Abstract
Efficient syntheses of 3,4-dihydropyrimidin-2-(1H)-ones and the corresponding thioxo derivatives using 1,3-dibromo-5,5-dimethylhydantoin (DBH) catalysis of a one-pot three-component Biginelli reaction of aldehydes, ethyl acetoacetate, and urea or thiourea under microwave irradiation are described. The advantages of this method are its short reaction times, high yields of the products, inexpensive and commercially available catalyst, and solvent-free conditions. Typical isolated yields exceed 70 % for arylaldehydes (9 examples) and aliphatic aldehydes (2 examples).
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© 2008 Institute of Chemistry, Slovak Academy of Sciences
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Articles in the same Issue
- Polymer interfaces used in electrochemical DNA-based biosensors
- Integration of biomass drying with combustion/gasification technologies and minimization of emissions of organic compounds
- Application of hydrocolloids as baking improvers
- Simultaneous determination of 118 pesticide residues in Chinese teas by gas chromatography-mass spectrometry
- Modifications of spectrophotometric methods for total phosphorus determination in meat samples
- Modification and characterization of montmorillonite fillers used in composites with vulcanized natural rubber
- A new approach to nickel electrolytic colouring of anodised aluminium
- Solvent-free synthesis and properties of carboxymethyl starch fatty acid ester derivatives
- Reduction of silver nitrate by polyaniline nanotubes to produce silver-polyaniline composites
- Chemometrical analysis of computed QSAR parameters and their use in biological activity prediction
- Mild and efficient conversion of trifluoromethylarenes into tribromomethylarenes using boron tribromide
- 1,3-Dibromo-5,5-dimethylhydantoin as a useful reagent for efficient synthesis of 3,4-dihydropyrimidin-2-(1H)-ones under solvent-free conditions
- A new xanthone from the roots of Securidaca inappendiculata