Abstract
Overweight (OW) and obesity (OB) have become prevalent issues in the global public health arena. Serving as a prominent risk factor for various chronic diseases, overweight/obesity not only poses serious threats to people’s physical and mental health but also imposes significant medical and economic burdens on society as a whole. In recent years, there has been a growing focus on basic scientific research dedicated to seeking the neural evidence underlying overweight/obesity, aiming to elucidate its causes and effects by revealing functional alterations in brain networks. Among them, dysfunction in the reward network (RN) and executive control network (ECN) during both resting state and task conditions is considered pivotal in neuroscience research on overweight/obesity. Their aberrations contribute to explaining why persons with overweight/obesity exhibit heightened sensitivity to food rewards and eating disinhibition. This review centers on the reward and executive control network by analyzing and organizing the resting-state and task-based fMRI studies of functional brain network alterations in overweight/obesity. Building upon this foundation, the authors further summarize a reward-inhibition dual-system model, with a view to establishing a theoretical framework for future exploration in this field.
Funding source: National Natural Science Foundation of China
Award Identifier / Grant number: 32271087
Funding source: Chongqing Technology Innovation and Application Demonstration Major Theme Special Project
Award Identifier / Grant number: 2023GJJL-ZXX0001
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Research ethics: Not applicable.
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Author contributions: The authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Competing interests: The authors state no conflict of interest.
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Research funding: This study was supported by National Natural Science Foundation of China (No. 32271087) and Chongqing Technology Innovation and Application Demonstration Major Theme Special Project (No. 2023GJJL-ZXX0001).
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Data availability: Not applicable.
References
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Articles in the same Issue
- Frontmatter
- The impact of poverty and socioeconomic status on brain, behaviour, and development: a unified framework
- A systematic review and meta-analysis of the preclinical and clinical results of low-field magnetic stimulation in cognitive disorders
- Research advancements on nerve guide conduits for nerve injury repair
- From nasal respiration to brain dynamic
- Cerebral autoregulation, spreading depolarization, and implications for targeted therapy in brain injury and ischemia
- Theta burst stimulation for enhancing upper extremity motor functions after stroke: a systematic review of clinical and mechanistic evidence
- Functional alterations in overweight/obesity: focusing on the reward and executive control network
Articles in the same Issue
- Frontmatter
- The impact of poverty and socioeconomic status on brain, behaviour, and development: a unified framework
- A systematic review and meta-analysis of the preclinical and clinical results of low-field magnetic stimulation in cognitive disorders
- Research advancements on nerve guide conduits for nerve injury repair
- From nasal respiration to brain dynamic
- Cerebral autoregulation, spreading depolarization, and implications for targeted therapy in brain injury and ischemia
- Theta burst stimulation for enhancing upper extremity motor functions after stroke: a systematic review of clinical and mechanistic evidence
- Functional alterations in overweight/obesity: focusing on the reward and executive control network