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Changes of serum adiponectin and soluble intercellular adhesion molecule-1 concentrations after smoking cessation
-
Jaw-Shiun Tsai
und
Ching-Yu Chen
Veröffentlicht/Copyright:
9. Januar 2012
Abstract
Background: This study aims to investigate the effect of increased serum adiponectin concentration during smoking cessation on soluble intercellular adhesion molecule-1 (sICAM-1) concentration.
Methods: One hundred and sixty-six eligible smokers were assessed at baseline and were followed up at the 1st, 5th, and 9th weeks after smoking cessation. Demographic data, body weight and blood pressure of these participants were obtained; serum glucose biochemical data, sICAM-1 and adiponectin concentrations were measured. Repeated measures analysis paired t-tests and generalized estimating equations for balanced repeated measures were used for statistical analyses.
Results: Forty-one individuals completed the 2-month smoking cessation program. The mean cigarette consumption dramatically decreased (p<0.0001) and the cotinine concentration also decreased significantly (p<0.0001) among the quitters. Serum adiponectin concentration significantly increased (p=0.0186) and sICAM-1 significantly decreased (p<0.0001) in quitters after smoking cessation. The elevation of serum adiponectin concentration significantly correlated with lowering of sICAM-1 (p=0.0001) concentration. Body weight changes at the end of 2-month smoking cessation was inversely correlated with adiponectin increment from baseline (p=0.0003).
Conclusions: An increase in serum adiponectin concentration is an independent factor correlated with lowering of sICAM-1 concentration during smoking cessation.
Keywords: adiponectin; body weight; cardiovascular disease; intercellular adhesion molecule-1; smoking cessation
Received: 2011-4-5
Accepted: 2011-12-13
Published Online: 2012-01-09
Published in Print: 2012-06-01
©2012 by Walter de Gruyter Berlin Boston
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Schlagwörter für diesen Artikel
adiponectin;
body weight;
cardiovascular disease;
intercellular adhesion molecule-1;
smoking cessation
Artikel in diesem Heft
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