Startseite Fabrication of porous polymeric structures using a simple sonication technique for tissue engineering
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Fabrication of porous polymeric structures using a simple sonication technique for tissue engineering

  • Alan Saúl Álvarez-Suarez , Eduardo Alberto López-Maldonado , Olivia A. Graeve , Fabián Martinez-Pallares , Luis Enrique Gómez-Pineda , Mercedes Teresita Oropeza-Guzmán , Ana Leticia Iglesias , Theodore Ng , Eduardo Serena-Gómez und Luis Jesús Villarreal-Gómez EMAIL logo
Veröffentlicht/Copyright: 8. September 2017
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Abstract

Porous polymeric scaffolds have been applied successfully in the biomedical field. This work explores the use of an ultrasonic probe to generate cavitation in a polymeric solution, thus producing pores in the polymeric scaffolds. Porous polymeric structures with average pore sizes ranging from 5 to 63 μm and porosity of 6–44% were fabricated by a process consisting of sonication, flash freezing, and lyophilization of poly(lactic-co-glycolic acid) (PLGA), gelatin (GEL), chitosan (CS) and poly(vinyl alcohol) (PVAL) solutions. Pore structure was characterized by scanning electron microscopy (SEM) and image analysis software. The infrared spectra were analyzed before and after the fabrication process to observe any change in the chemical structure of the polymers. A water absorption test indicated the susceptibility of the samples to retain water in their structure. TGA results showed that GEL experienced degradation at 225°C, CS had a decomposition peak at 280°C, the thermal decomposition of PLGA occurred at 375°C, and PVAL showed two degradation regions. The DSC analysis showed that the glass transition temperature (Tg) of GEL, CS, PLGA and PVAL occurred at 70°C, 80°C, 60°C and 70°C, respectively. The fabricated porous structures demonstrated similar physical characteristics to those found in bone and cartilage.

Acknowledgment

The authors are grateful for the support by “Programa para el Desarrollo de Personal Docente, Secretaria de EducaciónPublica” (PRODEP-SEP; project no. UABC-PTC-629).

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Received: 2016-11-24
Accepted: 2017-7-11
Published Online: 2017-9-8
Published in Print: 2017-11-27

©2017 Walter de Gruyter GmbH, Berlin/Boston

Heruntergeladen am 3.12.2025 von https://www.degruyterbrill.com/document/doi/10.1515/polyeng-2016-0423/pdf
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