Startseite Neutrophil and monocyte ratios to high-density lipoprotein-cholesterol and adiponectin as biomarkers of nascent metabolic syndrome
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Neutrophil and monocyte ratios to high-density lipoprotein-cholesterol and adiponectin as biomarkers of nascent metabolic syndrome

  • Ishwarlal Jialal EMAIL logo , Ganesh Jialal , Beverley Adams-Huet und Neeraj Ramakrishnan
Veröffentlicht/Copyright: 13. März 2020
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Abstract

Background

Metabolic syndrome (MetS) continues to be a significant problem globally, affecting nearly 35% of adults in the USA. Whilst there is no ideal biomarker that captures this disorder, high sensitivity C-reactive protein (hsCRP) appears to be most widely accepted. We examined the ratios between neutrophils (PMNs) and monocytes to high-density lipoprotein (HDL)-cholesterol and adiponectin, two anti-inflammatory proteins, in patients with nascent MetS without the confounding of diabetes, atherosclerotic cardiovascular diseases (ASCVD), smoking or lipid therapy to determine if they were also valid biomarkers of MetS.

Materials and methods

Patients with nascent MetS (n = 58) and matched controls (n = 44) were recruited from Sacramento County. Fasting blood samples were obtained for complete blood counts, basic metabolic panel, lipid profile, insulin and adiponectin. Ratios of PMNs and monocytes to HDL-C and adiponectin were calculated and compared statistically.

Results

The PMN:HDL-C, monocyte:HDL-C, PMN:adiponectin and monocyte:adiponectin ratios were significantly increased in patients with MetS and increased with increasing severity of MetS. Receiver operating characteristic (ROC) curve analysis showed that both the PMN:HDL-C and monocyte:HDL-C areas under the curve (AUCs) significantly added to the CRP AUC. Also both the ratios correlated with cardio-metabolic features of MetS, hsCRP and insulin resistance.

Conclusions

Our data indicates that ratios of neutrophils and monocytes to HDL-C are significantly increased in patients with nascent MetS and both ratios appear to be better predictors of MetS than hsCRP alone. These important preliminary findings need to be confirmed in large prospective databases.

Acknowledgments

The authors thank the American Diabetes Association.

Author statement

  1. Research funding: This study was funded in part from a grant from the American Diabetes Association to I. Jialal.

  2. Conflict of interest: The authors have no financial or other conflicts of interest to disclose.

  3. Informed consent: All study participants signed an informed consent form obtained and approved by the Institutional Review Board at the University of California Davis.

  4. Ethical approval: The research related to human use complied with all the relevant national regulations and institutional policies and was performed in accordance with the tenets of the Helsinki Declaration and has been approved by the Institutional Review Board at the University of California Davis.

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Received: 2019-11-20
Accepted: 2020-02-01
Published Online: 2020-03-13

© 2020 Walter de Gruyter GmbH, Berlin/Boston

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