Lineage development of hematopoietic stem and progenitor cells
-
Abstract
Hematopoietic stem cells have the potential to develop into multipotent and different lineage-restricted progenitor cells that subsequently generate all mature blood cell types. The classical model of hematopoietic lineage commitment proposes a first restriction point at which all multipotent hematopoietic progenitor cells become committed either to the lymphoid or to the myeloid development, respectively. Recently, this model has been challenged by the identification of murine as well as human hematopoietic progenitor cells with lymphoid differentiation capabilities that give rise to a restricted subset of the myeloid lineages. As the classical model does not include cells with such capacities, these findings suggest the existence of alternative developmental pathways that demand the existence of additional branches in the classical hematopoietic tree. Together with some phenotypic criteria that characterize different subsets of multipotent and lineage-restricted progenitor cells, we summarize these recent findings here.
©2008 by Walter de Gruyter Berlin New York
Articles in the same Issue
- Guest Editorial
- Highlight: Self-renewal signaling in stem cells
- Commentary
- Commentary: Highlight on stem cell research
- Highlight: Self-Renewal Signaling in Stem Cells
- Prospective of Ras signaling in stem cells
- Prowling wolves in sheep's clothing: the search for tumor stem cells
- Lineage development of hematopoietic stem and progenitor cells
- Plasticity after allogeneic hematopoietic stem cell transplantation
- Adult progenitor cells in vascular remodeling during atherosclerosis
- Oct4 expression revisited: potential pitfalls for data misinterpretation in stem cell research
- Generation of transducible versions of transcription factors Oct4 and Sox2
- Cytokine combinations differentially influence the SDF-1α-dependent migratory activity of cultivated murine hematopoietic stem and progenitor cells
- Bone marrow-derived mesenchymal stem cell transplantation does not improve quality of muscle reinnervation or recovery of motor function after facial nerve transection in rats
- In vitro differentiation of reprogrammed murine somatic cells into hepatic precursor cells
- The WNT receptor FZD7 contributes to self-renewal signaling of human embryonic stem cells
- Genes and Nucleic Acids
- Elimination of hop latent viroid upon developmental activation of pollen nucleases
- Protein Structure and Function
- Solution structure of Phl p 3, a major allergen from timothy grass pollen
- A hypoallergenic hybrid molecule with increased immunogenicity consisting of derivatives of the major grass pollen allergens, Phl p 2 and Phl p 6
- Cell Biology and Signaling
- Epigallocatechin gallate inhibits endothelial exocytosis
- Proteolysis
- Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cells
- Reconstitution of human azurocidin catalytic triad and proteolytic activity by site-directed mutagenesis
Articles in the same Issue
- Guest Editorial
- Highlight: Self-renewal signaling in stem cells
- Commentary
- Commentary: Highlight on stem cell research
- Highlight: Self-Renewal Signaling in Stem Cells
- Prospective of Ras signaling in stem cells
- Prowling wolves in sheep's clothing: the search for tumor stem cells
- Lineage development of hematopoietic stem and progenitor cells
- Plasticity after allogeneic hematopoietic stem cell transplantation
- Adult progenitor cells in vascular remodeling during atherosclerosis
- Oct4 expression revisited: potential pitfalls for data misinterpretation in stem cell research
- Generation of transducible versions of transcription factors Oct4 and Sox2
- Cytokine combinations differentially influence the SDF-1α-dependent migratory activity of cultivated murine hematopoietic stem and progenitor cells
- Bone marrow-derived mesenchymal stem cell transplantation does not improve quality of muscle reinnervation or recovery of motor function after facial nerve transection in rats
- In vitro differentiation of reprogrammed murine somatic cells into hepatic precursor cells
- The WNT receptor FZD7 contributes to self-renewal signaling of human embryonic stem cells
- Genes and Nucleic Acids
- Elimination of hop latent viroid upon developmental activation of pollen nucleases
- Protein Structure and Function
- Solution structure of Phl p 3, a major allergen from timothy grass pollen
- A hypoallergenic hybrid molecule with increased immunogenicity consisting of derivatives of the major grass pollen allergens, Phl p 2 and Phl p 6
- Cell Biology and Signaling
- Epigallocatechin gallate inhibits endothelial exocytosis
- Proteolysis
- Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cells
- Reconstitution of human azurocidin catalytic triad and proteolytic activity by site-directed mutagenesis
