Trophoblastic progranulin expression is upregulated in cases of fetal growth restriction and preeclampsia
-
Johannes Stubert
,
Florian Schattenberg
Abstract
Aims: The expression of the anti-inflammatory glycoprotein progranulin and the hypoxia-induced transcription factor 1α (HIF-1α) in the villous trophoblast was compared between placentae from patients with preeclampsia (PE), fetal growth restriction (FGR), and normal controls.
Study design: Matched pairs analysis of third trimester placentae specimens (mean gestational age 36+2) was performed by semiquantitative measurements of the immunohistochemical staining intensities for progranulin and HIF-1α expression (PE n=13, FGR n=9 and controls n=11). Further, placental progranulin mRNA expression was analyzed by qRT-PCR on term placentae (n=3 for each group).
Results: Compared to controls, villous trophoblast revealed a significantly higher expression of progranulin in cases of PE (P<0.05) and FGR (P<0.01). Similar results were shown for HIF-1α expression (P<0.01 for PE and <0.05 for FGR). The increase of the progranulin protein was not accompanied by an increase of the progranulin mRNA in term placentae.
Conclusions: Increased expression of progranulin protein in villous trophoblast cells in cases of PE and FGR may result from disturbed placental development and, therefore, may be of pathogenetic importance. The increase was correlated to HIF-1α expression. Further evaluation of this potential mechanism of regulation is required.
©2012 by Walter de Gruyter Berlin Boston
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Articles in the same Issue
- Masthead
- Masthead
- Original Articles – Obstetrics
- Intravenous iron treatment in pregnancy: comparison of high-dose ferric carboxymaltose vs. iron sucrose
- Trophoblastic progranulin expression is upregulated in cases of fetal growth restriction and preeclampsia
- Can a customized standard for large for gestational age identify women at risk of operative delivery and shoulder dystocia?
- Can discordance in CRL at the first trimester predict birth weight discordance in twin pregnancies?
- Anxiety and deterioration of quality of life factors associated with recurrent miscarriage in an observational study
- Neonatal outcome in infants of patients with radical vaginal trachelectomy
- The prevalence of gestational diabetes in advanced economies
- First-trimester reference ranges for decidual thickness and its relation to progesterone levels
- Original Articles – Fetus
- Levels of cytokines in umbilical cord blood in relation to spontaneous term labor
- Survival and neonatal outcome after fetoscopic guided laser occlusion (FLOC) of twin-to-twin transfusion syndrome (TTTS) in Sweden
- Is it necessary to induce labor in cases of intrauterine growth restriction at term?
- Fetal myocardial peak systolic strain before and after intrauterine red blood cell transfusion – a tissue Doppler imaging study
- Delayed interval delivery in twin and triplet pregnancies: 6 years of experience in one perinatal center
- Original Articles – Newborn
- Rapid neonatal weight gain increases risk of childhood overweight in offspring of diabetic mothers
- Factors that affect the postnatal increase in superior mesenteric artery blood flow velocity in very low birth weight preterm infants
- Central-peripheral temperature gradient: an early diagnostic sign of late-onset neonatal sepsis in very low birth weight infants
- A practical method for reducing blindness due to retinopathy of prematurity in a developing country
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- Congress Calendar
