Adiponectin and leptin levels in normal weight women with polycystic ovary syndrome
-
Murat Gözüküçük
,
Aslı Yarcı Gürsoy
Abstract
Objectives
Since polycystic ovarian syndrome (PCOS) is prevalent in reproductive women with obesity and insulin resistance, adipocytokines are often accused and investigated for pathophysiology. The aim of this study was to evaluate the adiponectin and leptin levels in normal-weight women with PCOS.
Methods
Forty women with PCOS and 40 age and body mass index (BMI) matched controls were included in the study. Adiponectin and leptin levels in addition to other biochemical parameters were measured.
Results
Leptin levels were statistically significantly higher in the study group compared to the control group (6.53 ± 2.670 vs 3.37 ± 2.002 ng/mL, p < 0.001 respectively). Although Adiponectin levels were lower in the study group compared to the control group (28.89 ± 16.124 μg/mL vs 31.05 ± 20.507, p = 0.714 respectively) the difference did not reach statistical significance. Leptin levels were positively correlated with fasting glucose, fasting insulin, free testosterone levels and homeostatic model assessment of insulin resistance (HOMA-IR) values. Adiponectin levels were negatively correlated with BMI.
Conclusions
Adiponectin and leptin have been suggested to play a crucial role in the pathogenesis of PCOS. Different adipocytokine levels in the normal weight PCOS group compared to age and BMI matched controls support the idea that adipose tissue in this group of women has some distinctive features not only in high BMI subgroup but also in normal weight subgroup.
Research funding: Authors state no funding involved.
Competing of interests: Authors state no conflict of interest.
Informed consent: Informed consent was obtained from all the included women.
Ethical approval: The study protocol was approved by the institutional review board.
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© 2020 Walter de Gruyter GmbH, Berlin/Boston
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Articles in the same Issue
- Letter to the Editor
- Evidence-based medicine is a valuable tool for a successful decision-making on risk-reducing bilateral mastectomy
- Original Articles
- Melatonin inhibits high glucose-induced ox-LDL/LDL expression and apoptosis in human umbilical endothelial cells
- Effects of metformin and insulin therapy regimens on postpartum oral glucose tolerance test results in pregnant women with gestational diabetes mellitus: a comparative study
- Association of IL-33 gene rs16924159 polymorphism and recurrent pregnancy loss in Iranian Azeri women
- Greater effects of high- compared with moderate-intensity interval training on thyroid hormones in overweight/obese adolescent girls
- Effect of Artemisia absinthium ethanolic extract on oxidative stress markers and the TLR4, S100A4, Bax and Bcl-2 genes expression in the kidney of STZ-induced diabetic rats
- Associations of endothelial biomarkers, nitric oxide metabolites and endothelin, with blood pressure and coronary lesions depend on cardiovascular risk and sex to mark endothelial dysfunction on the SCORE scale
- Association of nitric oxide synthase 3 gene rs1799983 G/T polymorphism with idiopathic asthenozoospermia in Iranian Azeri males: a case-control study
- Adiponectin and leptin levels in normal weight women with polycystic ovary syndrome
- Review Articles
- Association between vitamin D deficiency and prevalence of metabolic syndrome in female population: a systematic review
- Vitamin D and sleep duration: Is there a bidirectional relationship?
- Challenges of post-traumatic stress disorder (PTSD) in Iraq: biochemical network and methodologies. A brief review
- Female urine incontinence: vaginal erbium laser (VEL) effectiveness and safety
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