14 Model-based dose selection for gene therapy for haemophilia B

Chapters in this book

1. Preface V
2. List of contributing authors
3. Part I Chemical engineering and medicine
4. 1 A systems engineering approach to medicine 3
5. Part II Modelling physiology
6. 2 Computational modelling in liver system and liver disease 21
7. 3 Inhaled aerosols as carriers of pulmonary medicines and the limitations of in vitro–in vivo correlation (IVIVC) methods 49
8. 4 Modelling drug permeation across the skin: a chemical engineering perspective 73
9. 5 Chemical engineering contribution to hemodialysis innovation: achieving the wearable artificial kidneys with nanomaterial-based dialysate regeneration 103
10. Part III Disease and treatment
11. 6 Precision medicine in hypothyroidism: an engineering approach to individualized levothyroxine dosing 127
12. 7 Glucose sensors in medicine: overview 167
13. 8 Macroscopic transport models for drugs and vehicles in cancer tissues 185
14. 9 Mathematical modelling of hollow-fiber haemodialysis modules 203
15. 10 Chemical engineering methods in better understanding of blood hydrodynamics in atherosclerosis disease 243
16. 11 On the development of pharmacokinetic models for the characterisation and diagnosis of von Willebrand disease 263
17. Part IV Pharmacokinetics and drug delivery
18. 12 An introduction to quantitative systems pharmacology for chemical engineers 293
19. 13 A novel strategy for brain cancer treatment through a multiple emulsion system for simultaneous therapeutics delivery 315
20. 14 Model-based dose selection for gene therapy for haemophilia B 333
21. 15 Lipid-based nanoparticles for nucleic acids delivery 359
22. Index