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The evolutionary pathway of the staphylococcal cassette chromosome element

  • Adéla Indráková , Ivana Mašlaňová EMAIL logo , Viera Kováčová , Jiří Doškař und Roman Pantůček
Veröffentlicht/Copyright: 25. Dezember 2016
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Biologia
Aus der Zeitschrift Biologia Band 71 Heft 11

Abstract

The staphylococcal cassette chromosome (SCC) element can carry resistance genes to antibiotics, disinfectants, and heavy metals, contributing to the survival of strains in the environment and causing difficulties in the treatment of staphylococcal infections. Methicillin resistance in staphylococci, which is of particular clinical significance, is encoded by staphylococcal cassette chromosome mec (SCCmec). Despite the importance of the SCC element and description of multiple nucleotide sequences, the information about its origin and evolution is still scarce. Here, we present a phylogenetic analysis of SCC elements that is unique in the use of whole SCC sequences. A phylogenetic tree for a noteworthy number of 81 SCC elements based on global sequence alignment was constructed. The SCC clustering did not reflect the genetic relationships of bacteria containing the SCC elements, but was done according to type, determined by the combination of mec gene complex class and ccr gene complex type. The results emphasise the horizontal gene transfer as a means of spread of SCC elements in bacterial strains. Overall, this study contributes to the understanding of SCC emergence, evolution, and dissemination.

Keywords: Staphylococcus; methicillin-resistant Staphylococcus aureus (MRSA); staphylococcal cassette chromosome; evolution; mobile genetic elements

Acknowledgements

This work was supported by a grant from the Czech Science Foundation (GP13-05069P). Access to computing and storage facilities owned by parties and projects contributing to the National Grid Infrastructure MetaCentrum, provided under the programme “Projects of Large Infrastructure for Research, Development, and Innovations” (LM2010005), is greatly appreciated. We thank Eva Kodytková for her valuable help with this manuscript.

Abbreviations

ACME

arginine catabolic mobile element

CA-MRSA

community-acquired methicillin-resistant Staphylococcus aureus

CC

clonal complex

ccr

chromosome cassette recombinase

CoNS

coagulase-negative staphylococci

HA-MRSA

hospital-acquired methicillin-resistant Staphylococcus aureus

HGT

horizontal gene transfer

LCB

locally collinear block

MGE

mobile genetic element

MLST

multilocus sequence typing

MRSA

methicillin-resistant Staphylococcus aureus

MSSA

methicillin-susceptible Staphylococcus aureus

SCC

staphylococcal cassette chromosome

SCCmec

staphylococcal cassette chromosome mec

ST

sequence type

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Received: 2016-8-5
Accepted: 2016-11-19
Published Online: 2016-12-25
Published in Print: 2016-11-1

© 2016 Institute of Molecular Biology, Slovak Academy of Sciences

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  19. Zoology
  20. Comparison of Macroheterocera assemblages of four forests in the Bereg Plain (Hungary, Ukraine)
  21. Zoology
  22. Late flooding combined with warm autumn – potential possibility for prolongation of transmission of mosquito-borne diseases
  23. Zoology
  24. Temperature and precipitation effects on breeding productivity of some passerines – a multivariate analysis of constant effort mist-netting data
  25. Cellular and Molecular Biology
  26. The direct action of hyaluronic acid on human U-937 and HL-60 cells – modification of native and model membranes
https://doi.org/10.1515/biolog-2016-0156
Schlagwörter für diesen Artikel
Staphylococcus; methicillin-resistant Staphylococcus aureus (MRSA); staphylococcal cassette chromosome; evolution; mobile genetic elements

Artikel in diesem Heft

  1. Cellular and Molecular Biology
  2. The evolutionary pathway of the staphylococcal cassette chromosome element
  3. Cellular and Molecular Biology
  4. Detection of the antibacterial effect of Chaetomium cochliodes Palliser CCM F-232 based on agar plugs and unprocessed fungal substances from cultivation media
  5. Botany
  6. Identification and molecular characterization of one novel 1Sl-encoded s-type low molecular weight glutenin B-subunit from 1Sl(1B) substitution line of wheat variety Chinese Spring (Triticum aestivum)
  7. Botany
  8. Bioinformatic analysis of Arabidopsis reverse transcriptases with a zinc-finger domain
  9. Botany
  10. Distinct expression patterns of the GDP dissociation inhibitor protein gene (OsRhoGDI2) from Oryza sativa during development and abiotic stresses
  11. Botany
  12. An application of genetics-chemicals constituents to the relatedness of three Euphorbia species
  13. Zoology
  14. Centipede (Chilopoda) richness, diversity and community structure in the forest-steppe nature reserve “Bielinek” on the Odra River (NW Poland, Central Europe)
  15. Zoology
  16. Genetic differentiating Aphis fabae and Aphis craccivora (Hemiptera: Sternorranycha: Aphididae) populations in Egypt using mitochondrial COI
  17. Zoology
  18. A faunistic study on Carabidae and Scarabaeidae in alfalfa fields from Central Greece
  19. Zoology
  20. Comparison of Macroheterocera assemblages of four forests in the Bereg Plain (Hungary, Ukraine)
  21. Zoology
  22. Late flooding combined with warm autumn – potential possibility for prolongation of transmission of mosquito-borne diseases
  23. Zoology
  24. Temperature and precipitation effects on breeding productivity of some passerines – a multivariate analysis of constant effort mist-netting data
  25. Cellular and Molecular Biology
  26. The direct action of hyaluronic acid on human U-937 and HL-60 cells – modification of native and model membranes
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