Novel tetrazole PtII and PdII complexes with enhanced water solubility: synthesis, structural characterization and evaluation of antiproliferative activity
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Tatiyana V. Serebryanskaya
und
Oleg A. Ivashkevich
Abstract
Novel platinum(II) and palladium(II) chlorido complexes with tetrazole derivatives 1-(2-hydroxyethyl)tetrazole (het) and 1-[tris(hydroxymethyl)methyl]tetrazole (thm), viz. cis-[Pt(het)2Cl2], trans-[Pt(het)2Cl2], trans-[Pt(thm)2Cl2], trans-[Pd(het)2Cl2], and trans-[Pd(thm)2Cl2], were synthesized. The compounds were characterized by elemental and high-resolution electrospray ionization (HRESI) mass spectrometry, high-performance liquid chromatography (HPLC), 1H, 13C and 195Pt nuclear magnetic resonance (NMR) spectroscopy, thermal analyses, and Infrared (IR) spectroscopy. Molecular and crystal structures of trans-[PdL2Cl2] and trans-[PtL2Cl2] (L = het, thm) were established by single-crystal X-ray analysis. The complex cis-[Pt(het)2Cl2] was found to undergo cis–to–trans isomerization upon heating in acetonitrile solution and in the solid state. The synthesized complexes show rather high water solubility lying in the range of 2–10 mg/L.
Funding source: Russian Foundation for Basic Research
Award Identifier / Grant number: 20-53-00006
Funding source: Belarusian Foundation for Fundamental Research
Award Identifier / Grant number: X20P-066
Award Identifier / Grant number: 075-03-2020-223 (FSSF-2020-0017)
Acknowledgments
Funding for this research was provided by Russian Foundation for Basic Research (project number 20-53-00006) and Belarusian Foundation for Fundamental Research (grant X20P-066). We acknowledge the RUDN University Program 5-100. Funding for this research was provided by Ministry of Science and Higher Education of the Russian Federation (award no. 075-03-2020-223 (FSSF-2020-0017)).
Author contribution: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: Funding for this research was provided by Russian Foundation for Basic Research (project number 20-53-00006) and Belarusian Foundation for Fundamental Research (grant X20P-066). We acknowledge the RUDN University Program 5-100. Funding for this research was provided by Ministry of Science and Higher Education of the Russian Federation (award no. 075-03-2020-223 (FSSF-2020-0017)).
Competing interests: The authors declare no conflicts of interest regarding this article.
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Supplementary Material
The online version of this article offers supplementary material (https://doi.org/10.1515/zkri-2020-0082).
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Artikel in diesem Heft
- Frontmatter
- In this issue
- Original papers
- Phase stability analysis of shocked ammonium dihydrogen phosphate by X-ray and Raman scattering studies
- Effect of solution acidity on the crystallization of polychromates in uranyl-bearing systems: synthesis and crystal structures of Rb2[(UO2)(Cr2O7)(NO3)2] and two new polymorphs of Rb2Cr3O10
- Novel tetrazole PtII and PdII complexes with enhanced water solubility: synthesis, structural characterization and evaluation of antiproliferative activity
- Hydrogen-bonding in mono-, di- and tetramethylammonium dihydrogenphosphites
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Artikel in diesem Heft
- Frontmatter
- In this issue
- Original papers
- Phase stability analysis of shocked ammonium dihydrogen phosphate by X-ray and Raman scattering studies
- Effect of solution acidity on the crystallization of polychromates in uranyl-bearing systems: synthesis and crystal structures of Rb2[(UO2)(Cr2O7)(NO3)2] and two new polymorphs of Rb2Cr3O10
- Novel tetrazole PtII and PdII complexes with enhanced water solubility: synthesis, structural characterization and evaluation of antiproliferative activity
- Hydrogen-bonding in mono-, di- and tetramethylammonium dihydrogenphosphites
- Photophysical property change of N-(5-bromo-salicylidene)-3-aminoethylpyridine monohydrated crystals via dehydration phase transition
