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How much is enough? Evaluation of adrenal function in children who undergo growth hormone stimulation test

  • Revi P. Mathew EMAIL logo , Barbara D. Duffy , Wenli Wang , Benjamin R. Saville and Andrew A. Bremer
Published/Copyright: April 28, 2012

Abstract

The objective was to determine the probability of receiving steroid treatment following an insulin tolerance test (ITT) for short-stature evaluation and to evaluate the utility of a subsequent cortrosyn stimulation test (CST) in determining adrenal sufficiency. We retrospectively analyzed the hypothalamic-pituitary-adrenal (HPA) axis evaluation in short-stature subjects during the 5-year period from January 2005 to December 2009. The probability of receiving steroid treatment was <10% when the maximum cortisol concentration during an ITT was <8.4 μg/dL. In the event of a suboptimal cortisol response during an ITT, only a single 1-μg CST is recommended for assessment of adrenal function.


Corresponding author: Revi P. Mathew, MD, FRCP, Monroe Carell Jr. Children’s Hospital at Vanderbilt, 2200 Children’s Way, 11134 DOT, Nashville, TN 37232, USA

Received: 2011-11-21
Accepted: 2011-12-15
Published Online: 2012-04-28
Published in Print: 2012-08-01

©2012 by Walter de Gruyter Berlin Boston

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