Associations of endothelial biomarkers, nitric oxide metabolites and endothelin, with blood pressure and coronary lesions depend on cardiovascular risk and sex to mark endothelial dysfunction on the SCORE scale
-
Nadezhda G. Gumanova
,
Alexander U. Gorshkov
Abstract
Objectives
Endothelial dysfunction contributes to the onset and progression of cardiovascular diseases. However, direct associations of vasoactive mediators with cardiovascular risk are poorly understood.
Methods
We have determined associations of circulating levels of stable metabolites of nitric oxide, nitrate and nitrite (NOx), endothelin-1, and the endothelin-1/NOx ratio with blood pressure in 177 asymptomatic subjects without signs of coronary atherosclerosis; associations with blood pressure and with presence of coronary lesions were also evaluated in 457 patients suspected to have coronary heart disease with or without coronary lesions confirmed by coronary angiography. All participants were on a low nitrate diet 24 h prior to blood sampling.
Results
In men, NOx levels were inversely correlated with blood pressure similar to women with low (0–4%) European Systematic Coronary Risk Estimation (SCORE). However, the correlation was not significant in women with high SCORE (5–8%). High systolic blood pressure over 140 mm Hg was negatively associated with NOx levels in asymptomatic men (p=0.05) but not in women. This association is disrupted in male and female patients with coronary atherosclerosis. In male patients, NOx (p=0.05), endothelin (p=0.01), and the endothelin/NOx ratio (p=0.04) were associated with presence of coronary lesions.
Conclusions
Thus, elevated cardiovascular risk according to SCORE over 4% in asymptomatic women, but not in men, is associated with a shift in markers of endothelial dysfunction. Presence of coronary lesions in patients is associated with significant changes in circulating levels of markers of endothelial dysfunction in men but not in women.
Funding source: Russian Foundation for Basic Research
Award Identifier / Grant number: No 17-04-00157
Research funding: The study was supported by the Russian Foundation for Basic Research grant No 17-04-00157.
Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: The authors declare no conflict of interests.
Informed consent: All participants gave their written informed consent to participate in the study and to grant access to their personal data.
Ethical approval: The study complied with all the relevant national regulations and institutional policies. Study protocols have been approved by the Ethics Committee of NRCPM according to the guidelines of the Helsinki Declaration and WHO.
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© 2020 Walter de Gruyter GmbH, Berlin/Boston
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Artikel in diesem Heft
- Letter to the Editor
- Evidence-based medicine is a valuable tool for a successful decision-making on risk-reducing bilateral mastectomy
- Original Articles
- Melatonin inhibits high glucose-induced ox-LDL/LDL expression and apoptosis in human umbilical endothelial cells
- Effects of metformin and insulin therapy regimens on postpartum oral glucose tolerance test results in pregnant women with gestational diabetes mellitus: a comparative study
- Association of IL-33 gene rs16924159 polymorphism and recurrent pregnancy loss in Iranian Azeri women
- Greater effects of high- compared with moderate-intensity interval training on thyroid hormones in overweight/obese adolescent girls
- Effect of Artemisia absinthium ethanolic extract on oxidative stress markers and the TLR4, S100A4, Bax and Bcl-2 genes expression in the kidney of STZ-induced diabetic rats
- Associations of endothelial biomarkers, nitric oxide metabolites and endothelin, with blood pressure and coronary lesions depend on cardiovascular risk and sex to mark endothelial dysfunction on the SCORE scale
- Association of nitric oxide synthase 3 gene rs1799983 G/T polymorphism with idiopathic asthenozoospermia in Iranian Azeri males: a case-control study
- Adiponectin and leptin levels in normal weight women with polycystic ovary syndrome
- Review Articles
- Association between vitamin D deficiency and prevalence of metabolic syndrome in female population: a systematic review
- Vitamin D and sleep duration: Is there a bidirectional relationship?
- Challenges of post-traumatic stress disorder (PTSD) in Iraq: biochemical network and methodologies. A brief review
- Female urine incontinence: vaginal erbium laser (VEL) effectiveness and safety
- Breast cancer risk factors in Iran: a systematic review & meta-analysis
- Effects of melatonin supplementation on oxidative stress: a systematic review and meta-analysis of randomized controlled trials
