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Effects of melatonin supplementation on oxidative stress: a systematic review and meta-analysis of randomized controlled trials

  • Parivash Ghorbaninejad , Fatemeh Sheikhhossein , Farhang Djafari , Aliyu Jibril Tijani , Saba Mohammadpour und Sakineh Shab-Bidar EMAIL logo
Veröffentlicht/Copyright: 13. November 2020
Hormone Molecular Biology and Clinical Investigation
Aus der Zeitschrift Hormone Molecular Biology and Clinical Investigation Band 41 Heft 4

Abstract

Objectives

Previous studies showed that melatonin supplementation may suppress oxidative stress, however, the results have not been consistent. So, we conducted this meta-analysis to assess the precise relationship between melatonin supplementation and oxidative stress.

Methods

PubMed and Scopus were searched for randomized controlled trials that investigated the effect of melatonin supplementation on oxidative stress up to March 2020. Heterogeneity was assessed by Cochran’s Q test and I-square (I2) statistic. Data were pooled using the random effect model and standardized mean difference (SMD) was considered as the summary effect size. Also, standard methods were used for assessment of sensitivity analysis and publication bias.

Results

We included 15 related articles and our findings indicated that melatonin supplementation significantly increased total antioxidant capacity (TAC) level (SMD: 1.03, 95% CI: 0.24, 1.81, p=0.011) and reduced protein carbonyl (PCO) (SMD: −1.78, 95% CI: −2.97, −0.58, p=0.004) and malondialdehyde (MDA) levels (SMD: −0.94, 95% CI: −1.48, −0.40, p=0.001). Additionally, there was considerable effect on TAC level by using ≥20 mg/d melatonin and in people under 35 years old. MDA level also decreased using dosage of below 20 mg/d and in people ≥35 years old.

Conclusions

The present study showed a promising effect of melatonin administration for reducing MDA, PCO, and increasing TAC levels. However, further studies especially with more attention to PCO level assessment are needed to confirm the findings of the present study in larger samples on different populations.

Keywords: melatonin; meta-analysis; oxidative stress; supplementation; systematic review
Corresponding author: Sakineh Shab-Bidar, Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran, Phone: +98 21 88955975, Fax: +98 21 88974462, E-mail:

  1. Research funding: Authors state no funding involved.

  2. Author contributions: PG and SSb contributed to conception/design of the research; PG, FS, AT and SM contributed to acquisition, analysis, or interpretation of the data; PG, FS and FD drafted the manuscript; SSb critically revised the manuscript; and SSb agree to be fully accountable for ensuring the integrity and accuracy of the work. All authors read and approved the final manuscript.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent is not applicable.

  5. Ethical approval: The conducted research is not related to either human or animals use.

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Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/hmbci-2020-0030).

Received: 2020-05-15
Accepted: 2020-10-26
Published Online: 2020-11-13

© 2020 Walter de Gruyter GmbH, Berlin/Boston

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  3. Original Articles
  4. Melatonin inhibits high glucose-induced ox-LDL/LDL expression and apoptosis in human umbilical endothelial cells
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  15. Challenges of post-traumatic stress disorder (PTSD) in Iraq: biochemical network and methodologies. A brief review
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https://doi.org/10.1515/hmbci-2020-0030
Schlagwörter für diesen Artikel
melatonin; meta-analysis; oxidative stress; supplementation; systematic review

Artikel in diesem Heft

  1. Letter to the Editor
  2. Evidence-based medicine is a valuable tool for a successful decision-making on risk-reducing bilateral mastectomy
  3. Original Articles
  4. Melatonin inhibits high glucose-induced ox-LDL/LDL expression and apoptosis in human umbilical endothelial cells
  5. Effects of metformin and insulin therapy regimens on postpartum oral glucose tolerance test results in pregnant women with gestational diabetes mellitus: a comparative study
  6. Association of IL-33 gene rs16924159 polymorphism and recurrent pregnancy loss in Iranian Azeri women
  7. Greater effects of high- compared with moderate-intensity interval training on thyroid hormones in overweight/obese adolescent girls
  8. Effect of Artemisia absinthium ethanolic extract on oxidative stress markers and the TLR4, S100A4, Bax and Bcl-2 genes expression in the kidney of STZ-induced diabetic rats
  9. Associations of endothelial biomarkers, nitric oxide metabolites and endothelin, with blood pressure and coronary lesions depend on cardiovascular risk and sex to mark endothelial dysfunction on the SCORE scale
  10. Association of nitric oxide synthase 3 gene rs1799983 G/T polymorphism with idiopathic asthenozoospermia in Iranian Azeri males: a case-control study
  11. Adiponectin and leptin levels in normal weight women with polycystic ovary syndrome
  12. Review Articles
  13. Association between vitamin D deficiency and prevalence of metabolic syndrome in female population: a systematic review
  14. Vitamin D and sleep duration: Is there a bidirectional relationship?
  15. Challenges of post-traumatic stress disorder (PTSD) in Iraq: biochemical network and methodologies. A brief review
  16. Female urine incontinence: vaginal erbium laser (VEL) effectiveness and safety
  17. Breast cancer risk factors in Iran: a systematic review & meta-analysis
  18. Effects of melatonin supplementation on oxidative stress: a systematic review and meta-analysis of randomized controlled trials
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