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Hepatoprotective Effects and Antioxidant Role of Scutia myrtina on Paracetamol Induced Hepatotoxicity in Rats
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Ramanathan Sambath Kumar
Published/Copyright:
February 14, 2011
The hepatoprotective effect and antioxidant role of ethanol extract of Scutia myrtina (EESM) was evaluated against paracetamol induced liver damage in rats. The degree of protection was measured by using biochemical parameters such as serum transaminase (SGPT and SGOT), alkaline phosphatase (ALP), bilirubin, total protein and uric acid. Further, the effects of the extract on lipid peroxidation (LPO), glutathione (GSH), Vitamin C and Vitamin E, superoxide dismutase (SOD), and catalase (CAT) were estimated. The ethanol extract of Scutia myrtina (EESM) (100 and 200 mg/kg) produced significant (P < 0.05) hepatoprotective effect by decreasing the activity of serum enzymes, bilirubin, and lipid peroxidation, while it significantly increased the levels of protein, uric acid, GSH, Vitamin C, Vitamin E, SOD and CAT (P < 0.05). The effects of EESM were comparable to that of standard drug Silymarin. The results indicate that EESM shows hepatoprotective effects on paracetamol-induced liver damage in rat this may due to antioxidant and free radical scavenging activity of EESM.
Published Online: 2011-2-14
©2011 Walter de Gruyter GmbH & Co. KG, Berlin/Boston
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Keywords for this article
Scutia myrtina;
hepatoprotective effects;
antioxidant;
paracetamol;
serum enzyme
Articles in the same Issue
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- Antihypertensive and Vasorelaxant Effects of Cinnamomum zeylanicum Stem Bark Aqueous Extract in Rats
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