8 Macroscopic transport models for drugs and vehicles in cancer tissues
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Álvaro González-Garcinuño
Abstract
Modeling drug release in solid tumors is a convergence point between chemical engineering and medicine. Consequently, many studies have been conducted to unravel the mechanisms behind drug distribution after administration. In addition, several approaches have been explored, ranging from pharmacokinetic and pharmacodynamic models to microscopic transport models through macroscopic transport models. This chapter focuses on the latter, macroscopic transport models, and discusses how these models can predict the processes involved in drug delivery, in free form or vehicle transported. We start by presenting some of the differentiating physiological parameters in cancer tissues and then the main equations used for modeling, including fluid flow, mass transport, and cell uptake. Also, the use of some dimensionless parameters explaining the processes that control transportation will be examined. Lastly, the final section will explore the process employed for building geometries to simulate solid tumors, as well as current research being conducted on patient-specific simulations made using medical images.
Abstract
Modeling drug release in solid tumors is a convergence point between chemical engineering and medicine. Consequently, many studies have been conducted to unravel the mechanisms behind drug distribution after administration. In addition, several approaches have been explored, ranging from pharmacokinetic and pharmacodynamic models to microscopic transport models through macroscopic transport models. This chapter focuses on the latter, macroscopic transport models, and discusses how these models can predict the processes involved in drug delivery, in free form or vehicle transported. We start by presenting some of the differentiating physiological parameters in cancer tissues and then the main equations used for modeling, including fluid flow, mass transport, and cell uptake. Also, the use of some dimensionless parameters explaining the processes that control transportation will be examined. Lastly, the final section will explore the process employed for building geometries to simulate solid tumors, as well as current research being conducted on patient-specific simulations made using medical images.
Kapitel in diesem Buch
- Preface V
- List of contributing authors
-
Part I Chemical engineering and medicine
- 1 A systems engineering approach to medicine 3
-
Part II Modelling physiology
- 2 Computational modelling in liver system and liver disease 21
- 3 Inhaled aerosols as carriers of pulmonary medicines and the limitations of in vitro–in vivo correlation (IVIVC) methods 49
- 4 Modelling drug permeation across the skin: a chemical engineering perspective 73
- 5 Chemical engineering contribution to hemodialysis innovation: achieving the wearable artificial kidneys with nanomaterial-based dialysate regeneration 103
-
Part III Disease and treatment
- 6 Precision medicine in hypothyroidism: an engineering approach to individualized levothyroxine dosing 127
- 7 Glucose sensors in medicine: overview 167
- 8 Macroscopic transport models for drugs and vehicles in cancer tissues 185
- 9 Mathematical modelling of hollow-fiber haemodialysis modules 203
- 10 Chemical engineering methods in better understanding of blood hydrodynamics in atherosclerosis disease 243
- 11 On the development of pharmacokinetic models for the characterisation and diagnosis of von Willebrand disease 263
-
Part IV Pharmacokinetics and drug delivery
- 12 An introduction to quantitative systems pharmacology for chemical engineers 293
- 13 A novel strategy for brain cancer treatment through a multiple emulsion system for simultaneous therapeutics delivery 315
- 14 Model-based dose selection for gene therapy for haemophilia B 333
- 15 Lipid-based nanoparticles for nucleic acids delivery 359
- Index
Kapitel in diesem Buch
- Preface V
- List of contributing authors
-
Part I Chemical engineering and medicine
- 1 A systems engineering approach to medicine 3
-
Part II Modelling physiology
- 2 Computational modelling in liver system and liver disease 21
- 3 Inhaled aerosols as carriers of pulmonary medicines and the limitations of in vitro–in vivo correlation (IVIVC) methods 49
- 4 Modelling drug permeation across the skin: a chemical engineering perspective 73
- 5 Chemical engineering contribution to hemodialysis innovation: achieving the wearable artificial kidneys with nanomaterial-based dialysate regeneration 103
-
Part III Disease and treatment
- 6 Precision medicine in hypothyroidism: an engineering approach to individualized levothyroxine dosing 127
- 7 Glucose sensors in medicine: overview 167
- 8 Macroscopic transport models for drugs and vehicles in cancer tissues 185
- 9 Mathematical modelling of hollow-fiber haemodialysis modules 203
- 10 Chemical engineering methods in better understanding of blood hydrodynamics in atherosclerosis disease 243
- 11 On the development of pharmacokinetic models for the characterisation and diagnosis of von Willebrand disease 263
-
Part IV Pharmacokinetics and drug delivery
- 12 An introduction to quantitative systems pharmacology for chemical engineers 293
- 13 A novel strategy for brain cancer treatment through a multiple emulsion system for simultaneous therapeutics delivery 315
- 14 Model-based dose selection for gene therapy for haemophilia B 333
- 15 Lipid-based nanoparticles for nucleic acids delivery 359
- Index
