Startseite Comparative proteomic analysis of neoplastic and non-neoplastic germ cell tissue
Artikel
Lizenziert
Nicht lizenziert Erfordert eine Authentifizierung

Comparative proteomic analysis of neoplastic and non-neoplastic germ cell tissue

  • Uwe Zimmermann , Heike Junker , Fabian Krämer , Stefan Balabanov , Britta Kleist , Winfried Kammer , Alfred Nordheim und Reinhard Walther
Veröffentlicht/Copyright: 11. April 2006
Biological Chemistry
Aus der Zeitschrift Band 387 Heft 4

Abstract

A comparative proteomic analysis of neoplastic versus non-neoplastic seminoma identified glutathione S-transferase M3 as a differentially expressed protein. This expression difference could also be observed at the mRNA level, implying neoplasm-associated alterations in transcriptional or post-transcriptional mechanisms.

:

Corresponding author

References

Balabanov, S., Zimmermann, U., Protzel, C., Scharf, C., and Walther, R. (2001). Tumour related enzyme alterations in clear cell type of human renal cell carcinoma identified by two-dimensional gel electrophoresis. Eur. J. Biochem.268, 5977–5980.10.1046/j.0014-2956.2001.02546.xSuche in Google Scholar

Bradford, M.M. (1976). A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye-binding. Anal. Biochem.282, 248–254.10.1016/0003-2697(76)90527-3Suche in Google Scholar

Campbell, E., Takahashi, Y., Abramovitz, M., Peretz, M., and Listowsky, I. (1990). A distinct human testis and brain mu-class glutathione S-transferase. Molecular cloning and characterization of a form present even in individuals lacking hepatic type mu isoenzymes. J. Biol. Chem.265, 9188–9193.Suche in Google Scholar

Eckert, W.A. and Kartenbeck, J. (1997). Färbung von Proteinen in Polyacrylamidgelen. In: Proteine: Standardmethoden der Molekular- und Zellbiologie (Berlin, Germany: Springer), pp. 123–126.Suche in Google Scholar

Geisler, S.A., Olshan, A.F., Cai, J., Weissler, M., Smith, J., and Bell, D. (2005). Glutathione S-transferase polymorphisms and survival from head and neck cancer. Head Neck27, 232–242.10.1002/hed.20141Suche in Google Scholar

Hashibe, M., Brennan, P., Strange, R.C., Bhisey, R., Cascorbi, I., Lazarus, P., Oude Ophuis, M.B., Benhamou, S., Foulkes, W.D., Katoh, T., et al. (2003). Meta and pooled analyses of GSTM1, GSTT1, GSTP1 and Cyp1A1 genotypes and risk of head and neck cancer. Cancer Epidemiol. Biomarkers Prev.12, 1509–1517.Suche in Google Scholar

Hussey, A.J. and Hayes, J.D. (1993). Human mu-class glutathione S-transferases present in liver, skeletal muscle and testicular tissue. Biochim. Biophys. Acta1203, 131–141.10.1016/0167-4838(93)90047-USuche in Google Scholar

Inskip, A., Elexperu-Camiruaga, J., Buxton, N., Dias, P., and MacIntosh, J. (1995). Identification of polymorphism at the glutathione S-transferase GSTM3 locus: evidence for linkage with GSTM1*A. Biochem. J.312, 713–716.10.1042/bj3120713Suche in Google Scholar

Institoris, E., Eid, H., Bodrogi, I., and Bak, M. (1998). Differential expression of glutathione S-transferases in germ cell tumors of human testes. Anticancer Res.18, 1727–1731.Suche in Google Scholar

Lifschitz-Mercer, B., Elliot, D.J., Issakov, J., Leider-Trejo, L., Schreiber, L., Misonzhnik, F., Eisenthal, A., and Maymon, B.B. (2002). Localization of a specific germ cell marker, DAZL 1, in testicular germ cell neoplasias. Virchow's Arch.440, 387–391.10.1007/s004280100528Suche in Google Scholar

Pearson, W.R., Vorachek, W.R., Xu, S., Berger, R., Hart, I., Vannais, D., and Patterson, D. (1993). Identification of class-mu glutathione S-transferase genes GSTM1GSTM5 on human chromosome 1p13. Am. J. Hum. Genet.53, 220–233.Suche in Google Scholar

Perkins, D.N., Pappin, D.J., Creasy, D.M., and Cottrell, J.S. (1999). Probability-based protein identification by searching sequence databases using mass spectrometry. Electrophoresis20, 3551–3567.10.1002/(SICI)1522-2683(19991201)20:18<3551::AID-ELPS3551>3.0.CO;2-2Suche in Google Scholar

Sarto, C., Frutiger, S., Cappellano, F., Sanchez, J.C., Doro, G., Cantanzaro, F., Hughes, G.J., Hochstrasser, D.F., and Mocarelli, P. (1999). Modified expression of plasma glutathione peroxidase and manganese superoxide dismutase in human renal cell carcinoma. Electrophoresis20, 3458–3466.10.1002/(SICI)1522-2683(19991101)20:17<3458::AID-ELPS3458>3.0.CO;2-5Suche in Google Scholar

Sarto, C., Vallsecchi, C., and Mocarelli, P. (2002). Renal cell carcinoma: handling and treatment. Proteomics2, 1627–1629.10.1002/1615-9861(200211)2:11<1627::AID-PROT1627>3.0.CO;2-KSuche in Google Scholar

Shevchenko, A., Wilm, M., Vorm, O., and Mann, M. (1996). Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels. Anal. Chem.68, 850–858.10.1021/ac950914hSuche in Google Scholar

Shevchenko, A., Chernusshevich, I., Ens, W., Standing, K.G., Thomson, B., Wilm, M., and Mann, M. (1997). Rapid ‘de novo’ peptide sequencing by a combination of nanoelectrospray, isotopic labeling and a quadrupole/time-of-flight mass spectrometer. Rapid Commun. Mass Spectrom.11, 1015–1024.10.1002/(SICI)1097-0231(19970615)11:9<1015::AID-RCM958>3.0.CO;2-HSuche in Google Scholar

Tetlow, N., Robinson, A., Mantle, T., and Board, P. (2004). Polymorphism of human mu class glutathione transferases. Pharmacogenetics14, 359–368.10.1097/00008571-200406000-00005Suche in Google Scholar

Tezel, G., Nagasaka, T., Shimono, Y., and Takahashi, M. (2002). Differential expression of RET finger protein in testicular germ cell tumors. Pathol. Int.52, 623–627.10.1046/j.1440-1827.2002.01401.xSuche in Google Scholar

Thomas, G.M., Sturgeon, J.F., Allison, R., Jewett, M., Goldberg, S., Sugar, L., Rideout, D., Gospodarowicz, M.K., and Duncan, W. (1989). Surveillance of stage I seminoma post orchiectomy. J. Urol.142, 313–316.10.1016/S0022-5347(17)38742-6Suche in Google Scholar

Yang, G., Shu, X.O., Ruan, Z.X., Cai, Q.Y., Jin, F., Gao, Y.T., and Zheng, W. (2005). Genetic polymorphisms in glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) and survival after chemotherapy for invasive breast carcinoma. Cancer103, 52–58.10.1002/cncr.20729Suche in Google Scholar

Published Online: 2006-04-11
Published in Print: 2006-04-01

©2006 by Walter de Gruyter Berlin New York

Artikel in diesem Heft

  1. Highlight: chronic oxidative stress and cancer
  2. Risk factors and mechanisms of hepatocarcinogenesis with special emphasis on alcohol and oxidative stress
  3. Does Helicobacter pylori cause gastric cancer via oxidative stress?
  4. Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis
  5. Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids
  6. Concomitant suppression of hyperlipidemia and intestinal polyp formation by increasing lipoprotein lipase activity in Apc-deficient mice
  7. Cancer-preventive anti-oxidants that attenuate free radical generation by inflammatory cells
  8. Evidence for attenuated cellular 8-oxo-7,8-dihydro-2′-deoxyguanosine removal in cancer patients
  9. The roles of ATP in the dynamics of the actin filaments of the cytoskeleton
  10. Chiral distinction between the enantiomers of bicyclic alcohols by UDP-glucuronosyltransferases 2B7 and 2B17
  11. A structural model of 20S immunoproteasomes: effect of LMP2 codon 60 polymorphism on expression, activity, intracellular localisation and insight into the regulatory mechanisms
  12. Role of the kinin B1 receptor in insulin homeostasis and pancreatic islet function
  13. Comparative proteomic analysis of neoplastic and non-neoplastic germ cell tissue
  14. BID, an interaction partner of protein kinase CK2α
  15. Monomeric and dimeric GDF-5 show equal type I receptor binding and oligomerization capability and have the same biological activity
  16. Novel ketomethylene inhibitors of angiotensin I-converting enzyme (ACE): inhibition and molecular modelling
  17. Identification of trypsin I as a candidate for influenza A virus and Sendai virus envelope glycoprotein processing protease in rat brain
  18. A fluorescence assay for rapid detection of ligand binding affinity to HIV-1 gp41
Heruntergeladen am 23.11.2025 von https://www.degruyterbrill.com/document/doi/10.1515/BC.2006.058/html?lang=de
Button zum nach oben scrollen