Evening primrose oil for cervical ripening in term pregnancies: a systematic review and meta-analysis

Shahla Hemmatzadeh; Sakineh Mohammad Alizadeh Charandabi; Afsaneh Veisy; Mojgan Mirghafourvand

doi:10.1515/jcim-2020-0314

Artikel

Evening primrose oil for cervical ripening in term pregnancies: a systematic review and meta-analysis

Shahla Hemmatzadeh , Sakineh Mohammad Alizadeh Charandabi , Afsaneh Veisy und Mojgan Mirghafourvand

Veröffentlicht/Copyright: 14. Juli 2021

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Aus der Zeitschrift Journal of Complementary and Integrative Medicine Band 20 Heft 2

Abstract

Induction of labor by using available, inexpensive and non-invasive methods with the least side effects is particularly important. A systematic review was conducted to assess the effect of evening primrose oil on cervical ripening in term pregnancies. In this systematic review and meta-analysis of clinical trials, a search was carried out in PubMed, Cochrane Library, Embase, Ovid, Scopus, Clinical Trials.gov, Google Scholar and Persian databases (Magiran, SID, and IRCT.ir) for published related articles without any time limit. The Cochrane handbook was used to determine the risk of bias of the included articles. The obtained data were analyzed in RevMan and reported in forest plots. The Odds Ratio (OR) was used to find the effect of the dichotomous data and the Mean Difference (MD) for the continuous data. The heterogeneity of the studies was assessed using I², T² and Chi². The random effect was used instead of fixed effect if I² >40%. A total of 28 titles and abstracts were extracted, 9 articles entered into the meta-analysis. The meta-analysis results showed significant differences between EPO and control groups in terms of bishop score (MD=1.32; 95% CI: 0.98 to 1.66), reducing caesarean section rate (OR= 0.61; 95% CI: 0.43 to 0.86), duration of first stage of labor (MD= -98.67; 95% CI: -140.98 to -56.38) and duration of second stage of labor (MD= -10.98; 95% CI: -21.86 to -0.09). There were no significant differences in terms of birth weight (MD= 100.97; 95% CI: -11.91 to 213.84) and the frequency of induction with oxytocin (OR= 0.53; 95% CI: 0.27 to 1.01). It seems evening primrose oil be effective for cervical ripening, reducing cesarean section rate and shortening the duration of labor. Due to the high heterogeneity of the studies, the researchers recommend further researches on the subject using a standard tool based on the CONSORT statement.

Keywords: bishop score; cervical ripening; evening primrose oil; labor induction; RCT; term pregnancy

Corresponding author: Mojgan Mirghafourvand, Associate Professor, Social Determinants of Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran, Phone: 00989143206121, E-mail: mirghafourvand@gmail.com

Research funding: None declared.
Author contributions: ShH, SMA, AV and MM (corresponding author) participated in the study designing. SHH and AV searched the literature and selected studies, extracted data, assessed quality and drafted the manuscript. SMA and MM (corresponding author) revised the draft and all authors read and approved the final version of the manuscript.
Competing interests: The authors declare that they have no competing interests.
Informed consent: Not applicable.
Ethical approval: Not applicable.

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Received: 2020-08-29

Accepted: 2021-07-05

Published Online: 2021-07-14

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Artikel in diesem Heft

https://doi.org/10.1515/jcim-2020-0314

Schlagwörter für diesen Artikel

bishop score; cervical ripening; evening primrose oil; labor induction; RCT; term pregnancy