Plasticity after allogeneic hematopoietic stem cell transplantation
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Abstract
The postulated almost unlimited potential of transplanted hematopoietic stem cells (HSCs) to transdifferentiate into cell types that do not belong to the hematopoietic system denotes a complete paradigm shift of the hierarchical hemopoietic tree. In several studies during the last few years, donor cells have been identified in almost all recipient tissues after allogeneic HSC transplantation (HSCT), supporting the theory that any failing organ could be accessible to regenerative cell therapy. However, the putative potential ability of the stem cells to cross beyond lineage barriers has been questioned by other studies which suggest that hematopoietic cells might fuse with non-hematopoietic cells and mimic the appearance of transdifferentiation. Proof that HSCs have preserved the capacity to transdifferentiate into other cell types remains to be demonstrated. In this review, we focus mainly on clinical studies addressing plasticity in humans who underwent allogeneic HSCT. We summarize the published data on non-hematopoietic chimerism, donor cell contribution to tissue repair, the controversies related to the methods used to detect donor-derived non-hematopoietic cells and the functional impact of this phenomenon in diverse specific target tissues and organs.
©2008 by Walter de Gruyter Berlin New York
Articles in the same Issue
- Guest Editorial
- Highlight: Self-renewal signaling in stem cells
- Commentary
- Commentary: Highlight on stem cell research
- Highlight: Self-Renewal Signaling in Stem Cells
- Prospective of Ras signaling in stem cells
- Prowling wolves in sheep's clothing: the search for tumor stem cells
- Lineage development of hematopoietic stem and progenitor cells
- Plasticity after allogeneic hematopoietic stem cell transplantation
- Adult progenitor cells in vascular remodeling during atherosclerosis
- Oct4 expression revisited: potential pitfalls for data misinterpretation in stem cell research
- Generation of transducible versions of transcription factors Oct4 and Sox2
- Cytokine combinations differentially influence the SDF-1α-dependent migratory activity of cultivated murine hematopoietic stem and progenitor cells
- Bone marrow-derived mesenchymal stem cell transplantation does not improve quality of muscle reinnervation or recovery of motor function after facial nerve transection in rats
- In vitro differentiation of reprogrammed murine somatic cells into hepatic precursor cells
- The WNT receptor FZD7 contributes to self-renewal signaling of human embryonic stem cells
- Genes and Nucleic Acids
- Elimination of hop latent viroid upon developmental activation of pollen nucleases
- Protein Structure and Function
- Solution structure of Phl p 3, a major allergen from timothy grass pollen
- A hypoallergenic hybrid molecule with increased immunogenicity consisting of derivatives of the major grass pollen allergens, Phl p 2 and Phl p 6
- Cell Biology and Signaling
- Epigallocatechin gallate inhibits endothelial exocytosis
- Proteolysis
- Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cells
- Reconstitution of human azurocidin catalytic triad and proteolytic activity by site-directed mutagenesis
Articles in the same Issue
- Guest Editorial
- Highlight: Self-renewal signaling in stem cells
- Commentary
- Commentary: Highlight on stem cell research
- Highlight: Self-Renewal Signaling in Stem Cells
- Prospective of Ras signaling in stem cells
- Prowling wolves in sheep's clothing: the search for tumor stem cells
- Lineage development of hematopoietic stem and progenitor cells
- Plasticity after allogeneic hematopoietic stem cell transplantation
- Adult progenitor cells in vascular remodeling during atherosclerosis
- Oct4 expression revisited: potential pitfalls for data misinterpretation in stem cell research
- Generation of transducible versions of transcription factors Oct4 and Sox2
- Cytokine combinations differentially influence the SDF-1α-dependent migratory activity of cultivated murine hematopoietic stem and progenitor cells
- Bone marrow-derived mesenchymal stem cell transplantation does not improve quality of muscle reinnervation or recovery of motor function after facial nerve transection in rats
- In vitro differentiation of reprogrammed murine somatic cells into hepatic precursor cells
- The WNT receptor FZD7 contributes to self-renewal signaling of human embryonic stem cells
- Genes and Nucleic Acids
- Elimination of hop latent viroid upon developmental activation of pollen nucleases
- Protein Structure and Function
- Solution structure of Phl p 3, a major allergen from timothy grass pollen
- A hypoallergenic hybrid molecule with increased immunogenicity consisting of derivatives of the major grass pollen allergens, Phl p 2 and Phl p 6
- Cell Biology and Signaling
- Epigallocatechin gallate inhibits endothelial exocytosis
- Proteolysis
- Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cells
- Reconstitution of human azurocidin catalytic triad and proteolytic activity by site-directed mutagenesis
