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No effect of MDR1 C3435T polymorphism on oral pharmacokinetics of telmisartan in 19 healthy Chinese male subjects
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Xin Guo
Veröffentlicht/Copyright:
10. Dezember 2008
Abstract
Background: Considerable interindividual differences in both drug response and pharmacokinetics of telmisartan have been identified. This study was designed to investigate the influence of MDR1 C3435T polymorphism on pharmacokinetics of telmisartan after a single oral dose in healthy Chinese volunteers.
Methods: A total of 61 unrelated male volunteers were genotyped for MDR1 C3435T polymorphism by using the polymerase chain reaction-restriction fragment length polymorphism method. Six 3435CC homozygotes, eight 3435CT heterozygotes, and five 3435TT homozygotes were randomly selected and received a single oral dose of 40 mg telmisartan. Plasma concentrations of telmisartan were determined by the high performance liquid chromatography-mass spectrometry method up to 48 h after telmisartan administration.
Results: Interindividual variation for tmax, Cmax, t1/2, AUC0–48, AUC0–∞, and clearance (CL) for telmisartan was approximately 6-, 33-, 16-, 17-, 20-, and 20-fold, respectively. Cmax (p=0.010), t1/2 (p=0.029) and CL (p=0.010) of telmisartan were not normally distributed. MDR1 3435TT homozygotes seemed to show increases in Cmax, tmax, t1/2, AUC0–48, and AUC0–∞. However, no significant differences in Cmax, tmax, t1/2, AUC0–48, AUC0–∞, and CL among MDR1 C3435T genotypes were observed.
Conclusions: MDR1 C3435T polymorphism does not affect oral pharmacokinetics of telmisartan.
Clin Chem Lab Med 2009;47:38–43.
Keywords: Chinese; multidrug resistance 1 gene (MDR1); pharmacokinetics; single nucleotide polymorphism; telmisartan
Received: 2008-5-19
Accepted: 2008 -7-11
Published Online: 2008-12-10
Published Online: 2008-12-10
Published in Print: 2009-01-01
©2009 by Walter de Gruyter Berlin New York
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Schlagwörter für diesen Artikel
Chinese;
multidrug resistance 1 gene (MDR1);
pharmacokinetics;
single nucleotide polymorphism;
telmisartan
Artikel in diesem Heft
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- HIV-GB virus C co-infection: an overview
- Genetics and Molecular Diagnostics
- Relationships between C-reactive protein concentration and genotype in healthy volunteers
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- Functional polymorphisms in ACE and CYP11B2 genes and atrial fibrillation in patients with hypertensive heart disease
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- A novel large deletion and three polymorphisms in the FECH gene associated with erythropoietic protoporphyria
- Aging and endothelial progenitor cell telomere length in healthy men
- Gln222Arg (A2317G) polymorphism in the deoxyribonuclease I gene exhibits ethnic and functional differences
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- Relationships of serum haptoglobin concentration with HbA1c and glycated albumin concentrations in Japanese type 2 diabetic patients
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- Current practices in antinuclear antibody testing: results from the Belgian External Quality Assessment Scheme
- Verification of the analytical range of a new reagent for full-range C-reactive protein determination
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