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Virilizing para-adrenocortical adenoma associated with idiopathic-acquired generalized anhidrosis in an adolescent girl
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Pinar Gumus
Published/Copyright:
April 1, 2011
Abstract
Adrenocortical tumors are rare in childhood and adolescence. Virilization, alone or in combination with signs of overproduction of other adrenal hormones, is the most common clinical presentation. Here we report an unusual case of an African-American female adolescent presenting with idiopathic acquired generalized anhidrosis, dysregulation of body temperature, absence of adult body odor and dry skin in the face of a virilizing para-adrenocortical adenoma. Virilization signs regressed soon after removal of the tumor, but normalization of the 3α-androstenediol glucuronide (3α-AG) took longer compared to other measurable androgens; accompanied by anhidrosis. The association of remitting anhidrosis with normalized levels of 3α-AG suggests it might be a possible mechanism for anhidrosis. High 3α-AG levels might implicate the increased peripheral conversion of weak pro-androgens with different biochemical structure. We recommend obtaining 3α-AG beside other androgens in virilized patients with atypical dermatological symptoms in the face of hyperandrogenism.
Published Online: 2011-04-01
Published in Print: 2011-04-01
©2011 by Walter de Gruyter Berlin New York
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Keywords for this article
adolescence;
adrenal adenoma;
anhidrosis;
3α-androstenediol glucuronide;
virilization
Articles in the same Issue
- Publisher’s Note
- Publisher’s Note
- Editorials
- What brings a child to the doctor? A lesson from hyperthyroidism
- Images in Pediatric Endocrinology
- Hypothalamic hamartoma causing precocious puberty in a female child
- Original Contributions
- Adiponectin moderates the relationship between adiposity and leptin in adolescents regardless of gender or race
- Obesity in children and adolescents: relationship to growth, pubarche, menarche, and voice break
- Studies of different female rat models of hypothalamic obesity
- Frequency of congenital hypothyroidism in neonatesin the Konya region, Turkey
- Thyroid dysfunctions in children detected in mass screening for congenital hypothyroidism
- A nutritional intervention study with hydrolyzed collagen in pre-pubertal Spanish children: influence on bone modeling biomarkers
- Neonatal screening for congenital adrenal hyperplasia: transitory elevation of 17-hydroxyprogesterone
- Evidence of insulin-like growth factor binding protein-3 proteolysis during growth hormone stimulation testing
- Pediatric 25-hydroxyvitamin D concentrationsin neurofibromatosis type 1
- Temperature-responsive and biodegradable PVA:PVP k30:poloxamer 407 hydrogel for controlled delivery of human growth hormone (hGH)
- Patient Report Letters
- A novel EIF2AK3 mutation leading to Wolcott-Rallison syndrome in a Chinese child
- Neurological Wilson’s disease with refractory rickets
- HNF1A mutation presenting with fetal macrosomia and hypoglycemia in childhood prior to onset of overt diabetes
- Pediatric Cushing’s disease due to pituitary hyperplasia
- A 12-year-old Chinese girl with Cushing syndrome and virilization due to adrenocortical carcinoma
- Primary pigmented nodular adrenocortical disease: a case report in a 7-year-old girl
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