Neonatal outcome in infants of patients with radical vaginal trachelectomy
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Mandy Mangler
Abstract
Objective: Radical vaginal trachelectomy (RVT) as a fertility-preserving surgery in patients with early-stage cervical cancer is proven to be oncologically safe. After RVT, pregnancy rates vary between 40% and 80%. Outcome of infants is complicated by a preterm delivery rate of 30–50%. We investigated pregnancy and neonatal outcome after RVT.
Methods: A total of 154 patients with cervical cancer underwent RVT between March 1995 and February 2008. Desire to conceive, pregnancy data, and neonatal outcome were prospectively recorded. Infants’ data were pair-matched to data of a control group according to weeks of gestation. Bayley scales of infant development scores were recorded in the group of preterm-delivered infants.
Results: Fifty-five women who underwent RVT gave birth to 58 children. Twenty-five (43%) pregnancies were complicated by preterm rupture of membranes. Thirty infants (52%) were born preterm, of with 17 (29%) were <32 gestational weeks (GW) and seven (12%) were <28 GW. There were significantly more premature rupture of membranes in pregnancies after RVT. Despite a higher occurrence of postnatal infections in newborns of mothers who underwent RVT, long-term outcomes are not affected negatively. Regarding overall morbidity, a trend to fewer postnatal complications, compared with the control group, was found.
Conclusion: Postnatal morbidity in infants of women who underwent RVT, based on trend, is decreased compared with controls. Intense medical observation and treatment during pregnancy, birth, and neonatal period may explain this finding. Neonates in the RVT group have a non-significantly elevated risk for postnatal infections. They do not show an additional risk due to the maternal operation. Their long-term postnatal outcome is not affected negatively.
©2012 by Walter de Gruyter Berlin Boston
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Artikel in diesem Heft
- Masthead
- Masthead
- Original Articles – Obstetrics
- Intravenous iron treatment in pregnancy: comparison of high-dose ferric carboxymaltose vs. iron sucrose
- Trophoblastic progranulin expression is upregulated in cases of fetal growth restriction and preeclampsia
- Can a customized standard for large for gestational age identify women at risk of operative delivery and shoulder dystocia?
- Can discordance in CRL at the first trimester predict birth weight discordance in twin pregnancies?
- Anxiety and deterioration of quality of life factors associated with recurrent miscarriage in an observational study
- Neonatal outcome in infants of patients with radical vaginal trachelectomy
- The prevalence of gestational diabetes in advanced economies
- First-trimester reference ranges for decidual thickness and its relation to progesterone levels
- Original Articles – Fetus
- Levels of cytokines in umbilical cord blood in relation to spontaneous term labor
- Survival and neonatal outcome after fetoscopic guided laser occlusion (FLOC) of twin-to-twin transfusion syndrome (TTTS) in Sweden
- Is it necessary to induce labor in cases of intrauterine growth restriction at term?
- Fetal myocardial peak systolic strain before and after intrauterine red blood cell transfusion – a tissue Doppler imaging study
- Delayed interval delivery in twin and triplet pregnancies: 6 years of experience in one perinatal center
- Original Articles – Newborn
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- Congress Calendar
- Congress Calendar
