Efficacy of curcuminoids for reducing postoperative pain after laparoscopic gynecologic surgery: A pilot randomized trial
-
Natacha Phoolcharoen
,
Shina Oranratanaphan
Abstract
Background
Curcuminoids, which are substances extracted from turmeric, have been proved to have anti-inflammatory and analgesic effects along with a good safety profile. This study aimed to evaluate the clinical efficacy of curcuminoids for reducing postoperative pain in patients who undergo laparoscopic gynecologic surgery.
Methods
From November 2016 to December 2017, participants were randomly assigned, by blocks of four, to the intervention and control arms of the study. Altogether, 60 patients who were to undergo laparoscopic gynecologic surgery at our institution were enrolled. Intraoperative findings were not significantly different between the two groups. One tablet of curcuminoid extract 250 mg was given to patients in the intervention group four times a day on postoperative days 1–3. Pain was evaluated at 24 and 72 h postoperatively using a 10-point visual analog scale (VAS).
Results
The median VAS score 24 h after surgery was 3 (1–6) in the intervention group and 4.5 (3–7) in the control group, with the difference reaching statistical significance (p=0.001). The median VAS at 72 h after surgery was 1 (0–2) in the intervention group and 2 (1–5) in the control group (p<0.001).
Conclusion
Curcuminoids may be an effective supplement to reduce pain severity postoperatively following laparoscopic gynecologic surgery.
Trial Registration
TCTR20180215001 www.clinicaltrials.in.th
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
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- Yogic practices on oxidative stress and of antioxidant level: a systematic review of randomized controlled trials
- Pre-clinical studies
- The effect of different partitions of seaweed Sargassum plagyophylum on depression behavior in mice model of despair
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- Antidiabetic and antioxidative properties of the hydro-methanolic extract (60:40) of rhizomes of Curcuma amada roxb. (Zingiberaceae) in streptozotocin-induced diabetic male albino rat: a dose-dependent study through biochemical and genomic approaches
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