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Lipid Rafts in Protein Sorting and Cell Polarity in Budding Yeast Saccharomyces cerevisiae
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M. Bagnat
Published/Copyright:
June 1, 2005
Abstract
Cellular membranes contain many types and species of lipids. One of the most important functional consequences of this heterogeneity is the existence of microdomains within the plane of the membrane. Sphingolipid acyl chains have the ability of forming tightly packed platforms together with sterols. These platforms or lipid rafts constitute segregation and sorting devices into which proteins specifically associate. In budding yeast, Saccharomyces cerevisiae, lipid rafts serve as sorting platforms for proteins destined to the cell surface. The segregation capacity of rafts also provides the basis for the polarization of proteins at the cell surface during mating. Here we discuss some recent findings that stress the role of lipid rafts as key players in yeast protein sorting and cell polarity.
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Published Online: 2005-06-01
Published in Print: 2002-10-06
Copyright © 2002 by Walter de Gruyter GmbH & Co. KG
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Articles in the same Issue
- Biological Chemistry 125th Anniversary
- Kai Simons Felix Hoppe-Seyler Lecturer 2002
- Lipid Rafts in Protein Sorting and Cell Polarity in Budding Yeast Saccharomyces cerevisiae
- Paper of the Year 2001
- RNA-Mediated RNA Degradation in Transgene- and Virus-Induced Gene Silencing
- Immunopharmacology of CpG DNA
- Induction and Regulation of Endogenous Granulocyte Colony-Stimulating Factor Formation
- In the Cellular Garden of Forking Paths: How p38 MAPKs Signal for Downstream Assistance
- The Human Steroid Hydroxylases CYP11B1 and CYP11B2
- Rate-Limiting Steps in Cytochrome P450 Catalysis
- YidC, a Newly Defined Evolutionarily Conserved Protein, Mediates Membrane Protein Assembly in Bacteria
- Vascular Endothelial Growth Factor Receptor Family Genes: When Did the Three Genes Phylogenetically Segregate?
- The TNFTNF Receptor System
- Fast Regulation of Cytochrome P450 Activities by Phosphorylation and Consequences for Drug Metabolism and Toxicity
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- The Hyaluronan-Binding Serine Protease from Human Plasma Cleaves HMW and LMW Kininogen and Releases Bradykinin
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