The effect of different partitions of seaweed Sargassum plagyophylum on depression behavior in mice model of despair

Azadeh Mesripour; Neda Rabian; Afsaneh Yegdaneh

doi:10.1515/jcim-2018-0207

Article

The effect of different partitions of seaweed Sargassum plagyophylum on depression behavior in mice model of despair

Azadeh Mesripour , Neda Rabian and Afsaneh Yegdaneh

Published/Copyright: May 24, 2019

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From the journal Journal of Complementary and Integrative Medicine Volume 16 Issue 4

Abstract

Background

Seaweeds are a famous traditional food resource in some countries containing different types of secondary metabolites. These marine organisms have shown different biological activities. The aim of this study was to investigate the effects of hexane and methanol extracts of Sargassum plagyophylum on depression.

Methods

Sargassum plagyophylum was collected from Persian Gulf. The plant was extracted by maceration with methanol-ethyl acetate solvent. The extract was evaporated and partitioned by hexane and methanol solvents. The two partitions were administered i.p. to male mice either a single dose or for 7 days. Depression was evaluated by the forced swimming test (FST) which higher immobility time indicates depressive-like behavior.

Results

The immobility time during FST decreased significantly by all the doses of the hexane partitions (notably 40 mg/kg; 10 s ± 2 vs. 114 s ± 12 control group). However, only the lowest dose (20 mg/kg) of the methanol partition reduced immobility time during FST (23 s ± 8, p<0.001). Following the long term administration both of the partitions reduced the immobility time in FST (hexane 27 s ± 11, methanol 70 s ± 14, p<0.05 vs. control 140 s ± 14).

Conclusion

The hexane partition showed antidepressant effects not only by long-term administration but also by the single dose during FST. The 7 days therapy with methanol partition also induced antidepressant behavior, but only the lowest single dose reduced immobility in FST. The methanol partitions possibly have certain substance that interfered with behavior in the FST. Therefore, S. plagyophylum should be considered for further antidepressant studies.

Keywords: depression; forced swimming test; Persian Gulf; Sargassum; seaweed

Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: None declared.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

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Received: 2018-11-03

Accepted: 2019-01-27

Published Online: 2019-05-24

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Articles in the same Issue

https://doi.org/10.1515/jcim-2018-0207

Keywords for this article

depression; forced swimming test; Persian Gulf; Sargassum; seaweed