Eftekhari , Mahmood Moradzadeh , Vahid Vahedian and Mohammad Nouri

Published/Copyright: September 28, 2020

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From the journal Hormone Molecular Biology and Clinical Investigation Volume 41 Issue 4

Abstract

Background

The increasing prevalence of metabolic syndrome (MS) especially in female population, has become a major problem in health care systems. In this regards, it is necessary to identify the risk factors. Vitamin D deficiency is now proposed as one of the possible risk factors for metabolic syndrome, we investigated the relationship between vitamin D status and MS in female.

Methods

We searched observational studies with keywords Vitamin D, metabolic syndrome, metabolic syndrome X, insulin-resistance syndrome, metabolic cardiovascular syndrome and Reaven Syndrome X and female in pubmed, scopus, science direct, cochrane, web of science, google scholar and SID databases, regardless of publication time. Two hundred ninety five studies were found, and finally only 12 articles were selected according to exclusion and inclusion criteria.

Results

In nine studies that reported the prevalence of MS, the prevalence of MS among women with vitamin D deficiency was higher than female with normal vitamin D (34.5 vs. 30.2%). The prevalence of abdominal obesity, high blood pressure, high TG and HDL deficiency is higher in women with vitamin D deficiency. Also, the mean waist circumference, blood pressure, fast blood sugar (FBS), TG and BMI were higher. The most incident factor was high blood pressure (61.4 vs. 56.5%) and the lowest prevalence is associated with high FBS (32.2 vs. 33.5% in the other group).

Conclusion

The prevalence of MS is significantly associated with vitamin D deficiency, and among related factors, HDL, TG and blood pressure are statistically associated with vitamin D status.

Keywords: female; metabolic syndrome; vitamin D

Corresponding authors: Mohammad Nouri, Stem Cell and Regenerative Medicine Institute, Tabriz University of Medical Sciences, Tabriz, Islamic Republic of Iran, Phone: +989144054268, E-mail: nourimd@yahoo.com; and Vahid Vahedian, Department of Experimental Biomedicine, Dr.Vahid Vahedian Medical Diagnostic Laboratory Gorgan, Tehran, Islamic Republic of Iran; and Department of Medical Laboratory Sciences, Faculty of Medicine, Islamic Azad University (IAU), Sari, Islamic Republic of Iran, E-mail: vahid.vahedian4545@gmail.com

Nazila Fathi Maroufi andPourya Pezeshgi are contributed equally to this article.

Acknowledgment

We would like to thank Dr. Hallajzadeh for his extensive training and assistance in searching for resources as well as extracting data.

Research funding: None declared.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Conflict of interest: None declared.
Informed consent: Not applicable.
Ethical approval: Not applicable.

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Received: 2020-05-25

Accepted: 2020-08-24

Published Online: 2020-09-28

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Articles in the same Issue

https://doi.org/10.1515/hmbci-2020-0033

Keywords for this article

female; metabolic syndrome; vitamin D