Comparison of the effect of Myrtus communis herbal and anti-hemorrhoid ointments on the hemorrhoid symptoms and quality of life in postpartum women with grade I and II internal hemorrhoid: A triple-blinded randomized controlled clinical trial

Jamileh Malekuti; Mojgan Mirghafourvand; Khadijeh Samadi; Fatemeh Abbasalizadeh; Laleh Khodaei

doi:10.1515/jcim-2018-0147

Article

Comparison of the effect of Myrtus communis herbal and anti-hemorrhoid ointments on the hemorrhoid symptoms and quality of life in postpartum women with grade I and II internal hemorrhoid: A triple-blinded randomized controlled clinical trial

Jamileh Malekuti , Mojgan Mirghafourvand , Khadijeh Samadi , Fatemeh Abbasalizadeh and Laleh Khodaei

Published/Copyright: August 21, 2019

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From the journal Journal of Complementary and Integrative Medicine Volume 16 Issue 4

Abstract

Introduction

Due to the effects of hemorrhoids on physical and mental health, this study aimed to compare the effect of Myrtus communis herbal and anti-hemorrhoid ointments on symptoms of hemorrhoid and quality of life (primary outcomes) and satisfaction of the treatment and side effects (secondary outcomes).

Methods

This triple-blind randomized controlled trial was performed on women with grade I and II hemorrhoid referring to health centers in Tehran, Iran, in 2017. Individuals were randomly assigned to two groups of 67 people through block randomization method. The intervention group received the Myrtus communis herbal ointment and the control group received anti-hemorrhoid ointment twice a day, every 12 ± 2 h, an applicator of the drug through the rectum for 4 weeks. The Colorectal Evaluation of a Clinical Therapeutics Scale (CORECTS) was used to assess the severity of symptoms of hemorrhoid. To assess the quality of life, the World Health Organization Quality of Life questionnaire (WHOQOL-BREF) was used to measure the general quality of life of participants. This questionnaire was completed once before the start of the study, then on the fourth and the eighth week after the start of the intervention. Repeated measure ANOVA, Chi-square, Mann–Whitney U and independent t-test were used for data analysis.

Results

The severity of all symptoms of hemorrhoid decreased in both two group and there was no statistically significant difference between the two groups (p>0.05). However, the mean of anal itching at 4 and 8 weeks after the intervention was significantly lower in the Myrtus communis ointment group (p<0.05). There was no significant difference between groups in terms of quality of life at 4 and 8 weeks after the intervention (p>0.05). There was a significant difference between the two groups in terms of satisfaction with the drug (p=0.019) and the participants in the Myrtus communis ointment group were more satisfied with their drug use.

Conclusions

Myrtus communis herbal ointment was able to reduce the symptoms of hemorrhoid in the affected women. Therefore, it is likely that the use of this drug will promote the health of mothers with hemorrhoid.

Keywords: anti-hemorrhoid ointmen; hemorrhoid; Myrtus communis herbal ointment; quality of life

Acknowledgments

Hereby, the Vice-Chancellor of Research at Tabriz University of Medical Sciences is appreciated for funding the project, as well as all the participating mothers in the study and the staff of the health centers of Tehran who cooperated in the sampling.

Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: Tabriz University of Medical Sciences.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2018-08-14

Accepted: 2019-02-28

Published Online: 2019-08-21

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Articles in the same Issue

https://doi.org/10.1515/jcim-2018-0147

Keywords for this article

anti-hemorrhoid ointmen; hemorrhoid; Myrtus communis herbal ointment; quality of life