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Adiponectin moderates the relationship between adiposity and leptin in adolescents regardless of gender or race
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Vanessa Bundy
Published/Copyright:
April 14, 2011
Abstract
Objectives: To determine gender or race differences in associations between adiposity and leptin, and whether adiponectin moderates these relationships.
Methods: Subjects were 441 adolescents, 14–18 years old (44% black, 56% white; 50% female, 50% male). Percent body fat (%BF) was measured with dual-energy X-ray absorptiometry. Leptin and adiponectin were measured using immunoassays.
Results: Among the four groups (white boys, white girls, black boys and black girls), white girls had the highest adiponectin (p=0.0017) and black girls had the highest leptin (p=0.0164). Percent BF and leptin were positively correlated (p=0.0164). The %BF-leptin relationship was stronger in boys than girls (p<0.0001). Those with lower adiponectin had a stronger %BF-leptin relationship than those with high adiponectin in the entire sample (p=0.0220). Statistical models were adjusted for age, race, gender and the interaction between race and gender.
Conclusion: Our data suggest a protective metabolic interaction for adiponectin and lend additional support for obesity prevention strategies in adolescents.
Published Online: 2011-04-14
Published in Print: 2011-04-01
©2011 by Walter de Gruyter Berlin New York
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