Correlation between obesity, gestational diabetes mellitus, and pregnancy outcomes: an overview

Mehrukh Zehravi; Mudasir Maqbool; Irfat Ara

doi:10.1515/ijamh-2021-0058

Article

Correlation between obesity, gestational diabetes mellitus, and pregnancy outcomes: an overview

Mehrukh Zehravi , Mudasir Maqbool and Irfat Ara

Published/Copyright: June 18, 2021

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From the journal International Journal of Adolescent Medicine and Health Volume 33 Issue 6

Abstract

Obesity has been identified mainly as a raise in the body’s adiposity leading to prolonged overshoot of caloric intake over expenditure. Obesity has significant health-altering implications which have been shown to be implicated in the pathogenesis and progression of other diseases through its extensive physiological assaults. The prevalence of overweight and obesity has been an increasing epidemic worldwide. The number of obese births was even on the increase, with an increasing number of women of reproductive age registering as obese. Obesity is related to adverse perinatal outcomes and increased morbidity and mortality in pregnant women. The potential risk for multiple antenatal, postpartum, intrapartum, and neonatal complications is maternal obesity. Greater risk of developing Gestational Diabetes Mellitus (GDM), pregnancy induced hypertension (PIH), pre-eclampsia, risk of venous embolism, increased need for labor induction, and cesarean sections in the mother have been recorded in a comprehensive analysis of pregnancy complications associated with obesity. The link between obesity, gestational diabetes, and pregnancy outcomes will be briefly shown in this article.

Keywords: correlation; diabetes; obesity; reproductive health

Corresponding author: Mudasir Maqbool, Research Scholar, Department of Pharmaceutical Sciences, University of Kashmir, Srinagar, Jammu and Kashmir, 190006, India, E-mail: bhatmudasir92@gmail.com

Acknowledgment

Authors would like to thank all the authors whose work has being reviewed for the compilation of this book chapter. Authors would like to thank Miss Khushboo Nazir for her valuable suggestions during the drafting of this manuscript.

References

1. World Health Organization. Obesity: preventing and managing the global epidemic: report of a WHO consultation; 1999:894 p, WHO Technical Report.Search in Google Scholar

2. Misra, A, Shrivastava, U. Obesity and dyslipidemia in South Asians. Nutrients 2013;5:2708–33. https://doi.org/10.3390/nu5072708.Search in Google Scholar PubMed PubMed Central

3. Misra, A, Khurana, L. Obesity-related non-communicable diseases: South Asians vs White Caucasians. Int J Obes 2011;35:167–87. https://doi.org/10.1038/ijo.2010.135.Search in Google Scholar PubMed

4. Dave, A, Maru, L, Daksha, S, Natu, N. Weight does matter! A study of effect of obesity on pregnancy and its outcome. J S Asian Fed Obstet Gynecol 2013;5:107–10.10.5005/jp-journals-10006-1239Search in Google Scholar

5. Mandal, D, Manda, S, Rakshi, A, Dey, RP, Biswas, SC, Banerjee, A. Maternal obesity and pregnancy outcome: a prospective analysis. J Assoc Phys India 2011;59:486–9.Search in Google Scholar

6. Kumari, P, Gupta, M, Kahlon, P, Malviya, S. Association between high maternal body mass index and feto-maternal outcome. J Obes Metab Res 2014;1:143. https://doi.org/10.4103/2347-9906.141140.Search in Google Scholar

7. Deshmukh, VL, Jadhav, M, Yelikar, K. Impact of HIGH BMI on pregnancy: maternal and foetal outcome. J Obstet Gynaecol India 2016;66:192–7. https://doi.org/10.1007/s13224-015-0825-3.Search in Google Scholar PubMed PubMed Central

8. Aziz, N, Kallur, SD, Nirmalan, PK. Implications of the revised consensus body mass indices for Asian Indians on clinical obstetric practice. J Clin Diagn Res 2014;8:OC01–3. https://doi.org/10.7860/JCDR/2014/8062.4212.Search in Google Scholar PubMed PubMed Central

9. Guelinckx, I, Devlieger, R, Beckers, K, Vansant, G. Maternal obesity: pregnancy complications, gestational weight gain and nutrition. Obes Rev 2008;9:140–50. https://doi.org/10.1111/j.1467-789x.2007.00464.x.Search in Google Scholar PubMed

10. Ngoga, E, Hall, D, Mattheyse, F, Grové, D. Outcome of pregnancy in the morbidly obese woman. S Afr Fam Pract 2009;51:345–51. https://doi.org/10.1080/20786204.2009.10873805.Search in Google Scholar

11. Leddy, MA, Power, ML, Schulkin, J. The impact of maternal obesity on maternal and fetal health. Rev Obstet Gynecol 2008;1:170–8.Search in Google Scholar

12. Usha Kiran, TS, Hemmadi, S, Bethel, J, Evans, J. Outcome of pregnancy in a woman with an increased body mass index. BJOG An Int J Obstet Gynaecol 2005;112:768–72. https://doi.org/10.1111/j.1471-0528.2004.00546.x.Search in Google Scholar PubMed

13. Sebire, NJ, Jolly, M, Harris, JP, Wadsworth, J, Joffe, M, Beard, RW, et al.. Maternal obesity and pregnancy outcome: a study of 287 213 pregnancies in London. Int J Obes 2001;25:1175–84. https://doi.org/10.1038/sj.ijo.0801670.Search in Google Scholar PubMed

14. Bhattacharya, S, Campbell, DM, Liston, WA, Bhattacharya, S. Effect of Body Mass Index on pregnancy outcomes in nulliparous women delivering singleton babies. BMC Publ Health 2007;7:168–72. https://doi.org/10.1186/1471-2458-7-168.Search in Google Scholar PubMed PubMed Central

15. Robinson, HE, O’connell, CM, Joseph, KS, McLeod, NL. Maternal outcomes in pregnancies complicated by obesity. Obstet Gynecol 2005;106:1357–64. https://doi.org/10.1097/01.aog.0000188387.88032.41.Search in Google Scholar

16. Liu, P, Xu, L, Wang, Y, Zhang, Y, Du, Y, Sun, Y, et al.. Association between perinatal outcomes and maternal pre-pregnancy body mass index. Obes Rev 2016;17:1091–102. https://doi.org/10.1111/obr.12455.Search in Google Scholar PubMed

17. Ovesen, P, Rasmussen, S, Kesmodel, U. Effect of prepregnancy maternal overweight and obesity on pregnancy outcome. Obstet Gynecol 2011;118:305–9. https://doi.org/10.1097/aog.0b013e3182245d49.Search in Google Scholar

18. Keaney, JFJr, Larson, MG, Vasan, RS, Wilson, PW, Lipinska, I, Corey, D, et al.. Obesity and systemic oxidative stress: clinical correlates of oxidative stress in the Framingham Study. Arterioscler Thromb Vasc Biol 2003;23:434–9. https://doi.org/10.1161/01.atv.0000058402.34138.11.Search in Google Scholar PubMed

19. Skalicky, J, Muzakova, V, Kandar, R, Meloun, M, Rousar, T, Palicka, V. Evaluation of oxidative stress and inflammation in obese adults with metabolic syndrome. Clin Chem Lab Med 2008;46:499–505. https://doi.org/10.1515/CCLM.2008.096.Search in Google Scholar PubMed

20. Dulloo, AG, Jacquet, J, Solinas, G, Montani, J-P, Schutz, Y. Body composition phenotypes in pathways to obesity and the metabolic syndrome. Int J Obes 2010;34:S4–17. https://doi.org/10.1038/ijo.2010.234.Search in Google Scholar PubMed

21. Sikaris, KA. The clinical biochemistry of obesity. Clin Biochem Rev 2004;25:165–81.Search in Google Scholar

22. Fonseca-Alaniz, MH, Takada, J, Alonso-Vale, MIC, Lima, FB. Adipose tissue as an endocrine organ: from theory to practice. J Pediatr 2007;83:S192–203. https://doi.org/10.1590/s0021-75572007000700011.Search in Google Scholar

23. Jarvie, EM. Anatomical fat distribution and accumulation and lipotoxicity in lean and obese pregnancy [Doctoral dissertation]. University of Glasgow; 2015.Search in Google Scholar

24. Ramsay, JE, Greer, I, Sattar, N. Obesity and reproduction. BMJ 2006;333:1159–62. https://doi.org/10.1136/bmj.39049.439444.de1.Search in Google Scholar PubMed PubMed Central

25. Huda, SS, Brodie, LE, Sattar, N. Obesity in pregnancy: prevalence and metabolic consequences. Semin Fetal Neonatal Med 2010;15:70–6. https://doi.org/10.1016/j.siny.2009.09.006.Search in Google Scholar PubMed

Received: 2021-04-22

Accepted: 2021-05-09

Published Online: 2021-06-18

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Articles in the same Issue

https://doi.org/10.1515/ijamh-2021-0058

Keywords for this article

correlation; diabetes; obesity; reproductive health