Predicting long-term cardiovascular outcomes of patients with acute myocardial infarction using soluble ST2
-
Mustafa Umut Somuncu
, Belma Kalayci
, Ahmet Avci , Tunahan Akgun , Huseyin Karakurt , Ali Riza Demir , Yalcin Avci und Murat Can
Abstract
Background
The increase in soluble suppression of tumorigenicity 2 (sST2) both in the diagnosis and prognosis of heart failure is well established; however, existing data regarding sST2 values as the prognostic marker after myocardial infarction (MI) are limited and have been conflicting. This study aimed to assess the clinical significance of sST2 in predicting 1-year adverse cardiovascular (CV) events in MI patients.
Materials and methods
In this prospective study, 380 MI patients were included. Participants were grouped into low sST2 (n = 264, mean age: 60.0 ± 12.1 years) and high sST2 groups (n = 116, mean age: 60.5 ± 11.6 years), and all study populations were followed up for major adverse cardiovascular events (MACE) which are composed of CV mortality, target vessel revascularization (TVR), non-fatal reinfarction, stroke and heart failure.
Results
During a 12-month follow-up, 68 (17.8%) patients had MACE. CV mortality and heart failure were significantly higher in the high sST2 group compared to the low sST2 group (15.5% vs. 4.9%, p = 0.001 and 8.6% vs. 3.4% p = 0.032, respectively). Multivariate Cox regression analysis concluded that high serum sST2 independently predicted 1-year CV mortality [hazard ratio (HR) 2.263, 95% confidence interval (CI) 1.124–4.557, p = 0.022)]. Besides, older age, Killip class >1, left anterior descending (LAD) as the culprit artery and lower systolic blood pressure were the other independent risk factors for 1-year CV mortality.
Conclusions
High sST2 levels are an important predictor of MACE, including CV mortality and heart failure in a 1-year follow-up period in MI patients.
Author statement
Research funding: No funding was received for this research.
Conflict of interest: None declared.
Informed consent: Informed consent forms were obtained from all patients.
Ethical approval: Approval was obtained from the local Ethics Committee. The study was designed following the rules of the Helsinki Declaration.
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Artikel in diesem Heft
- Letters to the Editor
- Androgen-driven COVID-19 infection – is testosterone an enemy or a friend?
- Tumor necrosis factor-α gene-1031T/C promoter polymorphism and endometriosis
- Original Articles
- Serum FGF-21 and FGF-23 in association with gestational diabetes: a longitudinal case-control study
- Neutrophil and monocyte ratios to high-density lipoprotein-cholesterol and adiponectin as biomarkers of nascent metabolic syndrome
- Predicting long-term cardiovascular outcomes of patients with acute myocardial infarction using soluble ST2
- Anti-inflammatory activity of emu oil-based nanofibrous scaffold through downregulation of IL-1, IL-6, and TNF-α pro-inflammatory cytokines
- A comparative study of the antidiabetic effect of two training protocols in streptozotocin-nicotinamide diabetic rats
- Gonadotrophins modulate cell death-related genes expression in human endometrium
- Exploring the activity of the enzyme 11β-hydroxylase in the polycystic ovary syndrome
- The effects of follicle-stimulating hormone receptor (FSHR) -29 and Ser680Asn polymorphisms in IVF/ICSI
- Diagnostic value of the candidate microRNAs in thyroid fine-needle aspiration biopsy (FNAB) samples
- Investigation of the role of β-TrCP in growth hormone transduction defect (GHTD)
- High-intensity interval training with long duration intervals is more effective than short duration intervals for improving glycolytic capacity in the rats’ gastrocnemius muscle
- The effects of circuit resistance training on plasma progranulin level, insulin resistance and body composition in obese men
- Sexual motivation: problem solved and new problems introduced
- Case Reports
- Ovarian and uterine leiomyosarcoma: which one is the primary?
- Uterine-conserving approach in ruptured intramyometrial ectopic pregnancy