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Prospective of Ras signaling in stem cells
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Koushik Chakrabarty
Veröffentlicht/Copyright:
6. Juni 2008
Abstract
The Ras signaling pathway plays a predominant role during development and controls diverse biological process in all eukaryotic cells. It is a member of the large family of GTPases proteins that binds and hydrolyzes GTP. Ras is a lipid-anchored protein on the intracellular membrane compartments, and cycles between inactive GDP-bound and the signaling competent GTP-bound conformation. Studies have demonstrated Ras to be a central regulator in signal transduction pathways responding to diverse extracellular and intracellular stimuli. Much progress has been made towards delineating specific genes involved in the process of pluripotency and differentiation of stem cells. Here, we discuss recent aspects of Ras signaling pathways in mediating stem cell properties.
Keywords: development; differentiation; proliferation; self-renewal; survival; therapeutic; tyrosine receptor kinase
Published Online: 2008-06-06
Published in Print: 2008-07-01
©2008 by Walter de Gruyter Berlin New York
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Artikel in diesem Heft
- Guest Editorial
- Highlight: Self-renewal signaling in stem cells
- Commentary
- Commentary: Highlight on stem cell research
- Highlight: Self-Renewal Signaling in Stem Cells
- Prospective of Ras signaling in stem cells
- Prowling wolves in sheep's clothing: the search for tumor stem cells
- Lineage development of hematopoietic stem and progenitor cells
- Plasticity after allogeneic hematopoietic stem cell transplantation
- Adult progenitor cells in vascular remodeling during atherosclerosis
- Oct4 expression revisited: potential pitfalls for data misinterpretation in stem cell research
- Generation of transducible versions of transcription factors Oct4 and Sox2
- Cytokine combinations differentially influence the SDF-1α-dependent migratory activity of cultivated murine hematopoietic stem and progenitor cells
- Bone marrow-derived mesenchymal stem cell transplantation does not improve quality of muscle reinnervation or recovery of motor function after facial nerve transection in rats
- In vitro differentiation of reprogrammed murine somatic cells into hepatic precursor cells
- The WNT receptor FZD7 contributes to self-renewal signaling of human embryonic stem cells
- Genes and Nucleic Acids
- Elimination of hop latent viroid upon developmental activation of pollen nucleases
- Protein Structure and Function
- Solution structure of Phl p 3, a major allergen from timothy grass pollen
- A hypoallergenic hybrid molecule with increased immunogenicity consisting of derivatives of the major grass pollen allergens, Phl p 2 and Phl p 6
- Cell Biology and Signaling
- Epigallocatechin gallate inhibits endothelial exocytosis
- Proteolysis
- Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cells
- Reconstitution of human azurocidin catalytic triad and proteolytic activity by site-directed mutagenesis
Schlagwörter für diesen Artikel
development;
differentiation;
proliferation;
self-renewal;
survival;
therapeutic;
tyrosine receptor kinase
Artikel in diesem Heft
- Guest Editorial
- Highlight: Self-renewal signaling in stem cells
- Commentary
- Commentary: Highlight on stem cell research
- Highlight: Self-Renewal Signaling in Stem Cells
- Prospective of Ras signaling in stem cells
- Prowling wolves in sheep's clothing: the search for tumor stem cells
- Lineage development of hematopoietic stem and progenitor cells
- Plasticity after allogeneic hematopoietic stem cell transplantation
- Adult progenitor cells in vascular remodeling during atherosclerosis
- Oct4 expression revisited: potential pitfalls for data misinterpretation in stem cell research
- Generation of transducible versions of transcription factors Oct4 and Sox2
- Cytokine combinations differentially influence the SDF-1α-dependent migratory activity of cultivated murine hematopoietic stem and progenitor cells
- Bone marrow-derived mesenchymal stem cell transplantation does not improve quality of muscle reinnervation or recovery of motor function after facial nerve transection in rats
- In vitro differentiation of reprogrammed murine somatic cells into hepatic precursor cells
- The WNT receptor FZD7 contributes to self-renewal signaling of human embryonic stem cells
- Genes and Nucleic Acids
- Elimination of hop latent viroid upon developmental activation of pollen nucleases
- Protein Structure and Function
- Solution structure of Phl p 3, a major allergen from timothy grass pollen
- A hypoallergenic hybrid molecule with increased immunogenicity consisting of derivatives of the major grass pollen allergens, Phl p 2 and Phl p 6
- Cell Biology and Signaling
- Epigallocatechin gallate inhibits endothelial exocytosis
- Proteolysis
- Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cells
- Reconstitution of human azurocidin catalytic triad and proteolytic activity by site-directed mutagenesis
