Zeitschrift

Journal of Basic and Clinical Physiology and Pharmacology

Editor-in-Chief: Ugo Oliviero
Managing Editor: Alberto Marra

Sprache: Englisch

Erstveröffentlichung: 1. Dezember 1986

Erscheinungsweise: 6 Hefte pro Jahr

Neuestes Heft anzeigen

Veröffentlicht von

Veröffentlichen auch Sie bei De Gruyter Brill

Manuskript einreichen Informationen für Autor*innen Erkunden Sie dieses Fachgebiet

Über diese Zeitschrift

Objective
The Journal of Basic and Clinical Physiology and Pharmacology (JBCPP) is a peer-reviewed bi-monthly published journal in experimental medicine. JBCPP publishes novel research in the physiological and pharmacological sciences, including Emergency Medicine, Oncology, Hematology and Coagulation disorders, Vascular Medicine, Gastroenterology, Liver Disease, Neurology and Cerebrovascular Diseases, Gender Medicine, Endocrinology, Diabetology and Metabolism, Cardiovascular Diseases, Heart Failure, Respiratory Disease, Geriatrics, Immunology and Rheumatology.

Moreover, Manuscripts regarding basic and laboratory sciences will be very welcome.

As the borders between physiology, pharmacology and biochemistry become increasingly blurred, we also welcome papers using cutting-edge techniques in cellular and/or molecular biology to link descriptive or behavioral studies with cellular and molecular mechanisms underlying the integrative processes.　

Topics

Emergency Medicine
Oncology
Hematology and Coagulation disorders
Vascular Medicine
Gastroenterology
Liver Disease
Neurology and Cerebrovascular Diseases
Gender Medicine
Endocrinology
Diabetology and Metabolism
Cardiovascular Diseases
Heart Failure
Respiratory Disease
Geriatrics
Immunology
Rheumatology

Article formats
Research Articles, Reviews and Mini Reviews, Short Communications, Editorials and Letters to the Editor

Ihre Vorteile

State-of-the-art research in physiology and pharmacology
Integrative approach to descriptive and behavioral studies
Leading-edge techniques
High quality peer-review

Geschichte

Founded in 1990
Increase of contents and issue numbers from 4 to 6 in 2015
Online-only as of 2019

Other publications in the field

Erfordert eine Authentifizierung Nicht lizenziert
Lizenziert

Atrioventricular block and myastenia gravis. A case report and review of the literature

1. Oktober 2025

Anna Lombardi, Francesco Murru, Luigi Giuseppe Atripaldi, Carmine D’Argenzio, Rita Verdoliva, Giordana G. Iannibelli, Claudia Canitano, Mariarosaria De Luca, Giuseppe Cudemo, Rosa Lucci, Andrea Salzano, Alberto M. Marra, Michele Arcopinto, Antonio Cittadini

PDF downloaden

Objectives Myasthenia gravis (MG) is a chronic autoimmune disease primarily affecting skeletal muscles, though cardiac involvement, particularly arrhythmias, may occur, especially in severe cases or in patients with thymoma. Case presentation We report the case of a 62-year-old male with AchR-Ab-positive MG, without thymoma, who developed an advanced atrioventricular block requiring pacemaker implantation. Cardiac manifestations in MG can result from either the disease itself – through myocarditis, autoantibodies and autonomic dysfunction – or as a side effect of treatments such as pyridostigmine and immunosuppressants. Management strategies include considering discontinuation of pyridostigmine or using hyoscyamine to assess potential drug-induced bradyarrhythmias before proceeding with permanent pacing. Conclusions This case highlights the diagnostic challenges in distinguishing iatrogenic from autoimmune cardiac complications and emphasizes the importance of cardiovascular monitoring in MG patients, especially those presenting with cardiac symptoms or EKG abnormalities. Early recognition and appropriate intervention are crucial to improve outcomes and quality of life.
Erfordert eine Authentifizierung Nicht lizenziert
Lizenziert

Mental toughness and athletic performance: a narrative review

25. September 2025

Raja Soundara Pandian Pachaiappan, Veera Balajikumar Veeraswamy, Kannan Mahalingam, Gurubharathy Gurusamy, Bijulakshmi Parthiban

PDF downloaden

Background Mental toughness represents a crucial psychological construct in competitive sports. This narrative review examines the relationship between mental toughness and athletic performance across various sports domains. Methods We conducted a comprehensive literature review of empirical studies published between 2000 and 2024. Relevant articles were identified through database searches including PubMed, PsycINFO, SPORTDiscus, and Web of Science. Studies examining mental toughness in relation to performance outcomes in competitive athletes were included. Results Evidence consistently shows positive correlations between mental toughness and athletic performance (r=0.21–0.63). Mental toughness demonstrates stronger associations with performance in individual sports compared to team sports. Additionally, psychological interventions targeting mental toughness components show promise for enhancing athletic outcomes. Conclusions Mental toughness represents a significant psychological factor in athletic achievement. The construct influences performance through multiple pathways including resilience to pressure, emotional regulation, and focus maintenance. Practical applications for coaches and sport psychologists are discussed.
Erfordert eine Authentifizierung Nicht lizenziert
Lizenziert

Evaluation of polypharmacy and appropriateness of prescription in geriatric patients using Beer’s criteria at tertiary care hospital: a record based retrospective study

18. September 2025

Geetanjali Hiremath, Radhika Sherkhane, Shrikant Hiremath

PDF downloaden

Objectives The current study aims to evaluate the aptness of prescription in elderly along with looking out for polypharmacy, overprescribing and under prescribing in geriatric patients being treated at the tertiary care hospital. Methods This is a retrospective record-based study, data was collected from 1st January 2017 to 31st December 2018 of all the patient which are falling in the inclusion criteria. Prescription appropriateness was assessed implementing ‘Beers criteria’. Errors in prescription along with administration were checked by direct observation and analysis of prescriptions. Results Out of total 2,718 patients, 58.6 % were found to be males and 41.4 % were females. Most common comorbidities found were hypertension and coronary artery diseases (CAD). In the current study, 39 % of the prescription contained inappropriate medication and 11.20 % prescriptions were having adverse drug reaction. Error by attending nurse in prescription reading came out to be the most common error in this study. Conclusions Diclofenac was found to be the most commonly used inappropriate drug as per Beer’s criteria. Clinicians should be more cautious when using drugs in old age patients.
Erfordert eine Authentifizierung Nicht lizenziert
Lizenziert

A cross-sectional observational study of the prevalence and characterization of potential QT-prolonging drug‒drug interactions in oncological outpatients

12. August 2025

Akash Agnihotri, Biswadeep Das, Sachin Manocha, Manjunath Bidarolli, Bharati Vashisht

PDF downloaden

Objectives This study aims to assess the prevalence, characteristics, and risk factors of potential QT-prolonging drug–drug interactions (pQT-DDIs) in cancer patients, including identifying drug combinations contributing to QT prolongation and key predictors. Methods In this hospital-based, cross-sectional observational study, all types of cancer patients, irrespective of age or sex, were included over 1 year. pQT-DDIs were identified using four drug interaction checker software tools. Predictors were analyzed using univariate logistic regression. Results A total of 1,331 cancer patients were included. The prevalence of pQT-DDIs was 67.6 %. Of these, 606 (45.5 %) had 1–2 pQT-DDIs, 126 (9.5 %) had 3–4, and 78 (5.9 %) had 5–6. Overall, 163 drug combinations were identified as causing QT prolongation; 122 were detected by Drugs.com. Significant predictors included >8 drugs prescribed (OR=6.46; CI=4.87–8.56; p<0.0001), >2 anticancer drugs (OR=1.68; CI=1.14–2.46; p=0.008), >6 adjuvant drugs (OR=6.83; CI=5.17–9.03; p<0.0001), solid cancers (OR=6.59; CI=4.59–8.80; p<0.0001), and cytotoxic drug use (OR=2.40; CI=1.52–3.77; p=0.0001). Conclusions There is a high prevalence of pQT-DDIs in cancer patients. Those receiving multiple anticancer and adjuvant drugs are at higher risk. Routine interaction screening is recommended before chemotherapy.
Erfordert eine Authentifizierung Nicht lizenziert
Lizenziert

Physiological belching during impedance-pH monitoring: a meal with Coca-Cola provokes a prompt gastroesophageal reaction with increased prandial belching

21. Juli 2025

Alessandra B. Melchior, Martina E. Da Cas, Nicolle Surkamp, Victória Zamprogna, Matheus P. Silveira, Tarcisio S. Santos, Lucas Z. Montenegro, Luiza M. Volpi, Fernando Fornari

PDF downloaden

Objectives To assess the belching-related esophageal events in healthy volunteers during and after fast-food meals. Methods Ten adult healthy volunteers had two lunches with a Big Mac ® on different days, accompanied or not by Coca-Cola (500 mL, pH<3) in a random way. We assessed prandial and 2 h postprandial esophageal events using impedance-pH monitoring. Results During meals with Coca-Cola, most signed belching (68 %) were concomitant with prolonged esophageal acidification or acid reflux, and the belching number was superior [median: 9.5 (IQR 4.7–14) vs. 0 (0–3); p=0.002] and less frequently represented by pure gas (24 % vs. 92 %; p<0.001) than in meals without Coca-Cola. Postprandial belching did not differ either in frequency [median: 15.5 (6–20.2) vs. 13.5 (10.7–20.5); p=0.739] or in type [(median %) pure gas: 6.7 % vs. 11.7 %; during acid reflux: 64.6 % vs. 51.7 %; during nonacid reflux: 22.5 % vs. 22.2 %; p=0.300), with more than 80 % of belching coincident with asymptomatic liquid reflux, regardless of Coca-Cola intake. Postprandial gastroesophageal reflux and esophageal acid exposure were similar, irrespective of Coca-Cola intake. Conclusions In healthy volunteers, a fast-food meal with Coca-Cola provoked a prompt reaction with increased prandial belching and esophageal acidification. Coca-Cola did not change postprandial belching, often accompanied by silent gastroesophageal liquid reflux.
Erfordert eine Authentifizierung Nicht lizenziert
Lizenziert

The current pathogenicity and potential risk evaluation of Ebola virus to cause mysterious disease X – An update on recent evidences

1. Januar 2000

Abir Hasan Pranto, Md. Rabiul Islam

PDF downloaden
Erfordert eine Authentifizierung Nicht lizenziert
Lizenziert

Association of adiponectin and nutritional indices with sarcopenia in elderly diabetic patients

1. Januar 2000

Aruna Raju, Jean Fredrick, Asmita Hazra, Boudhayan Das Munshi, Debarati Guha Roy

PDF downloaden

Objectives To assess the relationship between adiponectin levels, nutritional indices, and sarcopenia in elderly diabetic patients, and to identify metabolic and nutritional biomarkers that distinguish sarcopenic from non-sarcopenic elderly diabetic individuals. Methods This cross-sectional study included 80 diabetic patients aged >60 years, sarcopenic (n=40) and non-sarcopenic (n=40) groups based on Asian Working Group for Sarcopenia criteria. Serum adiponectin, glucose metabolism markers, lipid profiles, and nutritional indices including prognostic nutritional index (PNI), geriatric nutritional risk index (GNRI), and controlling nutritional status (CONUT) score were assessed. Results Sarcopenic patients demonstrated significantly higher adiponectin levels (12.8 ± 3.4 vs. 8.4 ± 2.1 μg/mL, p<0.001), representing a 52% increase compared to non-sarcopenic individuals. The sarcopenic group showed impaired insulin sensitivity (QUICKI: 0.31 ± 0.05 vs. 0.36 ± 0.04, p=0.003), elevated atherogenic indices, and reduced nutritional status. All nutritional indices were significantly impaired in the sarcopenic group: PNI (45.2 ± 5.4 vs. 52.4 ± 6.8, p<0.001), GNRI, and CONUT score. Multiple logistic regression identified adiponectin (OR=1.264, 95% CI: 1.062–1.504, p=0.009), age, insulin resistance, and nutritional indices as independent predictors of sarcopenia. Conclusions Elevated adiponectin levels paradoxically associate with sarcopenia in elderly diabetes, suggesting a potential biomarker for muscle wasting. The association between nutritional indices and sarcopenia emphasizes the importance of comprehensive nutritional assessment in elderly diabetic patients.
Erfordert eine Authentifizierung Nicht lizenziert
Lizenziert

Menopause, estrogen, and GERD: an exploration of symptoms and endoscopic correlations

1. Januar 2000

Praveena Meyyazhagan, Pavitra Vyshnavi Yogisparan, Thendral Anandaraj

PDF downloaden

Objectives To define the pattern of symptoms and severity of GERD among premenopausal and postmenopausal women in relation to estrogen levels and endoscopy findings. Methods The research was carried out in the Laboratory of Gastrointestinal Motility inside the Gastroenterology Department at PSGIMS&R, Coimbatore and the following approval from Institutional Human Ethics Committee (IHEC). Results The findings reveal significant variations in estrogen levels between premenopausal and postmenopausal women with gastroesophageal reflux disease (GERD), with premenopausal women having higher levels (82.80 ± 27.91 to 150.43 ± 40.80 pg/mL) compared to postmenopausal women (6.05 ± 2.75 to 17.30 ± 5.43 pg/mL, p < 0.001). This decline in estrogen post-menopause is associated with increased GERD symptoms and endoscopic abnormalities. Conclusion The study concludes that reduced estrogen levels in postmenopausal women are linked to a higher prevalence of GERD symptoms, including heartburn and dysphagia, compared to premenopausal women. Endoscopic findings further support the correlation between hormonal changes and GERD severity, highlighting the necessity for careful evaluation of GERD risk factors.

CiteScore	4.2	2024, Scopus (Elsevier B.V., 2025)
SCImago Journal Rank	0.487	2024, SJR (Scimago Lab, 2025; Data Source: Scopus)
Source Normalized Impact per Paper	0.541	2024, CWTS Journal Indicators (CWTS B.V., 2025; Data Source: Scopus)

Journal of Basic and Clinical Physiology and Pharmacology

Übersicht

Über diese Zeitschrift

Ihre Vorteile

Geschichte

Ahead-of-Publication / Just-Accepted

Ausgaben

Metriken

Einreichen

Editorial

Abstracting und Indexing

Zusatzmaterial

Zusatzmaterial

Fachgebiete

Fachgebiete

Externe Links

Bibliographische Daten