Abstract
Lactic acid is recognised as a biocompatible medium for the chemoselective synthesis of the 1,2-disubstituted benzimidazole scaffold via a direct one-pot cyclocondensation of o-phenylenediamine with aldehydes. Various 1,2-disubstituted benzimidazole derivatives were successfully synthesised with high selectivity with good to excellent yields without any additional catalyst or additive. Most products could be isolated by a simple filtration after completion of the reactions. Satisfactory results were also obtained from multi-gram scale reactions.
Acknowledgements
This work received financial support from the Department of Education of Jiangxi Provinceand Key Laboratory of Functional Small Organic Molecules, Ministry of Education (no. GJJ13214, KLFS-KF-201229).
References
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© 2016 Institute of Chemistry, Slovak Academy of Sciences
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- Original Paper
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- Original Paper
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- Original Paper
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