Ovarian and uterine leiomyosarcoma: which one is the primary?
-
Mohamad Nasir Shafiee
,
Reena Rahayu Md Zain
Abstract
Uterine leiomyosarcoma (LMS) is rare but primary ovarian LMS is even rarer constituting less than 0.1% of all gynecologic disorders. Neither histologic features nor immunohistochemistry could be utilized to distinguish between uterine or ovarian origin. We illustrate a clinical case of metastatic LMS to the ovary in a woman with underlying uterine fibroid presenting with anemia with heavy menses.
Author statement
Research funding: None declared.
Conflict of interest: None declared.
Informed consent: Not applicable.
Ethical approval: Not applicable.
References
[1] Tirumani SH, Deaver P, Shinagare AB, Tirumani H, Hornick JL, George S, et al. Metastatic pattern of uterine leiomyosarcoma: retrospective analysis of the predictors and outcome in 113 patients. J Gynecol Oncol. 2014;25:306–12.10.3802/jgo.2014.25.4.306Suche in Google Scholar PubMed PubMed Central
[2] Bouie SM, Cracchiolo B, Heller D. Epithelioid leiomyosarcoma of the ovary. Gynecol Oncol. 2005;97:697–9.10.1016/j.ygyno.2005.02.008Suche in Google Scholar PubMed
[3] Anderson B, Turner DA, Benda J. Ovarian sarcoma. Gynecol Oncol. 1987;26:183–92.10.1016/0090-8258(87)90272-1Suche in Google Scholar PubMed
[4] Dandapani M, Seagle B-LL, Abdullah A, Hatfield B, Samuelson R, Shahabi S. Metastatic uterine Leiomyosarcoma involving bilateral ovarian Stroma without capsular involvement implies a local route of Hematogenous dissemination. Case Rep Obstet Gynecol. 2015;2015.10.1155/2015/950373Suche in Google Scholar PubMed PubMed Central
[5] Lakhman Y, Veeraraghavan H, Chaim J, Feier D, Goldman DA, Moskowitz CS, et al. Differentiation of uterine leiomyosarcoma from atypical leiomyoma: diagnostic accuracy of qualitative MR imaging features and feasibility of texture analysis. Eur Radiol. 2017;27:2903–15.10.1007/s00330-016-4623-9Suche in Google Scholar PubMed PubMed Central
[6] Chiang S, Oliva E. Recent developments in uterine mesenchymal neoplasms. Histopathology. 2013;62:124–37.10.1111/his.12048Suche in Google Scholar PubMed
[7] Hensley ML, Barrette BA, Baumann K, Gaffney D, Hamilton AL, Kim J-W, et al. GCIG Consensus review: uterine and ovarian leiomyosarcomas. Int J Gynecol Cancer: J Int Gynecol Cancer Soc. 2014;24(9 Suppl 3):S61.10.1097/IGC.0000000000000261Suche in Google Scholar PubMed PubMed Central
[8] Roberts ME, Aynardi JT, Chu CS. Uterine leiomyosarcoma: a review of the literature and update on management options. Gynecol Oncol. 2018;151(3):562–72.10.1016/j.ygyno.2018.09.010Suche in Google Scholar PubMed
[9] Pautier P, Floquet A, Gladieff L, Bompas E, Ray-Coquard I, Piperno-Neumann S, et al. A randomized clinical trial of adjuvant chemotherapy with doxorubicin, ifosfamide, and cisplatin followed by radiotherapy versus radiotherapy alone in patients with localized uterine sarcomas (SARCGYN study). A study of the French Sarcoma Group. Ann Oncol. 2012;24:1099–104.10.1093/annonc/mds545Suche in Google Scholar PubMed
[10] van der Graaf WT, Blay J-Y, Chawla SP, Kim D-W, Bui-Nguyen B, Casali PG, et al. Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial. The Lancet. 2012;379:1879–86.10.1016/S0140-6736(12)60651-5Suche in Google Scholar PubMed
© 2019 Walter de Gruyter GmbH, Berlin/Boston
Artikel in diesem Heft
- Letters to the Editor
- Androgen-driven COVID-19 infection – is testosterone an enemy or a friend?
- Tumor necrosis factor-α gene-1031T/C promoter polymorphism and endometriosis
- Original Articles
- Serum FGF-21 and FGF-23 in association with gestational diabetes: a longitudinal case-control study
- Neutrophil and monocyte ratios to high-density lipoprotein-cholesterol and adiponectin as biomarkers of nascent metabolic syndrome
- Predicting long-term cardiovascular outcomes of patients with acute myocardial infarction using soluble ST2
- Anti-inflammatory activity of emu oil-based nanofibrous scaffold through downregulation of IL-1, IL-6, and TNF-α pro-inflammatory cytokines
- A comparative study of the antidiabetic effect of two training protocols in streptozotocin-nicotinamide diabetic rats
- Gonadotrophins modulate cell death-related genes expression in human endometrium
- Exploring the activity of the enzyme 11β-hydroxylase in the polycystic ovary syndrome
- The effects of follicle-stimulating hormone receptor (FSHR) -29 and Ser680Asn polymorphisms in IVF/ICSI
- Diagnostic value of the candidate microRNAs in thyroid fine-needle aspiration biopsy (FNAB) samples
- Investigation of the role of β-TrCP in growth hormone transduction defect (GHTD)
- High-intensity interval training with long duration intervals is more effective than short duration intervals for improving glycolytic capacity in the rats’ gastrocnemius muscle
- The effects of circuit resistance training on plasma progranulin level, insulin resistance and body composition in obese men
- Sexual motivation: problem solved and new problems introduced
- Case Reports
- Ovarian and uterine leiomyosarcoma: which one is the primary?
- Uterine-conserving approach in ruptured intramyometrial ectopic pregnancy
Artikel in diesem Heft
- Letters to the Editor
- Androgen-driven COVID-19 infection – is testosterone an enemy or a friend?
- Tumor necrosis factor-α gene-1031T/C promoter polymorphism and endometriosis
- Original Articles
- Serum FGF-21 and FGF-23 in association with gestational diabetes: a longitudinal case-control study
- Neutrophil and monocyte ratios to high-density lipoprotein-cholesterol and adiponectin as biomarkers of nascent metabolic syndrome
- Predicting long-term cardiovascular outcomes of patients with acute myocardial infarction using soluble ST2
- Anti-inflammatory activity of emu oil-based nanofibrous scaffold through downregulation of IL-1, IL-6, and TNF-α pro-inflammatory cytokines
- A comparative study of the antidiabetic effect of two training protocols in streptozotocin-nicotinamide diabetic rats
- Gonadotrophins modulate cell death-related genes expression in human endometrium
- Exploring the activity of the enzyme 11β-hydroxylase in the polycystic ovary syndrome
- The effects of follicle-stimulating hormone receptor (FSHR) -29 and Ser680Asn polymorphisms in IVF/ICSI
- Diagnostic value of the candidate microRNAs in thyroid fine-needle aspiration biopsy (FNAB) samples
- Investigation of the role of β-TrCP in growth hormone transduction defect (GHTD)
- High-intensity interval training with long duration intervals is more effective than short duration intervals for improving glycolytic capacity in the rats’ gastrocnemius muscle
- The effects of circuit resistance training on plasma progranulin level, insulin resistance and body composition in obese men
- Sexual motivation: problem solved and new problems introduced
- Case Reports
- Ovarian and uterine leiomyosarcoma: which one is the primary?
- Uterine-conserving approach in ruptured intramyometrial ectopic pregnancy
