Temperature-responsive and biodegradable PVA:PVP k30:poloxamer 407 hydrogel for controlled delivery of human growth hormone (hGH)
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Azade Taheri
Abstract
Recombinant human growth hormone (rhGH) is used for replacement therapy of pediatric hypopituitary dwarfism. Growth rate in children was observed to be better on the daily injection schedule compared with the currently used therapeutic regimen of thrice a week injection. Thus, a controlled release formulation would overcome the drawback of traditional rhGH therapy such as the need for multiple injections. Poloxamers are a family of triblock copolymers consisting of two hydrophilic blocks of polyoxyethylene separated by a hydrophobic block of polyoxypropylene, which form micelles at low concentrations and form clear thermally reversible gels at high concentrations. We used poloxamer gels to develop a controlled release formulation of hGH. The objective of this study was to develop an in situ gel forming drug delivery system for hGH using the minimum possible ratio of poloxamer 407 (P407). Decreasing the concentration of poloxamer could reduce the risk of hypertriglyceridemia induction. Different additives were added to the poloxamer formulations. It was observed that among different additives polyvinylpyrrolidone k30 (PVP k30) and polyvinyl alcohol (PVA) decrease poloxamer concentration required to form in situ gelation from 18% to 10%. The dynamic viscoelastic properties of the samples were determined. Both the storage modulus and the loss modulus of the samples increased abruptly as the temperature passed a certain point. It can be concluded that combining P407 and PVP and PVA could be a promising strategy for preparation of thermally reversible in situ gel forming delivery systems of hGH with low poloxamer concentration.
©2011 by Walter de Gruyter Berlin New York
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- Meetings
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Articles in the same Issue
- Publisher’s Note
- Publisher’s Note
- Editorials
- What brings a child to the doctor? A lesson from hyperthyroidism
- Images in Pediatric Endocrinology
- Hypothalamic hamartoma causing precocious puberty in a female child
- Original Contributions
- Adiponectin moderates the relationship between adiposity and leptin in adolescents regardless of gender or race
- Obesity in children and adolescents: relationship to growth, pubarche, menarche, and voice break
- Studies of different female rat models of hypothalamic obesity
- Frequency of congenital hypothyroidism in neonatesin the Konya region, Turkey
- Thyroid dysfunctions in children detected in mass screening for congenital hypothyroidism
- A nutritional intervention study with hydrolyzed collagen in pre-pubertal Spanish children: influence on bone modeling biomarkers
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- Evidence of insulin-like growth factor binding protein-3 proteolysis during growth hormone stimulation testing
- Pediatric 25-hydroxyvitamin D concentrationsin neurofibromatosis type 1
- Temperature-responsive and biodegradable PVA:PVP k30:poloxamer 407 hydrogel for controlled delivery of human growth hormone (hGH)
- Patient Report Letters
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- Neurological Wilson’s disease with refractory rickets
- HNF1A mutation presenting with fetal macrosomia and hypoglycemia in childhood prior to onset of overt diabetes
- Pediatric Cushing’s disease due to pituitary hyperplasia
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- Normal adrenal function in an infant following a pregnancy complicated by maternal adrenal cortical carcinoma and mitotane exposure
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- High frequency of cardiac and behavioral complaints as presenting symptoms of hyperthyroidism in children
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- Familial occurrence of Turner syndrome: casual event or increased risk?
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- Co-existence of ADHD, autoimmune hypothyroidism and pituitary macroadenoma presenting in a behaviour clinic: a case report and brief review of the literature
- Virilizing para-adrenocortical adenoma associated with idiopathic-acquired generalized anhidrosis in an adolescent girl
- Concurrent occurrence of chronic lymphocytic thyroiditis with hypothyroidism and growth hormone deficiency in a Turner’s syndrome patient
- Patient report: sacral agenesis with hypopituitarism
- Meetings
- Meetings Calendar
